Dr. Han’s research interests include neurotechnology, optical neural modulation, optogenetics, neural prosthetics, neural network dynamics, brain rhythms, neurological and psychiatric diseases, and cognition.
Brain disorders represent the biggest unmet medical need, with many disorders being untreatable, and most treatments presenting serious side effects. Accordingly, we are discovering design principles for novel neuromodulation therapies. We invent and apply a variety of genetic, molecular, pharmacological, optical, and electrical tools to correct neural circuits that go awry within the brain. As an example, we have pioneered several technologies for silencing specific cells in the brain using pulses of light. We have also recently participated the first pre-clinical testing of a novel neurotechnology, optical neural modulation. Using these novel neurotechnologies and classical ones such as deep brain stimulation (DBS), we modulate the function of neural circuits to establish causal links between neural dynamics and behavioral phenomena (e.g., movement, attention, memory, and decision making). One of our current interests is the investigation of how neural synchrony arises within and across brain regions, and how synchronous activity contributes to normal cognition and pathology.
- Assistant Professor, Pharmacology & Experimental Therapeutics, Boston University School of Medicine
- University of Wisconsin-Madison, PhD
- Beijing University, BS
- Published on 4/4/2015
Kohman RE, Han X. Light sensitization of DNA nanostructures via incorporation of photo-cleavable spacers. Chem Commun (Camb). 2015 Apr 4; 51(26):5747-50. PMID: 25720373.
- Published on 10/20/2014
Bleier BS, Kocharyan A, Singleton A, Han X. Verapamil modulates interleukin-5 and interleukin-6 secretion in organotypic human sinonasal polyp explants. Int Forum Allergy Rhinol. 2015 Jan; 5(1):10-3. PMID: 25330767.
- Published on 8/22/2014
Kocharyan A, Feldman R, Singleton A, Han X, Bleier BS. P-glycoprotein inhibition promotes prednisone retention in human sinonasal polyp explants. Int Forum Allergy Rhinol. 2014 Sep; 4(9):734-8. PMID: 25145685.
- Published on 7/16/2014
Kohman RE, Han X, Bleier BS. Heterotopic mucosal engrafting procedure for direct drug delivery to the brain in mice. J Vis Exp. 2014; (89). PMID: 25077554.
- Published on 7/6/2014
Chuong AS, Miri ML, Busskamp V, Matthews GA, Acker LC, Sørensen AT, Young A, Klapoetke NC, Henninger MA, Kodandaramaiah SB, Ogawa M, Ramanlal SB, Bandler RC, Allen BD, Forest CR, Chow BY, Han X, Lin Y, Tye KM, Roska B, Cardin JA, Boyden ES. Noninvasive optical inhibition with a red-shifted microbial rhodopsin. Nat Neurosci. 2014 Aug; 17(8):1123-9. PMID: 24997763.
- Published on 3/5/2014
Bleier BS, Nocera AL, Iqbal H, Hoang JD, Alvarez U, Feldman RE, Han X. P-glycoprotein promotes epithelial T helper 2-associated cytokine secretion in chronic sinusitis with nasal polyps. Int Forum Allergy Rhinol. 2014 Jun; 4(6):488-94. PMID: 24599606.
- Published on 5/5/2013
Zhang XX, Lamanna CM, Kohman RE, McIntosh TJ, Han X, Grinstaff MW. Lipid-mediated DNA and siRNA Transfection Efficiency Depends on Peptide Headgroup. Soft Matter. 2013 May 05; 9(17). PMID: 24391676.
- Published on 4/24/2013
Bleier BS, Kohman RE, Feldman RE, Ramanlal S, Han X. Permeabilization of the blood-brain barrier via mucosal engrafting: implications for drug delivery to the brain. PLoS One. 2013; 8(4):e61694. PMID: 23637885.
- Published on 4/5/2013
Sun L, Li J, Zhou K, Zhang M, Yang J, Li Y, Ji B, Zhang Z, Zhu H, Yang L, He G, Gao L, Wei Z, Wang K, Han X, Liu W, Tan L, Yu Y, He L, Wan C. Metabolomic analysis reveals metabolic disturbance in the cortex and hippocampus of subchronic MK-801 treated rats. PLoS One. 2013; 8(4):e60598. PMID: 23577129.
- Published on 3/20/2013
Bleier BS, Nocera AL, Iqbal H, Hoang JD, Feldman RE, Han X. P-glycoprotein functions as an immunomodulator in healthy human primary nasal epithelial cells. Int Forum Allergy Rhinol. 2013 Jun; 3(6):433-8. PMID: 23520057.
View 14 more publications: View full profile at BUMC