Paul Maglione, MD, PhD
Assistant Professor, Medicine
Biography
Background:
Paul J. (PJ) Maglione, MD, PhD is an Assistant Professor of Medicine in the Section of Pulmonary, Allergy, Sleep & Critical Care Medicine at the Chobanian and Avedisian School of Medicine. He is a physician-scientist with expertise in the clinical care of primary immunodeficiencies and runs a laboratory in the Pulmonary Center at the Boston University Medical Campus. Before arriving at the university, Dr. Maglione was an attending physician and researcher at the Icahn School of Medicine at Mount Sinai. He completed his MD/PhD training at the Albert Einstein College of Medicine and internal medicine residency at Mount Sinai Hospital in New York. Also at Mount Sinai, Dr. Maglione undertook fellowship training in clinical immunology and post-doctoral research under the mentorship of Charlotte Cunningham-Rundles, MD, PhD, a renowned expert in common variable immunodeficiency.
Clinical Focus:
Dr. Maglione is an attending physician at Boston Medical Center where he focuses on the diagnosis and treatment of primary immunodeficiency disorders, with special expertise in the care of common variable immunodeficiency and its complications. He also attends on the inpatient allergy/immunology service. Dr. Maglione is involved in the teaching of allergy/immunology clinical fellows in the Chobanian and Avedisian School of Medicine program. He has been invited to speak to patient audiences on numerous occasions by the Immune Deficiency Foundation, including their national conference, and cares for patients with immune deficiency disorders from around the country.
Research Focus:
Dr. Maglione studies human B cell biology through the lens of primary immunodeficiency. Dr. Maglione’s clinical focus on antibody deficiency syndromes dovetails with his research focus on mechanisms of B cell dysfunction in humans. For numerous years, he has been investigating mechanisms underlying non-infectious complications of the most prevalent form of symptomatic primary antibody deficiency, common variable immunodeficiency (CVID). Recent work has focused upon the pathogenesis of interstitial lung disease affecting CVID patients, particularly upon the biology of B cell dysfunction in this disease. Dr. Maglione has helped devise therapeutic strategies to treat gastrointestinal and pulmonary complications of common variable immunodeficiency. His research utilizes high throughput strategies that include seromics, antibody arrays, genomics, and RNA sequencing coupled with cell culture, biopsies, and information from the medical record to define how B cell defects shape human disease.
Other Positions
- Member, Pulmonary Center, Boston University
- Graduate Faculty (Primary Mentor of Grad Students), Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences
Education
- University of Rochester, BS
- Albert Einstein College of Medicine, MD/PhD
Publications
- Published on 2/19/2025
Faugno E, Galbraith AA, Walsh K, Maglione PJ, Farmer JR, Ong MS. Experiences with diagnostic delay among underserved racial and ethnic patients: a systematic review of the qualitative literature. BMJ Qual Saf. 2025 Feb 19; 34(3):190-200. PMID: 39496473.
Read at: PubMed - Published on 2/12/2025
Gutzeit C, Grasset EK, Matthews DB, Maglione PJ, Britton GJ, Miller H, Magri G, Tomalin L, Stapylton M, Canales-Herrerias P, Sominskaia M, Guzman M, Pybus M, Tejedor Vaquero S, Radigan L, Tachó-Piñot R, Martín Nalda A, García Prat M, Martinez Gallo M, Dieli-Crimi R, Clemente JC, Mehandru S, Suarez-Farinas M, Faith JJ, Cunningham-Rundles C, Cerutti A. Gut IgA functionally interacts with systemic IgG to enhance antipneumococcal vaccine responses. Sci Adv. 2025 Feb 14; 11(7):eado9455. PMID: 39937896.
Read at: PubMed - Published on 1/16/2025
Nieto-Patlán A, Ross J, Mohan S, Paczosa MK, Soliman R, Sarmento O, Aliu E, Thiyagarajan L, Chandra A, Picard C, Warnatz K, Jolles S, Lesmana H, Maglione PJ, Platt CD, Sediva A, Sullivan KE, Zhang K, Raval F, Tangye SG, Abraham RS. Curation of gene-disease relationships in primary antibody deficiencies using the ClinGen validation framework. J Allergy Clin Immunol. 2025 Jan 16. PMID: 39826876.
Read at: PubMed - Published on 1/11/2025
Gilbert KM, LeCates RF, Galbraith AA, Maglione PJ, Argetsinger S, Rider NL, Farmer JR, Ong MS. Diagnostic disparities in inborn errors of immunity: From clinical suspicion to diagnosis. J Allergy Clin Immunol Glob. 2025 May; 4(2):100407. PMID: 39991621.
Read at: PubMed - Published on 12/11/2024
Yin J, Hayes KM, Ong MS, Mizgerd JP, Cunningham-Rundles C, Dominguez I, Barmettler S, Farmer JR, Maglione PJ. Common Variable Immunodeficiency Clinical Manifestations Are Shaped by Presence and Type of Heterozygous NFKB1 Variants. J Allergy Clin Immunol Pract. 2025 Mar; 13(3):639-646. PMID: 39672378.
Read at: PubMed - Published on 4/23/2024
Etesami NS, Barker KA, Shenoy AT, De Ana CL, Arafa EI, Grifno GN, Matschulat AM, Vannini ME, Pihl RMF, Breen MP, Soucy AM, Goltry WN, Ha CT, Betsuyaku H, Browning JL, Varelas X, Traber KE, Jones MR, Quinton LJ, Maglione PJ, Nia HT, Belkina AC, Mizgerd JP. B cells in the pneumococcus-infected lung are heterogeneous and require CD4+ T cell help including CD40L to become resident memory B cells. Front Immunol. 2024; 15:1382638. PMID: 38715601.
Read at: PubMed - Published on 10/12/2023
Sullivan NP, Maniam N, Maglione PJ. Interstitial lung diseases in inborn errors of immunity. Curr Opin Allergy Clin Immunol. 2023 Dec 01; 23(6):500-506. PMID: 37823528.
Read at: PubMed - Published on 10/5/2023
Ong MS, Rider NL, Stein S, Maglione PJ, Galbraith A, DiGiacomo DV, Farmer JR. Racial and ethnic disparities in early mortality among patients with inborn errors of immunity. J Allergy Clin Immunol. 2024 Jan; 153(1):335-340.e1. PMID: 37802474.
Read at: PubMed - Published on 5/8/2023
Bintalib HM, van de Ven A, Jacob J, Davidsen JR, Fevang B, Hanitsch LG, Malphettes M, van Montfrans J, Maglione PJ, Milito C, Routes J, Warnatz K, Hurst JR. Diagnostic testing for interstitial lung disease in common variable immunodeficiency: a systematic review. Front Immunol. 2023; 14:1190235. PMID: 37223103.
Read at: PubMed - Published on 3/8/2023
Chen Y, Bharrhan S, Xu J, Sharma T, Wang Y, Salgame P, Zhang J, Nargan K, Steyn AJC, Maglione PJ, Chan J. B cells promote granulomatous inflammation during chronic Mycobacterium tuberculosis infection in mice. PLoS Pathog. 2023 Mar; 19(3):e1011187. PMID: 36888692.
Read at: PubMed
View 38 more publications: View full profile at BUMC