Catherine E. Costello, PhD
William Fairfield Warren Distinguished Professor
Biography
Catherine Costello came to Boston University in 1994. That year she established the Center for Biomedical Mass Spectrometry, which has become an internationally recognized research center. She holds her primary appointment in the MED Biochemistry Department, with secondary appointments in the Department of Physiology & Biophysics and the Department of Chemistry. Her research, which focuses on determining the structures and functions of biologically important polymers, has revolutionized an important area of biochemistry by providing insights into the structures of molecules responsible for human disease. She is the author or co-author of more than 300 scientific papers, serves on a number of editorial boards of major journals, and has received numerous awards and honors, including the 2010 Field and Franklin Award from the American Chemical Society, one of the highest honors in her field.
Other Positions
- Professor, Biochemistry & Cell Biology, Boston University Chobanian & Avedisian School of Medicine
- Research Professor, Pharmacology, Physiology & Biophysics, Boston University Chobanian & Avedisian School of Medicine
- Director, Center for Biomedical Mass Spectrometry, Boston University Chobanian & Avedisian School of Medicine
- Member, BU-BMC Cancer Center, Boston University
- Member, Amyloidosis Center, Boston University
- Member, Evans Center for Interdisciplinary Biomedical Research, Boston University
- Member, Genome Science Institute, Boston University
- Graduate Faculty (Primary Mentor of Grad Students), Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences
Education
- Georgetown University, PhD
- Georgetown University, MS
- Emmanuel College, AB
Publications
- Published on 1/30/2023
Sanes JT, Costello CE, Steere AC. Heightened Pro-inflammatory Glycosylation of Borrelia burgdorferi IgG Antibodies in Synovial Fluid in Patients with Antibiotic-Refractory Lyme Arthritis. Arthritis Rheumatol. 2023 Jan 30. PMID: 36716113.
Read at: PubMed - Published on 10/17/2022
Wel H, Garcia AM, Gas-Pascual E, Willis MM, Kim HW, Bandini G, Gaye MM, Costello CE, Samuelson J, West CM. Spindly is a nucleocytosolic O-fucosyltransferase in Dictyostelium and related proteins are widespread in protists and bacteria. Glycobiology. 2022 Oct 17. PMID: 36250576.
Read at: PubMed - Published on 6/10/2022
Zhu G, Yan W, Wang X, Cheng R, Naowarojna N, Wang K, Wang J, Song H, Wang Y, Liu H, Xia X, Costello CE, Liu X, Zhang L, Liu P. Dissecting the Mechanism of the Nonheme Iron Endoperoxidase FtmOx1 Using Substrate Analogues. JACS Au. 2022 Jul 25; 2(7):1686-1698. PMID: 35911443.
Read at: PubMed - Published on 2/17/2022
Gaye MM, Ward CM, Piasecki AJ, Stahl VL, Karagianni A, Costello CE, Ravid K. Characterization of Glycoproteoforms of Integrins a2 and ß1 in Megakaryocytes in the Occurrence of JAK2V617F Mutation-Induced Primary Myelofibrosis. Mol Cell Proteomics. 2022 Apr; 21(4):100213. PMID: 35182768.
Read at: PubMed - Published on 2/14/2022
Chen Z, Wei J, Tang Y, Lin C, Costello CE, Hong P. GlycoDeNovo2: An Improved MS/MS-Based De Novo Glycan Topology Reconstruction Algorithm. J Am Soc Mass Spectrom. 2022 Mar 02; 33(3):436-445. PMID: 35157458.
Read at: PubMed - Published on 2/8/2022
Amraei R, Xia C, Olejnik J, White MR, Napoleon MA, Lotfollahzadeh S, Hauser BM, Schmidt AG, Chitalia V, Mühlberger E, Costello CE, Rahimi N. Extracellular vimentin is an attachment factor that facilitates SARS-CoV-2 entry into human endothelial cells. Proc Natl Acad Sci U S A. 2022 02 08; 119(6). PMID: 35078919.
Read at: PubMed - Published on 10/22/2021
Pianta A, Chiumento G, Ramsden K, Wang Q, Strle K, Arvikar S, Costello CE, Steere AC. Identification of Novel, Immunogenic HLA-DR-Presented Prevotella copri Peptides in Patients With Rheumatoid Arthritis. Arthritis Rheumatol. 2021 12; 73(12):2200-2205. PMID: 34042327.
Read at: PubMed - Published on 10/17/2021
Liu L, Veis J, Reiter W, Motari E, Costello CE, Samuelson JC, Ammerer G, Levin DE. Regulation of Pkc1 Hyper-Phosphorylation by Genotoxic Stress. J Fungi (Basel). 2021 Oct 17; 7(10). PMID: 34682295.
Read at: PubMed - Published on 9/9/2021
Rahimi N, Ho RXY, Chandler KB, De La Cena KOC, Amraei R, Mitchel AJ, Engblom N, Costello CE. The cell adhesion molecule TMIGD1 binds to moesin and regulates tubulin acetylation and cell migration. J Biomed Sci. 2021 Sep 09; 28(1):61. PMID: 34503512.
Read at: PubMed - Published on 6/30/2021
Amraei R, Yin W, Napoleon MA, Suder EL, Berrigan J, Zhao Q, Olejnik J, Chandler KB, Xia C, Feldman J, Hauser BM, Caradonna TM, Schmidt AG, Gummuluru S, Mühlberger E, Chitalia V, Costello CE, Rahimi N. CD209L/L-SIGN and CD209/DC-SIGN Act as Receptors for SARS-CoV-2. ACS Cent Sci. 2021 Jul 28; 7(7):1156-1165. PMID: 34341769.
Read at: PubMed
View 454 more publications: View full profile at BUMC