GSI Faculty Members

Albrecht, Kenn
Primary Affiliation: Medicine, Biomedical Genetics
Research Focus: developmental genetics and genomics, mouse genetics, linkage analysis, gene discovery and characterization
Area of Interest: organogenesis, mouse models of human disease, the relationship between development and cancer, ovarian cancer, stem cells,
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Alekseyev, Yuriy
Primary Affiliation: Microarray Core
Research Focus: Director, Microarray Resource Center
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Amar, Salomon
Primary Affiliation: Dental Medicine, Perio/Oral Biology
Research Focus: Innate immunity
Area of Interest: mouse model for obesity atherosclerosis, crohn’s and RA
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Applebaum, Kate
Primary Affiliation: Public Health, Epidemiology
Research Focus: genetic epidemiology, gene-environment interaction, genome-wide association analysis
Area of Interest: cancer, diabetes, environmental and occupational exposures, endotoxin, biomarkers, immunology
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Benjamin, Emelia J
Primary Affiliation: Medicine, Cardiology/Framingham Heart Study
Research Focus: genetic epidemiology, genome-wide association analysis
Area of Interest: atrial fibrillation, inflammation
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Blusztajn, Jan Krzysztof
Primary Affiliation: Pathology, Laboratory Medicine
Research Focus: Neuroscience
Area of Interest: Epigenetic regulation of neuronal development and aging
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Bonegio, Ramon
Primary Affiliation: Medicine/Renal
Research Focus: Developmental genetics and genomics, Disease susceptibility
Area of Interest: Glomerulonephritis, Kidney development, Epithelial cell differentiation, Cell fate control
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Campion, MaryAnn Whalen
Primary Affiliation: Medicine, Genetic Counseling Program
Research Focus:
Area of Interest: genetic counseling, ethics in genetics, prenatal genetics, teratology
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Chen, Jiang-Fan

Primary Affiliation: Medicine, Neurology
Research Focus: molecular neuropharmacology, transcriptional regulation
Area of Interest: Adenosine receptor neurobiology, Parkinson’s disease, Huntington’s disease, Psychostimulant addiction, transcritional regulation
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Cohen, Herbert T
Primary Affiliation: Medicine, Medicine/Renal Section
Research Focus: cancer biology and genetics, molecular cell biology and genetics of renal epithelium, mouse genetics
Area of Interest: Renal cancer, polycystic kidney disease, kidney development
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Connor, John H.
Primary Affiliation: Medicine/Microbiology
Research Focus: viruses
Area of Interest: virus-host interaction
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Cotton, Robin W
Primary Affiliation: GMS, Biomedical Forensic Sciences, Anatomy and Neurobiology
Research Focus: Methods development/improvement for forensic DNA applications
Area of Interest: Application of STR and other genetic markers to analysis of forensic samples
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Cozier, Yvette
Primary Affiliation: Public Health, Slone Epidemiology Center
Research Focus: candidate genes, statistical genetics, gwas
Area of Interest: hypertension, sarcoidosis, cancer
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Dasgupta, Shoumita

Primary Affiliation: Medicine, Medicine/Biomedical Genetics
Research Focus: Graduate and Medical Education
Area of Interest: Teaching methods, diversity initiatives
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Demissie, Serkalem
Primary Affiliation: Public Health, Biostatistics
Research Focus: Statistical genetics, epidemiology, multivariate and interaction analyses, genome-wide association study; population stratification
Area of Interest: Plasma lipids, bone mineral density and bone geometry, biological aging
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Denis, Gerald V
Primary Affiliation: Medicine, Cancer Research Center
Research Focus: mouse models of lymphoma and leukemia, transcription, cell cycle, anti-cancer agents
Area of Interest: cancer genetics, genomic instability, tumor suppressors, hematopoietic malignancy
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DeStefano, Anita L
Primary Affiliation: Public Health, Biostatistics
Research Focus: statistical genetics, linkage analysis, genome-wide association analysis
Area of Interest: Neurological traits, Parkinson disease, Stroke, Dementia
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Dominguez, M. Isabel
Primary Affiliation: Medicine, Medicine/Hem-Onc
Research Focus: mechanism of signal transduction in embryonic development and tumorigenesis
Area of Interest: Wnt signaling, Xenopus dorsal axis formation, use of Xenopus bioassays to the study of human diseases, mouse cardiogenesis, progenitor cells, colon and breast cancer.
