Frederick L. Ruberg

Associate Professor of Medicine and Radiology


MD, University of Pennsylvania School of Medicine

General field of research:

Cardiac Imaging

Affiliations other than medicine:

Whitaker CVI

Contact information:

Collamore 712D

Phone: (617)-638 8968

Fax: (617)-638 8969


Cardiovascular Magnetic Resonance Imaging; Cardiac Computed Tomography; Amyloidosis; Echocardiography; Magnetic Resonance Spectroscopy; Obesity

Summary of research interest:

Dr. Ruberg is an Associate Professor of Medicine and Radiology at Boston University School of Medicine and the Director of the Advanced Cardiac Imaging Program at Boston Medical Center. His clinical and research expertise is in the field of cardiac imaging with advanced training in echocardiography, cardiovascular magnetic resonance imaging (MRI), and cardiac computed tomography (CT). He is a member of the Cardiac Imaging Committee of the scientific Council on Clinical Cardiology of the American Heart Association. Dr. Ruberg is a peer reviewer for numerous journals relevant to cardiovascular medicine including Circulation, Journal of the American College of Cardiology, Nature Clinical Practice Cardiovascular Medicine, Journal of Cardiovascular Magnetic Resonance, and Obesity.  In addition he is a member of the editorial board of Circulation: Cardiovascular Imaging. Dr. Ruberg is also the Co-Director of the Cardiovascular Fellowship Training Program.

Dr. Ruberg’s research interest is in the application of MRI-based techniques, including MR spectroscopy, to quantify lipid (fat) deposition within the heart and vasculature as it relates to cardiac and vascular dysfunction.  He also has a strong interest in amyloid cardiomyopathy, and the utility of cardiac MR in the diagnosis and management of this disease. He is a co-investigator on numerous extramurally funded projects with collaborations involving investigators in cardiovascular medicine, biophysics, geriatrics, cardiac surgery, and hematology/oncology.

Recent publications:

1. Ruberg FL, Judge DP, Maurer MS.  2009.  Familial amyloid cardiomyopathy due to TTR mutations: an underappreciated cause of restrictive cardiomyopathy. J Card Fail.;15(5):464. PubMed PMID: 19477408.

2. Ruberg FL, Appelbaum E, Davidoff R, Ozonoff A, Kissinger KV, Harrigan C, Skinner M, Manning WJ. 2009.  Diagnostic and prognostic utility of cardiovascular magnetic resonance imaging in light-chain cardiac amyloidosis. Am J Cardiol.;103(4):544-9. PubMed PMID: 19195518; PubMed Central PMCID: PMC2680134.

3. Dinwoodey DL, Skinner M, Maron MS, Davidoff R, Ruberg FL. 2008.  Light-chain amyloidosis with echocardiographic features of hypertrophic cardiomyopathy. Am J Cardiol.;101(5):674-6. Epub 2007 Dec 21. PubMed PMID: 18308019.

4. Rosito GA, Massaro JM, Hoffmann U, Ruberg FL, Mahabadi AA, Vasan RS, O’Donnell CJ, Fox CS. 2008.  Pericardial fat, visceral abdominal fat, cardiovascular disease risk factors, and vascular calcification in a community-based sample: the Framingham Heart Study. Circulation;117(5):605-13.  PubMed PMID: 18212276.

5. Ruberg FL.  2007.  Myocardial lipid accumulation in the diabetic heart. Circulation;116(10):1110-2. Review. PubMed PMID: 17768302.

6. Qiao Y, Ronen I, Viereck J, Ruberg FL, Hamilton JA. 2007.  Identification of atherosclerotic lipid deposits by diffusion-weighted imaging. Arterioscler Thromb Vasc Biol.; (6):1440-6. Erratum in: Arterioscler Thromb Vasc Biol. 2008 Feb;28(2):e10. PubMed PMID: 17379838.

7. Ruberg FL, Viereck J, Phinikaridou A, Qiao Y, Loscalzo J, Hamilton JA.  2006.  Identification of cholesteryl esters in human carotid atherosclerosis by ex vivo image-guided proton MRS. J Lipid Res.;47(2):310-7.  PubMed PMID: 16317172.

8. Ruberg FL, McDonnell ME, Trabb J, Shemin RJ, Hoyt RF Jr, Braverman LE, Balady GJ. 2006.  An intracardiac accessory thyroid gland. Am J Cardiol.; 97(6):926-8. PubMed PMID: 16516604.