Wellington V. Cardoso, MD, PhD

Adjunct Professor, Medicine

Wellington Cardoso
(617) 638-6198
72 E. Concord St Housman (R)

Biography

My research focuses on the molecular regulation of progenitor cell fate and morphogenesis in the developing lung and the contribution of developmental signals in lung regeneration and repair mechanisms. Over more than a decade my laboratory investigates the role of developmental pathways, including retinoic acid, Fgfs and Notch, in the establishment of cell fate and patterning of the embryonic lung. These studies have provided insights into specific gene regulatory networks that control induction of the lung primordium, airway branching and differentiation. Currently I direct a Program in Lung Developmental Biology at the Pulmonary Center BUSM, which congregates investigators with knowledge in lung morphogenesis, stem cell biology and regenerative medicine. The overall goals of this Program are to elucidate the properties and fates of lung progenitor cells, to develop tools for their characterization, and to understand the genetic and epigenetic mechanisms that control lineage as the lung forms. Interactions with this group have led to exciting collaborations and exchange of ideas and technologies.

Other Positions

  • Graduate Faculty (Primary Mentor of Grad Students), Boston University School of Medicine, Division of Graduate Medical Sciences
  • Professor, Pathology & Laboratory Medicine, Boston University School of Medicine

Education

  • Universidade de Brasília, MD
  • Universidade de São Paulo, PhD

Publications

  • Published on 7/4/2017

    Mori M, Hazan R, Danielian PS, Mahoney JE, Li H, Lu J, Miller ES, Zhu X, Lees JA, Cardoso WV. Cytoplasmic E2f4 forms organizing centres for initiation of centriole amplification during multiciliogenesis. Nat Commun. 2017 Jul 04; 8:15857. PMID: 28675157.

    Read at: PubMed
  • Published on 5/19/2017

    Stupnikov MR, Cardoso WV. Sensing oxygen inside and out. Elife. 2017 May 19; 6. PMID: 28525315.

    Read at: PubMed
  • Published on 4/11/2017

    Guha A, Deshpande A, Jain A, Sebastiani P, Cardoso WV. Uroplakin 3a+ Cells Are a Distinctive Population of Epithelial Progenitors that Contribute to Airway Maintenance and Post-injury Repair. Cell Rep. 2017 Apr 11; 19(2):246-254. PMID: 28402849.

    Read at: PubMed
  • Published on 8/1/2016

    Marquez HA, Cardoso WV. Vitamin A-retinoid signaling in pulmonary development and disease. Mol Cell Pediatr. 2016 Dec; 3(1):28. PMID: 27480876.

    Read at: PubMed
  • Published on 8/1/2016

    Wagner DE, Cardoso WV, Gilpin SE, Majka S, Ott H, Randell SH, Thébaud B, Waddell T, Weiss DJ. An Official American Thoracic Society Workshop Report 2015. Stem Cells and Cell Therapies in Lung Biology and Diseases. Ann Am Thorac Soc. 2016 Aug; 13(8):S259-78. PMID: 27509163.

    Read at: PubMed
  • Published on 7/27/2016

    Yao Y, Minor PJ, Zhao YT, Jeong Y, Pani AM, King AN, Symmons O, Gan L, Cardoso WV, Spitz F, Lowe CJ, Epstein DJ. Erratum: Cis-regulatory architecture of a brain signaling center predates the origin of chordates. Nat Genet. 2016 Jul 27; 48(8):970. PMID: 27463400.

    Read at: PubMed
  • Published on 6/30/2016

    Tsao PN, Matsuoka C, Wei SC, Sato A, Sato S, Hasegawa K, Chen HK, Ling TY, Mori M, Cardoso WV, Morimoto M. Epithelial Notch signaling regulates lung alveolar morphogenesis and airway epithelial integrity. Proc Natl Acad Sci U S A. 2016 07 19; 113(29):8242-7. PMID: 27364009.

    Read at: PubMed
  • Published on 4/11/2016

    Yao Y, Minor PJ, Zhao YT, Jeong Y, Pani AM, King AN, Symmons O, Gan L, Cardoso WV, Spitz F, Lowe CJ, Epstein DJ. Cis-regulatory architecture of a brain signaling center predates the origin of chordates. Nat Genet. 2016 May; 48(5):575-80. PMID: 27064252.

    Read at: PubMed
  • Published on 7/30/2015

    Szymaniak AD, Mahoney JE, Cardoso WV, Varelas X. Crumbs3-Mediated Polarity Directs Airway Epithelial Cell Fate through the Hippo Pathway Effector Yap. Dev Cell. 2015 Aug 10; 34(3):283-96. PMID: 26235047.

    Read at: PubMed
  • Published on 1/15/2015

    Mori M, Mahoney JE, Stupnikov MR, Paez-Cortez JR, Szymaniak AD, Varelas X, Herrick DB, Schwob J, Zhang H, Cardoso WV. Notch3-Jagged signaling controls the pool of undifferentiated airway progenitors. Development. 2015 Jan 15; 142(2):258-67. PMID: 25564622.

    Read at: PubMed

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