Assen G. Marintchev, PhD

Associate Professor, Physiology & Biophysics

Assen Marintchev
617.358.8486
700 Albany Street, W336

Biography

Assen Marintchev, PhD, Physiology & Biophysics, is a scientist whose long-standing objective has been to provide a detailed structural and dynamic picture of the protein translation initiation in human cells, and its regulation. These interactions and the mechanisms they entail underlie pathological processes disrupting the integrated stress response, which, in turn, leads to a wide range of diseases, and neurodegenerative disorders in particular. His current research builds on his prior training to study the structure and dynamics of translation initiation complexes and involves his extensive training in NMR methodology and state-of-the-art understanding of biophysical chemistry.

Other Positions

  • Graduate Faculty (Primary Mentor of Grad Students), Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences

Education

  • University of Connecticut, PhD
  • Sofia University, MS
  • Sofia University, BS

Publications

  • Published on 6/10/2022

    Friedrich D, Marintchev A, Arthanari H. The metaphorical swiss army knife: The multitude and diverse roles of HEAT domains in eukaryotic translation initiation. Nucleic Acids Res. 2022 Jun 10; 50(10):5424-5442. PMID: 35552740.

    Read at: PubMed
  • Published on 12/10/2021

    Paul EE, Lin KY, Gamble N, Tsai AW, Swan SHK, Yang Y, Doran M, Marintchev A. Dynamic interaction network involving the conserved intrinsically disordered regions in human eIF5. Biophys Chem. 2022 02; 281:106740. PMID: 34923394.

    Read at: PubMed
  • Published on 3/26/2020

    Marintchev A, Ito T. eIF2B and the Integrated Stress Response: A Structural and Mechanistic View. Biochemistry. 2020 04 07; 59(13):1299-1308. PMID: 32200625.

    Read at: PubMed
  • Published on 9/26/2018

    Lin KY, Nag N, Pestova TV, Marintchev A. Human eIF5 and eIF1A Compete for Binding to eIF5B. Biochemistry. 2018 10 09; 57(40):5910-5920. PMID: 30211544.

    Read at: PubMed
  • Published on 9/4/2018

    Yu J, Marintchev A. Comparative sequence and structure analysis of eIF1A and eIF1AD. BMC Struct Biol. 2018 09 04; 18(1):11. PMID: 30180896.

    Read at: PubMed
  • Published on 2/20/2018

    Bogorad AM, Lin KY, Marintchev A. eIF2B Mechanisms of Action and Regulation: A Thermodynamic View. Biochemistry. 2018 03 06; 57(9):1426-1435. PMID: 29425030.

    Read at: PubMed
  • Published on 11/16/2017

    Bogorad AM, Lin KY, Marintchev A. Novel mechanisms of eIF2B action and regulation by eIF2a phosphorylation. Nucleic Acids Res. 2017 Nov 16; 45(20):11962-11979. PMID: 29036434.

    Read at: PubMed
  • Published on 6/20/2016

    Nag N, Lin KY, Edmonds KA, Yu J, Nadkarni D, Marintcheva B, Marintchev A. eIF1A/eIF5B interaction network and its functions in translation initiation complex assembly and remodeling. Nucleic Acids Res. 2016 Sep 06; 44(15):7441-56. PMID: 27325746.

    Read at: PubMed
  • Published on 5/20/2014

    Bogorad AM, Xia B, Sandor DG, Mamonov AB, Cafarella TR, Jehle S, Vajda S, Kozakov D, Marintchev A. Insights into the architecture of the eIF2Ba/ß/d regulatory subcomplex. Biochemistry. 2014 Jun 3; 53(21):3432-45. PMID: 24811713.

    Read at: PubMed
  • Published on 1/19/2013

    Marintchev A. Roles of helicases in translation initiation: a mechanistic view. Biochim Biophys Acta. 2013 Aug; 1829(8):799-809. PMID: 23337854.

    Read at: PubMed

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