Felicia Chen, MD

Assistant Professor, Medicine

Felicia Chen
72 E. Concord St Housman (R)

Biography

Dr. Chen’s laboratory projects focus on retinoic acid biology in healthy and diseased lungs. She uses a multifaceted approach to knock down retinoic acid signals in mouse models for her studies, including dietary deprivation of vitamin A, pharmacologic blockade of retinoic acid synthesis and receptor activation, as well as genetic modifications. Her current projects include the regulatory properties of retinoic acid on 1) airway smooth muscle homeostasis, 2) lung microbiome, 3) embryonic airway epithelial specification, and 4) matrix fibroblast activation.

Special interests include:
-Vitamin A and retinoid biology
-Embryonic lung development
-Lung homeostasis
-Lung injury and repair
-Fibrotic lung diseases
-Asthma

Other Positions

  • Courtesy Staff Privileges, Medicine, Boston Medical Center
  • Member, Pulmonary Center, Boston University
  • Member, Evans Center for Interdisciplinary Biomedical Research, Boston University

Education

  • Albany Medical College, MD
  • Johns Hopkins University, BA

Classes Taught

  • GMSMM725

Publications

  • Published on 1/1/2020

    Marquez HA, Chen F. Retinoic Acid Signaling and Development of the Respiratory System. Subcell Biochem. 2020; 95:151-174. PMID: 32297299.

    Read at: PubMed
  • Published on 5/13/2019

    Norman TA, Gower AC, Chen F, Fine A. Transcriptional landscape of pulmonary lymphatic endothelial cells during fetal gestation. PLoS One. 2019; 14(5):e0216795. PMID: 31083674.

    Read at: PubMed
  • Published on 8/23/2018

    Chen F, Shao F, Hinds A, Yao S, Ram-Mohan S, Norman TA, Krishnan R, Fine A. Retinoic acid signaling is essential for airway smooth muscle homeostasis. JCI Insight. 2018 08 23; 3(16). PMID: 30135301.

    Read at: PubMed
  • Published on 9/18/2017

    Wasserman GA, Szymaniak AD, Hinds AC, Yamamoto K, Kamata H, Smith NM, Hilliard KL, Carrieri C, Labadorf AT, Quinton LJ, Ai X, Varelas X, Chen F, Mizgerd JP, Fine A, O'Carroll D, Jones MR. Expression of Piwi protein MIWI2 defines a distinct population of multiciliated cells. J Clin Invest. 2017 Oct 02; 127(10):3866-3876. PMID: 28920925.

    Read at: PubMed
  • Published on 8/11/2016

    Chen F, Fine A. Stem Cells in Lung Injury and Repair. Am J Pathol. 2016 Oct; 186(10):2544-50. PMID: 27524796.

    Read at: PubMed
  • Published on 1/1/2015

    Chen F, Cardoso WV. Culture of mouse embryonic foregut explants. Methods Mol Biol. 2015; 1189:163-9. PMID: 25245693.

    Read at: PubMed
  • Published on 1/9/2014

    Chen F, Marquez H, Kim YK, Qian J, Shao F, Fine A, Cruikshank WW, Quadro L, Cardoso WV. Prenatal retinoid deficiency leads to airway hyperresponsiveness in adult mice. J Clin Invest. 2014 Feb 3; 124(2):801-11. PMID: 24401276.

    Read at: PubMed
  • Published on 5/17/2010

    Chen F, Cao Y, Qian J, Shao F, Niederreither K, Cardoso WV. A retinoic acid-dependent network in the foregut controls formation of the mouse lung primordium. J Clin Invest. 2010 Jun; 120(6):2040-8. PMID: 20484817.

    Read at: PubMed
  • Published on 12/1/2009

    Shi W, Chen F, Cardoso WV. Mechanisms of lung development: contribution to adult lung disease and relevance to chronic obstructive pulmonary disease. Proc Am Thorac Soc. 2009 Dec 1; 6(7):558-63. PMID: 19934349.

    Read at: PubMed
  • Published on 8/11/2008

    Tsao PN, Chen F, Izvolsky KI, Walker J, Kukuruzinska MA, Lu J, Cardoso WV. Gamma-secretase activation of notch signaling regulates the balance of proximal and distal fates in progenitor cells of the developing lung. J Biol Chem. 2008 Oct 24; 283(43):29532-44. PMID: 18694942.

    Read at: PubMed

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