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Dupuis, Josée
Primary Affiliation: Public Health, Biostatistics
Research Focus: statistical genetics, robust and flexible statistical method development for linkage and genome-wide association analysis
Area of Interest: Statistical methodological development, type-2 diabetes, biomarker of inflammation
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Farrer, Lindsay A
Primary Affiliation: Medicine, Medicine/Biomedical Genetics
Research Focus: genetic epidemiology, gene discovery, complex disease genetics
Area of Interest: Alzheimer disease and dementia, hemoglobinopathies, substance dependence, macular degeneration, exceptional longevity, adult diseases
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Flynn, Maureen
Primary Affiliation: Medicine, Human Genetics
Research Focus: hereditary cancer syndromes, disparities in health
Area of Interest: genetic counseling, public health, hereditary cancer syndromes, clinical pediatric genetics
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Genco, Caroline Attardo
Primary Affiliation: Department of Medicine
Research Focus: Research in Dr. Genco’s laboratory spans basic, translational, and global health.  Areas of focus include the effects of chronic infections on systemic health, sexually transmitted infections, and respiratory infectious diseases. Her translational work has encompassed clinical studies evaluating immunological responses following acute inflammatory diseases in both a US chort and patients in Nanjing, China. Recent studies are utilizing RNA seq analysis to define both host and bacterial gene expression profiles during natural infection.
Area of Interest: Microbial gene regulation, microbiome, and gene expression profiling in human and mouse tissues
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Ghosh, Sajal
Primary Affiliation: Medicine, Cancer Research Center
Research Focus: Study of the role of non-coding viral RNA from leukemia viruses and Epstein Barr Virus in tumor development
Area of Interest: Viral Oncology, Cancer Biology, Anticancer Therapeutics
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Goldstein, Richard
Primary Affiliation: Medicine, Pediatric Infectious Diseases
Research Focus: Bacterial Pathogens: (i) evolution, phylogeny and population structure; (ii) genomics; (iii) in vivo expression, and (iv) vaccine development
Area of Interest: Areas of Interest: Streptococcus pneumoniae, Haemophilus influenzae, CF-associated Pseudomonas aeruginosa and Burkholderia cepacia, enteropathogenic Escherichia coli
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Hasturk, Hatice
Primary Affiliation: Dental Medicine, Periodontology and Oral Biology
Research Focus: Clinical research on periodontal diseases and resolution of inflammation
Area of Interest: Resolution of inflammation, relationship between periodontal inflammation and systemic diseases, novel therapeutic applications, animal models of periodontal inflammation and tissue regeneration
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Helmerhorst, Eva J
Primary Affiliation: Dental Medicine, Periodontology and Oral Biology
Research Focus: Oral fluid proteomics, enzymology, and microbiology
Area of Interest: Mass-spectrometric characterization of the post-translational processing of salivary proteins, antifungal activities
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Johnson, W. Evan
Primary Affiliation: Medicine, Computational Biomedicine
Research focus: Computational and statistical methods in personalized medicine
Area of Interest: Translational medicine, epigenomics, gene expression and regulation, cancer, ADHD, autism, rapid diagnostics
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Jun, Gyungah
Primary Affiliation: Medicine (Biomedical Genetics), Ophthalmology, Biostatitics
Research Focus: shared genetic risk factors for age-related diseases (bivariate and multivariate analysis), genome-wide linkage, genome-wide association, mutation detection, candidate gene study, database development and management
Area of Interest: Alzheimer’s disease, age-related cataract, age-related macular degeneration, diabetic nephropathy, idiopathic membranous nephropathy, breast cancer
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Kantarci, Alpdogan
Primary Affiliation: Dental Medicine, Periodontology and Oral Biology
Research Focus: inflammation, neutrophil biology
Area of Interest: Periodontal disease, diabetes, fibrosis
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Kramnik, Igor
Primary Affiliation: Medicine, Medicine/ Microbiology
Research Focus: mechanisms of innate host resistance and susceptibility to tuberculosis
Area of Interest: genetic and epigenetic control of macrophage differentiation and function,  novel methodologies for the analysis of host – pathogen interactions
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Lafyatis, Robert
Primary Affiliation: Medicine, Medicine/ Rheumatology
