Catherine E. Costello, PhD

William Fairfield Warren Distinguished Professor, Biochemistry

Catherine Costello
617.638.6490
670 Albany St Biosquare III

Biography

Catherine Costello came to Boston University in 1994. That year she established the Center for Biomedical Mass Spectrometry, which has become an internationally recognized research center. She holds her primary appointment in the MED Biochemistry Department, with secondary appointments in the Department of Physiology & Biophysics and the Department of Chemistry. Her research, which focuses on determining the structures and functions of biologically important polymers, has revolutionized an important area of biochemistry by providing insights into the structures of molecules responsible for human disease. She is the author or co-author of more than 300 scientific papers, serves on a number of editorial boards of major journals, and has received numerous awards and honors, including the 2010 Field and Franklin Award from the American Chemical Society, one of the highest honors in her field.

Other Positions

  • Research Professor, Physiology & Biophysics, Boston University School of Medicine
  • Director, Center for Biomedical Mass Spectrometry, Boston University School of Medicine
  • Graduate Faculty (Primary Mentor of Grad Students), Boston University School of Medicine, Graduate Medical Sciences

Education

  • Georgetown University, PhD
  • Georgetown University, MS
  • Emmanuel College, AB

Publications

  • Published on 3/28/2019

    McDonald AJ, Leon DR, Markham KA, Wu B, Heckendorf CF, Schilling K, Showalter HD, Andrews PC, McComb ME, Pushie MJ, Costello CE, Millhauser GL, Harris DA. Altered Domain Structure of the Prion Protein Caused by Cu2+ Binding and Functionally Relevant Mutations: Analysis by Cross-Linking, MS/MS, and NMR. Structure. 2019 Mar 28. PMID: 30956132.

    Read at: PubMed
  • Published on 3/5/2019

    Shao D, Yao C, Kim MH, Fry J, Cohen RA, Costello CE, Matsui R, Seta F, McComb ME, Bachschmid MM. Improved mass spectrometry-based activity assay reveals oxidative and metabolic stress as sirtuin-1 regulators. Redox Biol. 2019 Apr; 22:101150. PMID: 30877853.

    Read at: PubMed
  • Published on 2/19/2019

    Campbell MP, Abrahams JL, Rapp E, Struwe WB, Costello CE, Novotny M, Ranzinger R, York WS, Kolarich D, Rudd PM, Kettner C. The Minimum Information Required for a Glycomics Experiment (MIRAGE) Project: LC Guidelines. Glycobiology. 2019 Feb 19. PMID: 30778580.

    Read at: PubMed
  • Published on 2/6/2019

    Nguyen DN, Xu B, Stanfield RL, Bailey JK, Horiya S, Temme JS, Leon DR, LaBranche CC, Montefiori DC, Costello CE, Wilson IA, Krauss IJ. Oligomannose Glycopeptide Conjugates Elicit Antibodies Targeting the Glycan Core Rather than Its Extremities. ACS Cent Sci. 2019 Feb 27; 5(2):237-249. PMID: 30834312.

    Read at: PubMed
  • Published on 1/31/2019

    Wei J, Wu J, Tang Y, Ridgeway ME, Park MA, Costello CE, Zaia J, Lin C. Characterization and Quantification of Highly Sulfated Glycosaminoglycan Isomers by Gated-Trapped Ion Mobility Spectrometry Negative Electron Transfer Dissociation MS/MS. Anal Chem. 2019 Feb 19; 91(4):2994-3001. PMID: 30649866.

    Read at: PubMed
  • Published on 1/18/2019

    Chandler KB, Mehta N, Leon DR, Suscovich TJ, Alter G, Costello CE. Multi-isotype Glycoproteomic Characterization of Serum Antibody Heavy Chains Reveals Isotype- and Subclass-Specific N-Glycosylation Profiles. Mol Cell Proteomics. 2019 Apr; 18(4):686-703. PMID: 30659065.

    Read at: PubMed
  • Published on 12/11/2018

    Bandini G, Leon DR, Hoppe CM, Zhang Y, Agop-Nersesian C, Shears MJ, Mahal LK, Routier FH, Costello CE, Samuelson J. O-Fucosylation of thrombospondin-like repeats is required for processing of microneme protein 2 and for efficient host cell invasion by Toxoplasma gondii tachyzoites. J Biol Chem. 2019 Feb 08; 294(6):1967-1983. PMID: 30538131.

    Read at: PubMed
  • Published on 6/1/2018

    Ho RX, Meyer RD, Chandler KB, Ersoy E, Park M, Bondzie PA, Rahimi N, Xu H, Costello CE, Rahimi N. MINAR1 is a Notch2-binding protein that inhibits angiogenesis and breast cancer growth. J Mol Cell Biol. 2018 Jun 01; 10(3):195-204. PMID: 29329397.

    Read at: PubMed
  • Published on 5/1/2018

    Hoppe CM, Albuquerque-Wendt A, Bandini G, Leon DR, Shcherbakova A, Buettner FFR, Izquierdo L, Costello CE, Bakker H, Routier FH. Apicomplexan C-Mannosyltransferases Modify Thrombospondin Type I-containing Adhesins of the TRAP Family. Glycobiology. 2018 05 01; 28(5):333-343. PMID: 29432542.

    Read at: PubMed
  • Published on 4/16/2018

    Khatri K, Pu Y, Klein JA, Wei J, Costello CE, Lin C, Zaia J. Comparison of Collisional and Electron-Based Dissociation Modes for Middle-Down Analysis of Multiply Glycosylated Peptides. J Am Soc Mass Spectrom. 2018 Jun; 29(6):1075-1085. PMID: 29663256.

    Read at: PubMed

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