Andrew J. Henderson, PhD
Professor, Medicine
Biography
Research in my laboratory focuses on cellular mechanisms that regulate HIV replication and transcription. Current projects include exploring how signaling influences HIV infection and latency, devising strategies for long-term repression of HIV provirus and characterizing the transcriptional status of HIV provirus in T cell and macrophage subsets. In addition, we are interested in mechanisms that contribute to HIV associated inflammation. I have served on NIH study sections and special emphasis panels and was a member and chair for the NIH AIDS Molecular and Cellular Biology Study Section. In addition to my research, I have always been proactive in undergraduate and graduate training and I am the current co-Director of the BU PREP post-bac program. I also have organized and participated in programs for international students including a summer program with University of Dammam, Saudi Arabia, a short course at Makerere University in Uganda and a Fogarty International Center training grant with the University of Liberia.
Other Positions
- Assistant Dean, Oral Health Sciences, Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences
- Associate Professor, Virology, Immunology & Microbiology, Boston University Chobanian & Avedisian School of Medicine
- Member, BU-BMC Cancer Center, Boston University
- Member, Evans Center for Interdisciplinary Biomedical Research, Boston University
- Boston Medical Center
- Member, Genome Science Institute, Boston University
- Graduate Faculty (Primary Mentor of Grad Students) , Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences
- Co-Director, Integrated Pilot Grant Award Program, Clinical and Translational Science Institute, Boston University
Education
- University of California, Riverside, PhD
- University of California, Riverside, MS
- University of California, Riverside, BS
Publications
- Published on 5/9/2024
Kilroy JM, Leal AA, Henderson AJ. Chronic HIV Transcription, Translation, and Persistent Inflammation. Viruses. 2024 May 09; 16(5). PMID: 38793632.
Read at: PubMed - Published on 2/1/2023
Basukala B, Rossi S, Bendiks S, Gnatienko N, Patts G, Krupitsky E, Lioznov D, So-Armah K, Sagar M, Cheng C, Henderson AJ. Virally Suppressed People Living with HIV Who Use Opioids Have Diminished Latency Reversal. Viruses. 2023 Feb 01; 15(2). PMID: 36851631.
Read at: PubMed - Published on 6/28/2022
Kuniholm J, Coote C, Henderson AJ. Defective HIV-1 genomes and their potential impact on HIV pathogenesis. Retrovirology. 2022 Jun 28; 19(1):13. PMID: 35764966.
Read at: PubMed - Published on 1/12/2022
Dalecki AG, Greer BD, Duverger A, Strange EL, Carlin E, Wagner F, Shi B, Lowman KE, Perez M, Tidwell C, Kaczmarek Michaels K, Giattina S, Bossmann SH, Henderson AJ, Hu H, Kutsch O. Host T Cell Dedifferentiation Effects Drive HIV-1 Latency Stability. J Virol. 2022 03 09; 96(5):e0197421. PMID: 35019721.
Read at: PubMed - Published on 12/28/2021
Kuniholm J, Armstrong E, Bernabe B, Coote C, Berenson A, Patalano SD, Olson A, He X, Lin NH, Fuxman Bass JI, Henderson AJ. Intragenic proviral elements support transcription of defective HIV-1 proviruses. PLoS Pathog. 2021 12; 17(12):e1009982. PMID: 34962974.
Read at: PubMed - Published on 11/2/2021
Ragan EJ, McCallum C, Marathe J, Cole M, Hofman M, Henderson AJ, Flack T, Miller NS, Burks EJ, Zhao GQ, Denis R, Lin NH, Jacobson KR, Andry CD, Pelton SI, Duffy ER, Bhadelia N. Pandemic Response Requires Research Samples: A U.S. Safety-Net Hospital's Experience and Call for National Action. Ann Intern Med. 2021 12; 174(12):1727-1732. PMID: 34724402.
Read at: PubMed - Published on 3/16/2021
Pedro KD, Agosto LM, Sewell JA, Eberenz KA, He X, Fuxman Bass JI, Henderson AJ. A functional screen identifies transcriptional networks that regulate HIV-1 and HIV-2. Proc Natl Acad Sci U S A. 2021 03 16; 118(11). PMID: 33836568.
Read at: PubMed - Published on 12/2/2020
Santoso CS, Li Z, Lal S, Yuan S, Gan KA, Agosto LM, Liu X, Pro SC, Sewell JA, Henderson A, Atianand MK, Fuxman Bass JI. Comprehensive mapping of the human cytokine gene regulatory network. Nucleic Acids Res. 2020 12 02; 48(21):12055-12073. PMID: 33179750.
Read at: PubMed - Published on 10/12/2020
Olson A, Basukala B, Lee S, Gagne M, Wong WW, Henderson AJ. Targeted Chromatinization and Repression of HIV-1 Provirus Transcription with Repurposed CRISPR/Cas9. Viruses. 2020 10 12; 12(10). PMID: 33053801.
Read at: PubMed - Published on 10/1/2020
He X, Eddy JJ, Jacobson KR, Henderson AJ, Agosto LM. Enhanced Human Immunodeficiency Virus-1 Replication in CD4+ T Cells Derived From Individuals With Latent Mycobacterium tuberculosis Infection. J Infect Dis. 2020 10 01; 222(9):1550-1560. PMID: 32417884.
Read at: PubMed
View 63 more publications: View full profile at BUMC