Arjun Guha, PhD

Assistant Professor, Medicine

Arjun Guha
617.638.4860
72 E. Concord St Housman (R)

Biography

Research Interests: Cell fate specification and cellular plasticity in lung development and repair, Non-classical stem cell hierarchies, Pulmonary neuroepithelial cells and their microenvironment, and Notch signaling

Other Positions

  • Member, Evans Center for Interdisciplinary Biomedical Research, Boston University

Education

  • Manipal University, PhD
  • Wabash College, BS

Publications

  • Published on 3/23/2022

    Basu DS, Bhavsar R, Gulami I, Chavda S, Lingamallu SM, Muddashetty R, Veeranna C, Chattarji S, Thimmulappa R, Bhattacharya A, Guha A. FMRP protects the lung from xenobiotic stress by facilitating the Integrated Stress Response. J Cell Sci. 2022 Mar 23. PMID: 35319067.

    Read at: PubMed
  • Published on 10/8/2021

    Kizhedathu A, Chhajed P, Yeramala L, Sain Basu D, Mukherjee T, Vinothkumar KR, Guha A. Duox-generated reactive oxygen species activate ATR/Chk1 to induce G2 arrest in Drosophila tracheoblasts. Elife. 2021 10 08; 10. PMID: 34622778.

    Read at: PubMed
  • Published on 9/2/2020

    Kizhedathu A, Kunnappallil RS, Bagul AV, Verma P, Guha A. Multiple Wnts act synergistically to induce Chk1/Grapes expression and mediate G2 arrest in Drosophila tracheoblasts. Elife. 2020 09 02; 9. PMID: 32876044.

    Read at: PubMed
  • Published on 4/16/2018

    Kizhedathu A, Bagul AV, Guha A. Negative regulation of G2-M by ATR (mei-41)/Chk1(Grapes) facilitates tracheoblast growth and tracheal hypertrophy in Drosophila. Elife. 2018 04 16; 7. PMID: 29658881.

    Read at: PubMed
  • Published on 4/11/2017

    Guha A, Deshpande A, Jain A, Sebastiani P, Cardoso WV. Uroplakin 3a+ Cells Are a Distinctive Population of Epithelial Progenitors that Contribute to Airway Maintenance and Post-injury Repair. Cell Rep. 2017 Apr 11; 19(2):246-254. PMID: 28402849.

    Read at: PubMed
  • Published on 10/22/2015

    Rao PR, Lin L, Huang H, Guha A, Roy S, Kornberg TB. Developmental compartments in the larval trachea of Drosophila. Elife. 2015 Oct 22; 4. PMID: 26491942.

    Read at: PubMed
  • Published on 7/16/2015

    Cai Y, Yoneda M, Tomita T, Kurotani R, Okamoto M, Kido T, Abe H, Mitzner W, Guha A, Kimura S. Transgenically-expressed secretoglobin 3A2 accelerates resolution of bleomycin-induced pulmonary fibrosis in mice. BMC Pulm Med. 2015 Jul 16; 15:72. PMID: 26178733.

    Read at: PubMed
  • Published on 2/21/2014

    Guha A, Vasconcelos M, Zhao R, Gower AC, Rajagopal J, Cardoso WV. Analysis of Notch signaling-dependent gene expression in developing airways reveals diversity of Clara cells. PLoS One. 2014; 9(2):e88848. PMID: 24586412.

    Read at: PubMed
  • Published on 7/13/2012

    Guha A, Vasconcelos M, Cai Y, Yoneda M, Hinds A, Qian J, Li G, Dickel L, Johnson JE, Kimura S, Guo J, McMahon J, McMahon AP, Cardoso WV. Neuroepithelial body microenvironment is a niche for a distinct subset of Clara-like precursors in the developing airways. Proc Natl Acad Sci U S A. 2012 Jul 31; 109(31):12592-7. PMID: 22797898.

    Read at: PubMed
  • Published on 9/12/2009

    Guha A, Lin L, Kornberg TB. Regulation of Drosophila matrix metalloprotease Mmp2 is essential for wing imaginal disc:trachea association and air sac tubulogenesis. Dev Biol. 2009 Nov 15; 335(2):317-26. PMID: 19751719.

    Read at: PubMed

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