Glaucoma is a leading cause of blindness worldwide. A primary risk factor for the development and progression of primary open-angle glaucoma (POAG) is elevation of intraocular pressure (IOP), which resulted from increased aqueous outflow resistance. However, the cause of this elevated aqueous outflow resistance in POAG remains unknown. The research in our laboratory is focused on understanding the mechanisms that regulate aqueous humor outflow resistance in normal eyes and how this resistance is increased in POAG in order to provide new insights for developing new therapeutic strategies to lower IOP.
- Professor, Anatomy & Neurobiology, Boston University School of Medicine
- Graduate Faculty (Primary Mentor of Grad Students), Boston University School of Medicine, Division of Graduate Medical Sciences
- Jiangxi University of Traditional Chinese Medicine, MD
- Boston University School of Medicine, PhD
- Peking Union Medical College, MS
- Published on 10/30/2017
Raghunathan V, Eaton JS, Christian BJ, Morgan JT, Ver Hoeve JN, Yang CC, Gong H, Rasmussen CA, Miller PE, Russell P, Nork TM, Murphy CJ. Biomechanical, ultrastructural, and electrophysiological characterization of the non-human primate experimental glaucoma model. Sci Rep. 2017 Oct 30; 7(1):14329. PMID: 29085025.
- Published on 11/1/2016
Ren R, Li G, Le TD, Kopczynski C, Stamer WD, Gong H. Netarsudil Increases Outflow Facility in Human Eyes Through Multiple Mechanisms. Invest Ophthalmol Vis Sci. 2016 Nov 01; 57(14):6197-6209. PMID: 27842161.
- Published on 1/13/2016
Cha ED, Xu J, Gong L, Gong H. Variations in active outflow along the trabecular outflow pathway. Exp Eye Res. 2016 May; 146:354-60. PMID: 26775054.
- Published on 1/1/2016
Gong H and Swain DL. The histopathological changes in the trabecular outflow pathway and their possible effects on aqueous outflow in eyes with primary open-angle glaucoma. Glaucoma Research and Clinical Advances 2016-2018. Kugler. Amsterdam. 2016; 17-40.
- Published on 8/31/2015
Pizzirani S, Gong H. Functional Anatomy of the Outflow Facilities. Vet Clin North Am Small Anim Pract. 2015 Nov; 45(6):1101-26, v. PMID: 26337760.
- Published on 2/10/2015
Swain DL, Ho J, Lai J, Gong H. Shorter scleral spur in eyes with primary open-angle glaucoma. Invest Ophthalmol Vis Sci. 2015 Mar; 56(3):1638-48. PMID: 25670488.
- Published on 12/17/2014
Vargas-Pinto R, Lai J, Gong H, Ethier CR, Johnson M. Finite element analysis of the pressure-induced deformation of Schlemm's canal endothelial cells. Biomech Model Mechanobiol. 2015 Aug; 14(4):851-63. PMID: 25516410.
- Published on 9/9/2014
Yang CY, Huynh T, Johnson M, Gong H. Endothelial glycocalyx layer in the aqueous outflow pathway of bovine and human eyes. Exp Eye Res. 2014 Nov; 128:27-33. PMID: 25217864.
- Published on 1/24/2014
Gong H, Yang CY. Morphological and hydrodynamic correlations with increasing outflow facility by rho-kinase inhibitor Y-27632. J Ocul Pharmacol Ther. 2014 Mar-Apr; 30(2-3):143-53. PMID: 24460021.
- Published on 1/1/2014
Gong H and Francis A. Surgical Innovations in Glaucoma. Schlemm’s Canal and Collector Channels as Therapeutic Targets. Springer. New York. 2014; 3-25.
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