PhD, Boston University School of Medicine
General field of research:
Affiliations other than medicine:
Evans Center for Interdisciplinary Biomedical Research
Department of Medicine, Hematology Oncology Section, Boston University School of Medicine, Boston Medical Center
Rm. 437A, EBRC, 650 Albany St., Boston, MA 02118
Phone: (617)-638 7028
Rm. 430, EBRC, 650 Albany St., Boston, MA 02118
Phone: (617)-638 7535/7029
Fax: (617)-638 7140
Other research websites:
Research group information
Chunyan Bai, Research Assistant, ChuYan.Bai@bmc.org
John P. Lovell, Summer student, email@example.com
Lynsie Ranker, Summer student, firstname.lastname@example.org
Do Quyen T. Pham, IHC Core Lab Technical Assistant, email@example.com
B1 B cell; Regulatory T cells; Regulatory B cells; inflammation; Autoimmune diseases; Cardiovascular diseases
Summary of research interest:
Our lab is interested in studying B cells mediated immune regulation in autoimmune diseases and cardiovascular diseases. We are particularly interested in a sub-population of B lymphocytes called B1 B cells. Our preliminary study revealed many faces of B1 B cells in health and diseases. On one hand B1 B cells are critical for immune defense and immune regulation through interaction with other immune cells and producing natural antibodies. On the other hand, B1 B cells are potential “troublemakers” in autoimmune diseases because of their auto-reactivity. A better understanding of the balance between the immune-regulation and pathogenicity of B1 B cells are of significant importance in studying inflammatory autoimmune diseases and cardiovascular diseases.
Zhong, X., T. J. Schneider, et al. (2001). An alternatively spliced long form of Fas apoptosis inhibitory molecule (FAIM) with tissue-specific expression in the brain. Mol Immunol 38: 65-72.
Zhong, X.,, T. Mizuno, and T. L. Rothstein. (2003). Fas-induced apoptosis in B cells. Apoptosis 8:451.
Zhong, X., C. Bai, W. Gao, T. B. Strom, and T. L. Rothstein. (2004). Featured Article of the Month: Suppression of expression and function of negative immune regulator PD-1 by certain pattern recognition and cytokine receptor signals associated with immune system danger. Int Immunol 16:1181.
Barrington, R. A., X. Zhong, M. Zhang, H. Jonsson, N. Holodick, A. Cherukuri, S. K. Pierce, T. L. Rothstein, and M. C. Carroll. (2005). CD21/CD19 coreceptor signaling promotes B cell survival during primary immune responses. J Immunol 175:2859.
Zhong, X., J. R. Tumang, W. Gao, C. Bai, and T. L. Rothstein. (2007). PD-L2 expression extends beyond dendritic cells/macrophages to B1 cells enriched for V(H)11/V(H)12 and phosphatidylcholine binding. Eur J Immunol 37:2405-2410.
Zhong, X., W. Gao, N. Degauque, C. Bai, Y. Lu, J. Kenny, M. Oukka, T. B. Strom, and T. L. Rothstein. (2007). Reciprocal generation of Th1/Th17 and T(reg) cells by B1 and B2 B cells. Eur J Immunol 37:2400-2404.
Repetny, K., X. Zhong, N. Holodick, T. Rothstein, U. Hansen. (2009). Binding of LBP-1a to specific immunoglobulin switch regions in vivo correlates with specific repression of class switch recombination. Eur J Immunol 39(5):1387-94
Ding, H., L. Wang, X. Wu, J. Yan, Y. He, B. Ni, W. Gao, X. Zhong. (2009). Blockade of B Cell-Activating Factor Suppresses Lupus-like Syndrome in Autoimmune BXSB Mice. J Cell Mol Med (in press).
Technologies available for sharing upon request:
Flow Cytometry; Lymphocytes isolation, activation,cell proliferation assay; ELISA; ANA; IHC; Animal model analysis; Retroviral transfection; Bone Marrow Adoptive Transfer