Dr. Chen attends in the Intensive Care Unit at Boston Medical Center. She also provides pulmonary and critical care consultative services at Sturdy Memorial Hospital and an affiliated rehabilitation hospital.
Dr. Chen’s laboratory projects focus on the role of retinoic acid, the natural active metabolite of vitamin A, in embryonic lung development and postnatal lung health. Dr. Chen uses a multifaceted approach to achieve retinoic acid deficiency in mouse models for her studies, including dietary deprivation of vitamin A, pharmacologic blockade of retinoic acid synthesis and receptor activation, as well as genetic modification. Her current projects include the regulatory properties of retinoic acid on 1) airway smooth muscle homeostasis, 2) pulmonary vascular smooth muscle phenotypes, 3) embryonic airway epithelial specification, and 4) pulmonary lymphatic endothelial development.
Special interests include:
-Vitamin A and retinoid biology
-Embryonic lung development
-Lung injury and repair
-Fibrotic lung diseases
- Courtesy Staff Privileges, Medicine, Boston Medical Center
- Albany Medical College, MD
- Johns Hopkins University, BA
- Published on 8/23/2018
Chen F, Shao F, Hinds A, Yao S, Ram-Mohan S, Norman TA, Krishnan R, Fine A. Retinoic acid signaling is essential for airway smooth muscle homeostasis. JCI Insight. 2018 Aug 23; 3(16). PMID: 30135301.
- Published on 9/18/2017
Wasserman GA, Szymaniak AD, Hinds AC, Yamamoto K, Kamata H, Smith NM, Hilliard KL, Carrieri C, Labadorf AT, Quinton LJ, Ai X, Varelas X, Chen F, Mizgerd JP, Fine A, O'Carroll D, Jones MR. Expression of Piwi protein MIWI2 defines a distinct population of multiciliated cells. J Clin Invest. 2017 Oct 02; 127(10):3866-3876. PMID: 28920925.
- Published on 8/11/2016
Chen F, Fine A. Stem Cells in Lung Injury and Repair. Am J Pathol. 2016 Oct; 186(10):2544-50. PMID: 27524796.
- Published on 1/1/2015
Chen F, Cardoso WV. Culture of mouse embryonic foregut explants. Methods Mol Biol. 2015; 1189:163-9. PMID: 25245693.
- Published on 1/9/2014
Chen F, Marquez H, Kim YK, Qian J, Shao F, Fine A, Cruikshank WW, Quadro L, Cardoso WV. Prenatal retinoid deficiency leads to airway hyperresponsiveness in adult mice. J Clin Invest. 2014 Feb 3; 124(2):801-11. PMID: 24401276.
- Published on 5/17/2010
Chen F, Cao Y, Qian J, Shao F, Niederreither K, Cardoso WV. A retinoic acid-dependent network in the foregut controls formation of the mouse lung primordium. J Clin Invest. 2010 Jun; 120(6):2040-8. PMID: 20484817.
- Published on 12/1/2009
Shi W, Chen F, Cardoso WV. Mechanisms of lung development: contribution to adult lung disease and relevance to chronic obstructive pulmonary disease. Proc Am Thorac Soc. 2009 Dec 1; 6(7):558-63. PMID: 19934349.
- Published on 8/11/2008
Tsao PN, Chen F, Izvolsky KI, Walker J, Kukuruzinska MA, Lu J, Cardoso WV. Gamma-secretase activation of notch signaling regulates the balance of proximal and distal fates in progenitor cells of the developing lung. J Biol Chem. 2008 Oct 24; 283(43):29532-44. PMID: 18694942.
- Published on 7/18/2007
Chen F, Desai TJ, Qian J, Niederreither K, Lü J, Cardoso WV. Inhibition of Tgf beta signaling by endogenous retinoic acid is essential for primary lung bud induction. Development. 2007 Aug; 134(16):2969-79. PMID: 17634193.
- Published on 1/19/2006
Desai TJ, Chen F, Lü J, Qian J, Niederreither K, Dollé P, Chambon P, Cardoso WV. Distinct roles for retinoic acid receptors alpha and beta in early lung morphogenesis. Dev Biol. 2006 Mar 1; 291(1):12-24. PMID: 16427040.
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