Neil J. Ganem, PhD

Associate Professor, Boston University Chobanian & Avedisian School of Medicine

Biography

Dr. Ganem’s laboratory uses a combination of high-resolution microscopy, genome-wide RNAi screening, cell biology, and bioinformatics to study the causes and consequences of genome instability in human cancer. Dr. Ganem’s lab seeks to define the tumor suppression mechanisms that limit the proliferation of highly abnormal aneuploid cells, as well as to identify the common genetic adaptations made by cancer cells to overcome these growth barriers.

Publications

  • Published 8/31/2026

    Mutha D, Vedula CP, Bhagavatula S, Grinstaff MW, Wong WW, Lu D, Ganem NJ, Flynn RL. Genetic Medicine Approaches for Tumor Suppressor Loss: Therapeutic Replacement with Self-Amplifying RNA. Pharm Res. 2026 Aug; 43(8):2529-2551. PMID: 42675373.

    Read at: PubMed

  • Published 3/21/2026

    Gu Y, Choi J, Mutha D, Wu C, Ganem NJ, Grinstaff M, Wong W. Self-amplifying RNA-based CAR T cell therapy with enhanced duration and multi-genic logic functions. bioRxiv. 2026 Mar 21. PMID: 41756931.

    Read at: PubMed

  • Published 9/14/2023

    Vittoria MA, Quinton RJ, Ganem NJ. Whole-genome doubling in tissues and tumors. Trends Genet. 2023 Dec; 39(12):954-967. PMID: 37714734.

    Read at: PubMed

  • Published 6/15/2023

    Vedula CP, Ganem NJ. CIP2A and TOPBP1: Molecular lassos that herd pulverized micronuclear chromosomes. Mol Cell. 2023 Jun 15; 83(12):1964-1966. PMID: 37327773.

    Read at: PubMed

  • Published 3/23/2023

    Laroche FJF, Li S, Shen N, Hwang SK, Nguyen G, Yu W, Wong CK, Quinton RJ, Berman JN, Liu CT, Singh A, Ganem NJ, Thiagalingam S, Feng H. S1P1 Threonine 236 Phosphorylation Mediates the Invasiveness of Triple-Negative Breast Cancer and Sensitivity to FTY720. Cells. 2023 Mar 23; 12(7). PMID: 37048053.

    Read at: PubMed

View All 36 Publications:   View Full Profile in BUMC

Other Positions

  • Associate Professor, Medicine
    Boston University Chobanian & Avedisian School of Medicine
  • Member, BU-BMC Cancer Center
    Boston University
  • Member, Genome Science Institute
    Boston University
  • Graduate Medical Sciences Educator and Mentor (Primary Mentor of Graduate Students)
    Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences

Websites

Education

  • Geisel School of Medicine, PhD
  • University of New Hampshire, BS

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