Research Focus: gene expression in autoimmune diseases: systemic sclerosis and systemic lupus erythematosus
Area of Interest: translational studies in systemic sclerosis, including studies of dermal and blood mononuclear cell gene epression, fibrosis, cytokines and murine models
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Lenburg, Marc
Primary Affiliation: Medicine, Pathology
Research Focus: transcriptome analysis, gene-expression biomarker discovery, data mining, management of large-scale data sets
Area of Interest: host response to tobacco exposure and other environmental toxins, cancer
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Liu, Ching-Ti
Primary Affiliation: Public Health, Biostatistics
Research Focus: statistical genetics and genomics
Area of Interest: Type 2 Diabetes, musculoskeletal traits and aging
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Liu, Pinghua
Primary Affiliation: CAS, Chemistry
Research Focus: epigenetics, natural product especially plant natural product biosynthetic gene identification and natural product production by bioengineering
Area of Interest: chemical basis of biological clock; cancer and infectious disease vaccine; metabolomics
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Lu, Weining
Primary Affiliation: Medicine, Renal/Medicine
Research Focus: human and mouse molecular genetics, kidney development, congenital anomalies of the kidney and urinary tract
Area of Interest: human gene mutations, mouse models of human disease, nephrogenesis, CAKUT, vesicoureteral reflux (VUR), chromosome abnormalities, polycystic kidney disease (PKD)
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Luo, Zhijun
Primary Affiliation: Medicine, Biochemistry
Research Focus: Protein phosphorylation and signal transduction
Area of Interest: Oncogenesis, energy metabolism
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Mahalingam, Meera
Primary Affiliation: Medicine, Dermatology
Research Focus: genomics of melanoma and atypical nevomelanocytic proliferations
Area of Interest: melanoma, atypical nevi
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McCall, Kim
Primary Affiliation: Biology
Research Focus: understanding molecular mechanisms of programmed cell death and its role in development
Area of Interest: Drosophila developmental biology, cell death, oogenesis
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Merkel, Peter
Primary Affiliation: Medicine, Medicine/Rheumatology/Clinicial Epidemiology
Research Focus: Genetic biomarkers, translational research, clinical epidemiology
Area of Interest: Vasculitis; Scleroderma
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Miller, Mark
Primary Affiliation: Medicine, Psychiatry
Research Focus: psychiatric genetics
Area of Interest: PTSD and related disorders
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Monach, Paul
Primary Affiliation: Medicine, Medicine/Rheumatology
Research Focus: association studies, candidate gene approaches
Area of Interest: Vasculitis, autoimmune diseases
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Montano, Monty
Primary Affiliation: Medicine, Medicine
Research Focus: muscle stem cell biology, host-pathogen genomics, aging science
Area of Interest: regenerative medicine, stem cell biology, muscle wasting, infectious disease pathology
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Mostoslavsky, Gustavo
Primary Affiliation: Medicine, Medicine/GI
Research Focus: stem cell biology, reprogramming, gene transfer
Area of Interest:
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Murabito, Joanne
Primary Affiliation: Medicine, Medicine/Framingham Study
Research Focus: genetic epidemiology, genome-wide association analysis
Area of Interest: Aging and age-related phenotypes, menopause, peripheral artery disease, cancer, depressive symptoms
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Myers, Richard H
Primary Affiliation: Medicine, Neurology
Research Focus: genetic epidemiology, gene discovery and characterization
Area of Interest: Mid and late life onset diseases, Huntington’s disease, Parkinson’s disease, cardiovascular disease
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Navarro, Caryn
Primary Affiliation: Medicine, Medicine/Biomedical Genetics
Research Focus: developmental genetics, drosophila genetics, cell biology, gene discovery and characterization, protein interactions
Area of Interest: cell fate specification, cell polarity, microtubule motor transport, RNA/protein localization, models for cancer and neurological disorder
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Nikolajczyk, Barbara
Primary Affiliation: Medicine, Microbiology
Research Focus: immune system in inflammatory disease; gene regulation
Area of Interest: transcription, signal transduction, inflammatory bowel disease, type 2 diabetes, periodontal disease
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O’Connor, George T.
