Nicholas A. Crossland, DVM, DACVP

Assistant Professor, Boston University Chobanian & Avedisian School of Medicine

Biography

Dr. Crossland is a board certified Veterinary Anatomic Pathologist. He shares a dual appointment as an Assistant Professor in the Department of Pathology and Laboratory Medicine at Chobanian and Avedisian School of Medicine and an Investigator at the NEIDL where he directs the NEIDL Comparative Pathology Laboratory (NCPL).

His lab aims to elucidate pathogen-host interactions of highly pathogenic microbes. His lab complements classic pathology approaches with cutting edge technologies such as high throughput tissue staining, spatial transcriptomics and quantitative image analysis. This approach enables the discovery of biological pathways driving and preventing disease. At the translational level, we use our expertise to evaluate the efficacy of medical counter measures with the ultimate goal of alleviating and preventing human suffering.

His lab mentors both MS and PhD students that have their sites on pursuing a career in translational research. He is actively exploring collaborative opportunities with other BUMC faculty members to push the outputs achieved from tissue based assays to drive discovery and enhance our understanding of host-pathogen interactions.

Publications

  • Published 9/8/2025

    Kenney D, O'Connell AK, Tseng AE, Turcinovic J, Sheehan ML, Nitido AD, Montanaro P, Gertje HP, Ericsson M, Connor JH, Vrbanac V, Crossland NA, Harly C, Balazs AB, Douam F. Immune signatures of SARS-CoV-2 infection resolution in human lung tissues. PLoS Pathog. 2025 Sep; 21(9):e1013469. PMID: 40920821.

    Read at: PubMed

  • Published 9/3/2025

    Schwoerer MP, Carver S, Cafiero TR, Joyce B, Berggren KA, Suzuki S, Heller B, O'Connell AK, Gertje HP, Crossland NA, Posfai E, Ploss A. Assessment of hepatitis C virus permissiveness in iteratively genetically humanized mice. J Virol. 2025 Sep 23; 99(9):e0079325. PMID: 40899815.

    Read at: PubMed

  • Published 8/6/2025

    Tseng AE, O'Connell A, Benhamou A, Yabaji S, Kramnik I, Crossland NA, Speranza E. Iterative Bleaching Extends Multiplicity with Use of Staining Automation for Core Facilities. J Vis Exp. 2025 Aug 06; (222). PMID: 40853880.

    Read at: PubMed

  • Published 7/25/2025

    Yabaji SM, Lata S, Gavrish I, Lo M, O'Connell AK, Gertje HP, Thurman CE, Crossland NA, Kobzik L, Kramnik I. Protocol for developing a mouse model of post-primary pulmonary tuberculosis after hematogenous spread in native lungs and lung implants. STAR Protoc. 2025 Jul 25; 6(3):103984. PMID: 40714561.

    Read at: PubMed

  • Published 7/8/2025

    Zhang J, Chavez EC, Winkler M, Liu J, Carver S, Lin AE, Biswas A, Tamura T, Tseng A, Wang D, Benhamou A, O' Connell AK, Matsuo M, Norton JE, Kenney D, Adamson B, Kleiner RE, Burwitz B, Crossland NA, Douam F, Ploss A. Amino acid changes in two viral proteins drive attenuation of the yellow fever 17D vaccine. Nat Microbiol. 2025 Aug; 10(8):1902-1917. PMID: 40629111.

    Read at: PubMed

View All 67 Publications:   View Full Profile in BUMC

Other Positions

  • Faculty, National Emerging Infectious Disease Lab
    Boston University
  • Graduate Faculty (Primary Mentor of Grad Students)
    Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences

Websites

Education

  • Kansas State University, DVM
  • Kansas State University, BS

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