Neil J. Ganem, MD

Assistant Professor, Pharmacology & Experimental Therapeutics

Neil Ganem
(617) 638-5382
72 E. Concord St Silvio Conte (K)

Biography

Dr. Ganem’s laboratory uses a combination of high-resolution microscopy, genome-wide RNAi screening, cell biology, and bioinformatics to study the causes and consequences of genome instability in human cancer. Dr. Ganem’s lab seeks to define the tumor suppression mechanisms that limit the proliferation of highly abnormal aneuploid cells, as well as to identify the common genetic adaptations made by cancer cells to overcome these growth barriers.

Other Positions

  • Assistant Professor, Hematology & Medical Oncology, Medicine, Boston University School of Medicine

Education

  • Geisel School of Medicine, MD
  • University of New Hampshire, BS

Classes Taught

Publications

  • Published on 11/1/2017

    Henssen AG, Reed C, Jiang E, Garcia HD, von Stebut J, MacArthur IC, Hundsdoerfer P, Kim JH, de Stanchina E, Kuwahara Y, Hosoi H, Ganem NJ, Dela Cruz F, Kung AL, Schulte JH, Petrini JH, Kentsis A. Therapeutic targeting of PGBD5-induced DNA repair dependency in pediatric solid tumors. Sci Transl Med. 2017 Nov 01; 9(414). PMID: 29093183.

    Read at: PubMed
  • Published on 9/11/2017

    Grant TJ, Mehta AK, Gupta A, Sharif AAD, Arora KS, Deshpande V, Ting DT, Bardeesy N, Ganem NJ, Hergovich A, Singh A. STK38L kinase ablation promotes loss of cell viability in a subset of KRAS-dependent pancreatic cancer cell lines. Oncotarget. 2017 Oct 03; 8(45):78556-78572. PMID: 29108249.

    Read at: PubMed
  • Published on 11/1/2016

    Lim S, Quinton RJ, Ganem NJ. Nuclear envelope rupture drives genome instability in cancer. Mol Biol Cell. 2016 Nov 01; 27(21):3210-3213. PMID: 27799497.

    Read at: PubMed
  • Published on 1/1/2016

    Bolgioni AF, Ganem NJ. The interplay between centrosomes and the Hippo tumor suppressor pathway. Chromosome Res. 2016 Jan; 24(1):93-104. PMID: 26582635.

    Read at: PubMed
  • Published on 1/1/2016

    Shenk EM, Ganem NJ. Generation and Purification of Tetraploid Cells. Methods Mol Biol. 2016; 1413:393-401. PMID: 27193862.

    Read at: PubMed
  • Published on 3/18/2015

    Russo A, Pacchierotti F, Cimini D, Ganem NJ, Genescà A, Natarajan AT, Pavanello S, Valle G, Degrassi F. Genomic instability: Crossing pathways at the origin of structural and numerical chromosome changes. Environ Mol Mutagen. 2015 Aug; 56(7):563-80. PMID: 25784636.

    Read at: PubMed
  • Published on 1/16/2015

    Flynn RL, Cox KE, Jeitany M, Wakimoto H, Bryll AR, Ganem NJ, Bersani F, Pineda JR, Suvà ML, Benes CH, Haber DA, Boussin FD, Zou L. Alternative lengthening of telomeres renders cancer cells hypersensitive to ATR inhibitors. Science. 2015 Jan 16; 347(6219):273-7. PMID: 25593184.

    Read at: PubMed
  • Published on 11/30/2014

    Lim S, Ganem NJ. Tetraploidy and tumor development. Oncotarget. 2014 Nov 30; 5(22):10959-60. PMID: 25526024.

    Read at: PubMed
  • Published on 8/14/2014

    Ganem NJ, Cornils H, Chiu SY, O'Rourke KP, Arnaud J, Yimlamai D, Théry M, Camargo FD, Pellman D. Cytokinesis failure triggers hippo tumor suppressor pathway activation. Cell. 2014 Aug 14; 158(4):833-48. PMID: 25126788.

    Read at: PubMed
  • Published on 12/10/2012

    Ganem NJ, Pellman D. Linking abnormal mitosis to the acquisition of DNA damage. J Cell Biol. 2012 Dec 10; 199(6):871-81. PMID: 23229895.

    Read at: PubMed

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