Primary Affiliation: Medicine, Medicine/Pulmonary
Research Focus: COPD; asthma; sleep apnea; chronic lung disease; genetic epidemiology
Area of Interest:
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Oppenheim Frank G
Primary Affiliation: Dental Medicine, Periodontology & Oral Biology
Research Focus: salivary genetic polymorphisms
Area of Interest: Cariology, Peridontal Disease, Host defense mechanisms, Biofilm formation
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Pelton, Stephen I
Primary Affiliation: Medicine, Pediatric Infectious Diseases
Research Focus: bacterial recombination, virulence genes for Streptococcus pneumoniae and Haemophilus influenzae,
Area of Interest: Pneumococcal infection, Otitis Media, Vaccine Preventable Illness
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Perls, Thomas
Primary Affiliation: Medicine, Geriatrics
Research Focus: genetic epidmiology, gene discovery
Area of Interest: Aging, Extreme Longevity
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Perrine, Susan
Primary Affiliation: Cancer Center, Pediatric Hematology, Pharmacology and Experimental Therapeutics
Research Focus: Globin gene regulation, therapeutic gene regulation in hematology and oncology
Area of Interest: hemoglobin disorders, thalassemias, sickle cell disease, viral malignancies
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Ramirez, Maria I
Primary Affiliation: Medicine, Pulmonary
Research Focus: Lung development, epithelial cell differentiation
Area of Interest: Gene regulation, epigenetics
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Ravid, Katya
Primary Affiliation: Medicine, Biochemistry/Medicine
Research Focus: bone marrow stem cell development into the platelet lineage; adenosine receptor role in platelet and vascular function
Area of Interest: Mouse models for vascular disease; cell cycle control; transcriptional regulation of lineage specificaiton
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Remick, Daniel G
Primary Affiliation: Medicine, Pathology & Laboratory Medicine
Research Focus: Sepsis, inflammation, cytokines and asthma
Area of Interest: Sepsis, inflammation, cytokines and asthma
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Roche, Patricia (Winnie)
Primary Affiliation: Public Health, Health law
Research Focus: law, ethics and policy
Area of Interest: DNA/data banking for research; direct-to-consumer testing services; patient rights;
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Romney, Carla
Primary Affiliation: Medicine, Biochemistry/GMS
Research Focus: education initiatives
Area of Interest:
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Ruiz-Opazo, Nelson
Primary Affiliation: Medicine, Medicine/Molecular Medicine
Research Focus: genetics, gene polymorphisms, functional characterization, biological modeling (transgenesis)
Area of Interest: Cardiovascular diseases, learning and memory, vascular dementia, Alzheimer’s disease, gender-specific genetic determinants
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Sahin-Toth, Miklos
Primary Affiliation: Dental Medicine, Molecular and Cell Biology
Research Focus: biochemical mechanisms of genetic risk, gene discovery and characterization
Area of Interest: chronic pancreatitis
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Samuelson, John C
Primary Affiliation: Dental Medicine, Molecular and Cell Biology
Research Focus: parasitology, biochemistry, cell biology, and glycomics
Area of Interest: Entamoeba, Giardia, Trichomonas, Plasmodium, and Toxoplasma
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Sarkar, Sibaji
Primary Affiliation: Medicine, Cancer Research Center
Research Focus: Epigenetics, signal transduction,apoptosis
Area of Interest: Gene silencing, Regulation of epigenetics and signal transduction in cancer cells and platelets
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Schreiber, Barbara
Primary Affiliation: Medicine, Biochemistry
Research Focus: inflammation in atherosclerosis, role of serum amyloid A on smooth muscle cell function
Area of Interest: inflammation in atherosclerosis, smooth muscle cells, extracellular matrix, lipid metabolism
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Sebastiani, Paola
Primary Affiliation: Public Health, Biostatistics
Research Focus: statistical genetics and genomics, genome-wide association analysis, risk prediction modeling, networks
Area of Interest: aging and longevity, sickle cell anemia
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Segre, Daniel
Primary Affiliation: CAS, Bioinformatics
Research Focus: systems biology, computational genomics, evolutionary dynamics
Area of Interest: Metabolic and genetic interaction networks, microbial metabolism and regulation
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Seldin, David
Primary Affiliation: Medicine, Hematology-Oncology/Amyloid Treatment & Research Program
