Felicia Chen, MD

Assistant Professor, Medicine

(617) 638-6739
72 E. Concord St Housman (R)

Biography

Dr. Chen attends on the Pulmonary Consult service and in the Medical Intensive Care Units at Boston Medical Center and Sturdy Memorial Hospital. She is a member of Dr. Wellington V. Cardoso’s lab.

The abnormalities of the developing respiratory system associated with retinoic acid (RA)-deficiency have been known for decades. However, the cellular and molecular events controlled by RA during lung development remain unclear. Dr. Chen’s research focuses on the various RA-dependent signaling mechanisms involved in primary lung bud formation. By using a combination of pharmacologic, genetic, and organ culture approaches, she has demonstrated the critical role of RA in controlling at least three major pathways, Tgf-beta, Wnt, and Fgf, to allow proper formation of the early lung. Currently, she’s investigating the role of retinoic acid in the differentiation of bronchial and vascular smooth muscles during lung development.

Special interests include:
-Mechanisms of primary lung bud induction
-Lung progenitor biology
-Role of retinoic acid in early lung development
-Lung injury and repair

Other Positions

  • Courtesy Staff Privileges, Medicine, Boston Medical Center

Education

  • Albany Medical College, MD
  • Johns Hopkins University, BA

Publications

  • Published on 8/11/2016

    Chen F, Fine A. Stem Cells in Lung Injury and Repair. Am J Pathol. 2016 Oct; 186(10):2544-50. PMID: 27524796.

    Read at: PubMed
  • Published on 1/1/2015

    Chen F, Cardoso WV. Culture of mouse embryonic foregut explants. Methods Mol Biol. 2015; 1189:163-9. PMID: 25245693.

    Read at: PubMed
  • Published on 5/17/2010

    Chen F, Cao Y, Qian J, Shao F, Niederreither K, Cardoso WV. A retinoic acid-dependent network in the foregut controls formation of the mouse lung primordium. J Clin Invest. 2010 Jun; 120(6):2040-8. PMID: 20484817.

    Read at: PubMed
  • Published on 12/1/2009

    Shi W, Chen F, Cardoso WV. Mechanisms of lung development: contribution to adult lung disease and relevance to chronic obstructive pulmonary disease. Proc Am Thorac Soc. 2009 Dec 1; 6(7):558-63. PMID: 19934349.

    Read at: PubMed
  • Published on 8/11/2008

    Tsao PN, Chen F, Izvolsky KI, Walker J, Kukuruzinska MA, Lu J, Cardoso WV. Gamma-secretase activation of notch signaling regulates the balance of proximal and distal fates in progenitor cells of the developing lung. J Biol Chem. 2008 Oct 24; 283(43):29532-44. PMID: 18694942.

    Read at: PubMed
  • Published on 7/18/2007

    Chen F, Desai TJ, Qian J, Niederreither K, Lü J, Cardoso WV. Inhibition of Tgf beta signaling by endogenous retinoic acid is essential for primary lung bud induction. Development. 2007 Aug; 134(16):2969-79. PMID: 17634193.

    Read at: PubMed
  • Published on 1/19/2006

    Desai TJ, Chen F, Lü J, Qian J, Niederreither K, Dollé P, Chambon P, Cardoso WV. Distinct roles for retinoic acid receptors alpha and beta in early lung morphogenesis. Dev Biol. 2006 Mar 1; 291(1):12-24. PMID: 16427040.

    Read at: PubMed
  • Published on 8/26/2005

    Lü J, Qian J, Chen F, Tang X, Li C, Cardoso WV. Differential expression of components of the microRNA machinery during mouse organogenesis. Biochem Biophys Res Commun. 2005 Aug 26; 334(2):319-23. PMID: 16036130.

    Read at: PubMed

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