Catherine E. Costello, PhD
William Fairfield Warren Distinguished Professor, Biochemistry
Biography
Catherine Costello came to Boston University in 1994. That year she established the Center for Biomedical Mass Spectrometry, which has become an internationally recognized research center. She holds her primary appointment in the MED Biochemistry Department, with secondary appointments in the Department of Physiology & Biophysics and the Department of Chemistry. Her research, which focuses on determining the structures and functions of biologically important polymers, has revolutionized an important area of biochemistry by providing insights into the structures of molecules responsible for human disease. She is the author or co-author of more than 300 scientific papers, serves on a number of editorial boards of major journals, and has received numerous awards and honors, including the 2010 Field and Franklin Award from the American Chemical Society, one of the highest honors in her field.
Other Positions
- Research Professor, Physiology & Biophysics, Boston University School of Medicine
- Director, Center for Biomedical Mass Spectrometry, Boston University School of Medicine
- Graduate Faculty (Primary Mentor of Grad Students), Boston University School of Medicine, Graduate Medical Sciences
Education
- Georgetown University, PhD
- Georgetown University, MS
- Emmanuel College, AB
Publications
- Published on 8/7/2019
Tsybin YO, Bondarenko PV, Artaev VB, Zubarev RA, Costello CE. The Russian Mass Spectrometry Interest Group at ASMS: Over 20 Years of Science and Water Polo. J Am Soc Mass Spectrom. 2019 Aug 07. PMID: 31392702.
Read at: PubMed - Published on 7/15/2019
Chandler KB, Leon DR, Kuang J, Meyer RD, Rahimi N, Costello CE. N-Glycosylation regulates ligand-dependent activation and signaling of vascular endothelial growth factor receptor 2 (VEGFR2). J Biol Chem. 2019 Aug 30; 294(35):13117-13130. PMID: 31308178.
Read at: PubMed - Published on 6/28/2019
Sorvillo N, Mizurini DM, Coxon C, Martinod K, Tilvawala R, Cherpokova D, Salinger AJ, Seward RJ, Staudinger C, Weerapana E, Shapiro NI, Costello CE, Thompson PR, Wagner DD. Plasma Peptidylarginine Deiminase IV Promotes VWF-Platelet String Formation and Accelerates Thrombosis After Vessel Injury. Circ Res. 2019 Aug 16; 125(5):507-519. PMID: 31248335.
Read at: PubMed - Published on 6/5/2019
Brown Chandler K, Costello CE, Rahimi N. Glycosylation in the Tumor Microenvironment: Implications for Tumor Angiogenesis and Metastasis. Cells. 2019 Jun 05; 8(6). PMID: 31195728.
Read at: PubMed - Published on 5/16/2019
Magistrado-Coxen P, Aqeel Y, Lopez A, Haserick JR, Urbanowicz BR, Costello CE, Samuelson J. The most abundant cyst wall proteins of Acanthamoeba castellanii are lectins that bind cellulose and localize to distinct structures in developing and mature cyst walls. PLoS Negl Trop Dis. 2019 May; 13(5):e0007352. PMID: 31095564.
Read at: PubMed - Published on 5/1/2019
Campbell MP, Abrahams JL, Rapp E, Struwe WB, Costello CE, Novotny M, Ranzinger R, York WS, Kolarich D, Rudd PM, Kettner C. The minimum information required for a glycomics experiment (MIRAGE) project: LC guidelines. Glycobiology. 2019 05 01; 29(5):349-354. PMID: 30778580.
Read at: PubMed - Published on 4/4/2019
McDonald AJ, Leon DR, Markham KA, Wu B, Heckendorf CF, Schilling K, Showalter HD, Andrews PC, McComb ME, Pushie MJ, Costello CE, Millhauser GL, Harris DA. Altered Domain Structure of the Prion Protein Caused by Cu2+ Binding and Functionally Relevant Mutations: Analysis by Cross-Linking, MS/MS, and NMR. Structure. 2019 Jun 04; 27(6):907-922.e5. PMID: 30956132.
Read at: PubMed - Published on 3/5/2019
Shao D, Yao C, Kim MH, Fry J, Cohen RA, Costello CE, Matsui R, Seta F, McComb ME, Bachschmid MM. Improved mass spectrometry-based activity assay reveals oxidative and metabolic stress as sirtuin-1 regulators. Redox Biol. 2019 04; 22:101150. PMID: 30877853.
Read at: PubMed - Published on 2/6/2019
Nguyen DN, Xu B, Stanfield RL, Bailey JK, Horiya S, Temme JS, Leon DR, LaBranche CC, Montefiori DC, Costello CE, Wilson IA, Krauss IJ. Oligomannose Glycopeptide Conjugates Elicit Antibodies Targeting the Glycan Core Rather than Its Extremities. ACS Cent Sci. 2019 Feb 27; 5(2):237-249. PMID: 30834312.
Read at: PubMed - Published on 1/31/2019
Wei J, Wu J, Tang Y, Ridgeway ME, Park MA, Costello CE, Zaia J, Lin C. Characterization and Quantification of Highly Sulfated Glycosaminoglycan Isomers by Gated-Trapped Ion Mobility Spectrometry Negative Electron Transfer Dissociation MS/MS. Anal Chem. 2019 Feb 19; 91(4):2994-3001. PMID: 30649866.
Read at: PubMed
View 432 more publications: View full profile at BUMC