Dr. Chen’s laboratory projects focus on retinoic acid biology in healthy and diseased lungs. She uses a multifaceted approach to knock down retinoic acid signals in mouse models for her studies, including dietary deprivation of vitamin A, pharmacologic blockade of retinoic acid synthesis and receptor activation, as well as genetic modifications. Her current projects include the regulatory properties of retinoic acid on 1) airway smooth muscle homeostasis, 2) lung microbiome, 3) embryonic airway epithelial specification, and 4) matrix fibroblast activation.
Special interests include:
-Vitamin A and retinoid biology
-Embryonic lung development
-Lung injury and repair
-Fibrotic lung diseases
- Courtesy Staff Privileges, Medicine, Boston Medical Center
- Member, Pulmonary Center, Boston University
- Member, Evans Center for Interdisciplinary Biomedical Research, Boston University
- Albany Medical College, MD
- Johns Hopkins University, BA
- Published on 1/1/2020
Marquez HA, Chen F. Retinoic Acid Signaling and Development of the Respiratory System. Subcell Biochem. 2020; 95:151-174. PMID: 32297299.
- Published on 5/13/2019
Norman TA, Gower AC, Chen F, Fine A. Transcriptional landscape of pulmonary lymphatic endothelial cells during fetal gestation. PLoS One. 2019; 14(5):e0216795. PMID: 31083674.
- Published on 8/23/2018
Chen F, Shao F, Hinds A, Yao S, Ram-Mohan S, Norman TA, Krishnan R, Fine A. Retinoic acid signaling is essential for airway smooth muscle homeostasis. JCI Insight. 2018 08 23; 3(16). PMID: 30135301.
- Published on 9/18/2017
Wasserman GA, Szymaniak AD, Hinds AC, Yamamoto K, Kamata H, Smith NM, Hilliard KL, Carrieri C, Labadorf AT, Quinton LJ, Ai X, Varelas X, Chen F, Mizgerd JP, Fine A, O'Carroll D, Jones MR. Expression of Piwi protein MIWI2 defines a distinct population of multiciliated cells. J Clin Invest. 2017 Oct 02; 127(10):3866-3876. PMID: 28920925.
- Published on 8/11/2016
Chen F, Fine A. Stem Cells in Lung Injury and Repair. Am J Pathol. 2016 Oct; 186(10):2544-50. PMID: 27524796.
- Published on 1/1/2015
Chen F, Cardoso WV. Culture of mouse embryonic foregut explants. Methods Mol Biol. 2015; 1189:163-9. PMID: 25245693.
- Published on 1/9/2014
Chen F, Marquez H, Kim YK, Qian J, Shao F, Fine A, Cruikshank WW, Quadro L, Cardoso WV. Prenatal retinoid deficiency leads to airway hyperresponsiveness in adult mice. J Clin Invest. 2014 Feb 3; 124(2):801-11. PMID: 24401276.
- Published on 5/17/2010
Chen F, Cao Y, Qian J, Shao F, Niederreither K, Cardoso WV. A retinoic acid-dependent network in the foregut controls formation of the mouse lung primordium. J Clin Invest. 2010 Jun; 120(6):2040-8. PMID: 20484817.
- Published on 12/1/2009
Shi W, Chen F, Cardoso WV. Mechanisms of lung development: contribution to adult lung disease and relevance to chronic obstructive pulmonary disease. Proc Am Thorac Soc. 2009 Dec 1; 6(7):558-63. PMID: 19934349.
- Published on 8/11/2008
Tsao PN, Chen F, Izvolsky KI, Walker J, Kukuruzinska MA, Lu J, Cardoso WV. Gamma-secretase activation of notch signaling regulates the balance of proximal and distal fates in progenitor cells of the developing lung. J Biol Chem. 2008 Oct 24; 283(43):29532-44. PMID: 18694942.
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