Research Focus: cancer genetics, genetics of systemic amyloidosis
Area of Interest:
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Seshardi, Sudha
Primary Affiliation: Medicine, Neurology
Research Focus: genetic epidemiology, Framingham Heart Study, risk factors and risk prediction
Area of Interest: Dementia, Alzheimer’s disease, Stroke, Structural and Functional Brain Aging
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Siggers, Trevor
Primary Affiliation: Biology
Research Focus: genomics and gene regulation in the immune and inflammatory systems
Area of Interest: transcription factor NF-kB
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Spanjaard, Remco
Primary Affiliation: Otolaryngology
Research Focus: Basic and translational cancer research
Area of Interest: nuclear receptor signaling, drug and biomarker discovery, nanotechnology-based diagnostics and drug delivery
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Stearns-Kurosawa, Deborah
Primary Affiliation: Medicine, Pathology & Lab Medicine
Research Focus: translational medicine, animal models of disease
Area of Interest: inflammation, sepsis, coagulation, cardiovascular disease, obesity, nonhuman primate & mouse models
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Steffen, Martin
Primary Affiliation: Medicine, Pathology and Laboratory Medicine
Research Focus: proteomics, computational biology
Area of Interest: early detection of cancer, pathogenesis of stroke
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Steinberg, Martin
Primary Affiliation: Medicine, Pediatrics, Pathology
Research Focus Sickle cell disease, inherited disorders of the erythrocyte
Area of Interest:
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Thiagalingam, Sam
Primary Affiliation: Medicine, Medicine/Biomedical Genetics
Research Focus: Cancer genetics and epigenomics, Cancer Metastasis, MMMN cancer progression model and Epigenetics
Area of Interest: Discovery of biomarkers for diagnosis & prognosis as well as for targeting for therapy of cancer. The role of Smad signaling pathway in disease progression. Epigenetic regulation of schizophrenia & bipolar disorder.
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Van Dyke, Thomas
Primary Affiliation: Dental Medicine, Oral Biology
Research Focus: regulation of inflammation
Area of Interest: models of human inflammatory disease (mouse, rabbit, minipig), Periodontal Disease, Diabetes, Cardiovascular Disease
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Wang, Catharine
Primary Affiliation: Community Health Sciences
Research Focus: genetic risk communication, genetic literacy, family history assessment, clinical utility
Area of Interest: public health genomics, cancer prevention and control,  interactive multimedia/ehealth, intervention development
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Waxman, David J
Primary Affiliation: CAS, Biology
Research Focus: genomic approaches to gene regulation
Area of Interest: growth hormone action, sexual dimorphsim of gene expression, genomic impact of endocrine disruptor chemicals, tumor systems-wide impact of chemotherapeutic and anti-angiogenic drugs
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Wise, Lauren A
Primary Affiliation: Public Health, Epidemiology
Research Focus: genetic epidemiology
Area of Interest: Reproductive outcomes (uterine fibroids)
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Wachman, Elisha M
Primary Affiliation: Medicine, Pediatrics
Research Focus: genetic epidemiology
Area of Interest: Neonatal Opioid withdrawal

Wolozin, Benjamin
Primary Affiliation: Medicine, Pharmacology
Research Focus: Pathophysiology of Neurodegeneration, cell biology, C. elegans
Area of Interest: Parkinson’s disease, Alzheimer’s disease, ALS
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Yang, Shi
Primary Affiliation: Medicine, Pathology and Lab Medicine
Research Focus: Colorectal Cancer, Breast Cancer, Epigenetics, Molecular Pathology
Area of Interest: Serrated Polyp Neoplasia Pathway in CRC. Breast Carcinogenesis in Animal model.
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Yu, Jun
Primary Affiliation: Department of Biochemistry, School of Medicine
Research Focus: Pulmonary arterial hypertension
Area of Interest: PDGF, VEGF and endothelin signal transduction in pulmonary vascular smooth muscle cells
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Zannis, Vassilis I
Primary Affiliation: Medicine, Medicine
Research Focus: molecular genetics
Area of Interest: Molecular genetics of apolipoproteins and lipoproteins in relation to atherosclerosis and Alzheimer’s disease
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Zou, Ying S
Primary Affiliation: Medicine, Center for Human Genetics
Research Focus: telomere and telomerase
Area of Interest: Aging and Cancer
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