Alexander Y. Walley, MD

Professor, Boston University Chobanian & Avedisian School of Medicine

Biography

Dr Walley is Professor of Medicine and an addiction expert at Boston Medical Center and Chobanian and Avedisian School of Medicine focused on the medical complications of substance use, specifically HIV and overdose. Dr Walley has conducted multiple studies related to the opioid crisis and the integration of addiction specialty care and general medical care. He led, as PI, a CDC-SAMHSA-Epi-AID investigation of the surge in fentanyl-related overdose, a CDC-funded study of the Massachusetts community naloxone program which demonstrated community-level reductions in overdose death rates, and a SAMHSA-funded program that integrated addiction treatment into the clinical care of people with/at risk for HIV. He is principal investigator for several CDC and NIH funded studies of community overdose interventions, including post-overdose outreach programs and overdose prevention hotlines. For the NIH-funded HEALing Communities Study - Massachusetts, he served as the Care Continuum Core Director 2019-2025. He has worked as Co-I with addiction, overdose, and HIV expertise on NIDA and NIAAA-funded clinical trials and cohort studies. He has led several studies of overdose and medication for opioid use disorder in the population individually-linked Massachusetts Public Health Data Warehouse that have demonstrated the epidemiology of overdose, its risk factors, along with the benefits of and gaps in medication for opioid use disorder.

Dr. Walley is a founding director of the Grayken Addiction Medicine Fellowship. From 2011 to 2022, 20 addiction specialists graduated, 6 of whom serve as directors for addiction medicine fellowships, 13 are faculty at medical schools, 9 at Boston University School of Medicine and Boston Medical Center. He was a founding board member and treasurer of the Addiction Medicine Fellowship Director’s Association 2016-2019 and American College of Academic Addiction Medicine (ACAAM) starting in 2019. He is currently the past president for ACAAM for 2026-2027. With his mentor, Dr. Jeffrey Samet, he is multi-PI on the NIDA-funded R25 Clinical Addiction Research and Education Program, which supports the Chief Resident and Fellow Immersion Training and the CARE Faculty Scholar programs and has been continuously funded since 2002. He is co-editor in chief of the Addiction Science and Clinical Practice peer-reviewed journal.

Dr. Walley provides primary care and addiction medicine consultations in the HIV primary care clinic at BMC. He founded BMC’s inpatient Addiction Consult Service in 2015 and the Faster Paths low-barrier access substance use bridge clinic in 2016. He previously was a site medical director for opioid treatment programs in Boston from 2007 to 2016. He serves as the medical director for the Massachusetts Department of Public Health’s Bureau of Substance Addiction Services, the Overdose Prevention Program, and the SafeSpot Overdose Prevention Hotline. Since 2007, the MDPH program, under his medical license and oversight has trained and equipped hundreds of thousands of people in Massachusetts’s communities with naloxone rescue kits, including people at-risk for overdose and their social networks. Since 2022, the SafeSpot has provided 24/7 access to trained, paid peer operators who have taken over 17,000 calls and facilitated the successful rescue of over 50 callers.

Publications

  • Published 4/20/2026

    Reed GE, McMahan VM, Chang YG, Johnson NL, Walley AY, Coffin PO, Harris MTH. A comparison of opioid overdose risk behaviors by race and ethnicity among overdose survivors in Boston, MA, and San Francisco, CA. Harm Reduct J. 2026 Apr 20. PMID: 42010666.

    Read at: PubMed

  • Published 4/20/2026

    Xuan Z, Walley AY, Formica SW, Wang J, Gamble MC, Kosakowski S, Murray S, Wiggins M, Cogan AG, Haley DF, Hyde J, Bagley SM. Impact of a stimulant-inclusive post-overdose outreach toolkit on engagement of overdose survivors who use stimulants: An interrupted time series analysis. Drug Alcohol Depend. 2026 Jun 01; 283:113129. PMID: 42014260.

    Read at: PubMed

  • Published 4/19/2026

    Lewis O, Srinivasan S, Bayly R, Cordes J, Shrestha S, O'Reilly MR, Kimmel SD, Walley AY, Babakhanlou-Chase H, Stopka TJ. Corrigendum to "Filling in the gaps: A geospatial approach to optimizing placement of methadone clinics in Massachusetts" [Journal of Substance Use and Addiction Treatment, 181 (2026) 209848]. J Subst Use Addict Treat. 2026 Aug; 187:209969. PMID: 42002453.

    Read at: PubMed

  • Published 4/18/2026

    Weinstein ZM, Jadovich E, Drainoni ML, LaRochelle M, Yan S, Lee J, Bettano A, Beers D, Walley AY, Samet JH. Implementation of addiction consult services and bridge clinics in the HEALing communities study in Massachusetts. Drug Alcohol Depend. 2026 Jul 01; 284:113165. PMID: 42033894.

    Read at: PubMed

  • Published 4/1/2026

    Epstein RL, Munroe S, Erdman EA, Bettano A, Curtis MR, White L, Wachman EM, Osinski A, Walley AY, Linas BP. Hepatitis C Virus Testing in Perinatally Exposed Children. JAMA Netw Open. 2026 Apr 01; 9(4):e260743. PMID: 41996118.

    Read at: PubMed

Other Positions

  • Member, Evans Center for Interdisciplinary Biomedical Research
    Boston University
  • Faculty, Medicine
    Boston University Chobanian & Avedisian School of Medicine
  • Courtesy Staff Privileges, Medicine
    Boston Medical Center

Education

  • Johns Hopkins University School of Medicine, MD
  • Boston University School of Public Health, MSc
  • Harvard College, AB