Catherine E. Costello, PhD

William Fairfield Warren Distinguished Professor, Biochemistry

Catherine Costello
(617) 638-6490
670 Albany St Biosquare III


Catherine Costello came to Boston University in 1994. That year she established the Center for Biomedical Mass Spectrometry, which has become an internationally recognized research center. She holds her primary appointment in the MED Biochemistry Department, with secondary appointments in the Department of Physiology & Biophysics and the Department of Chemistry. Her research, which focuses on determining the structures and functions of biologically important polymers, has revolutionized an important area of biochemistry by providing insights into the structures of molecules responsible for human disease. She is the author or co-author of more than 300 scientific papers, serves on a number of editorial boards of major journals, and has received numerous awards and honors, including the 2010 Field and Franklin Award from the American Chemical Society, one of the highest honors in her field.

Other Positions

  • Research Professor, Physiology & Biophysics, Boston University School of Medicine
  • Director, Mass Spectrometry Research, Mass Spectrometry, Boston University School of Medicine
  • Graduate Faculty (Primary Mentor of Grad Students), Boston University School of Medicine, Division of Graduate Medical Sciences


  • Emmanuel College, AB
  • Georgetown University, MS
  • Georgetown University, PhD

Classes Taught

  • BI793


  • Published on 7/3/2015

    Baker ES, Burnum-Johnson KE, Ibrahim YM, Orton DJ, Monroe ME, Kelly RT, Moore RJ, Zhang X, Th├ęberge R, Costello CE, Smith RD. Enhancing bottom-up and top-down proteomic measurements with ion mobility separations. Proteomics. 2015 Aug; 15(16):2766-76.

    Read at: PubMed
  • Published on 5/22/2015

    Th├ęberge R, Dikler S, Heckendorf C, Chui DH, Costello CE, McComb ME. MALDI-ISD Mass Spectrometry Analysis of Hemoglobin Variants: a Top-Down Approach to the Characterization of Hemoglobinopathies. J Am Soc Mass Spectrom. 2015 Aug; 26(8):1299-310.

    Read at: PubMed
  • Published on 5/20/2015

    Ji Y, Liu M, Bachschmid MM, Costello CE, Lin C. Surfactant-Induced Artifacts during Proteomic Sample Preparation. Anal Chem. 2015 Jun 2; 87(11):5500-4.

    Read at: PubMed
  • Published on 10/8/2014

    Rahimi N, Costello CE. Emerging roles of post-translational modifications in signal transduction and angiogenesis. Proteomics. 2015 Jan; 15(2-3):300-9.

    Read at: PubMed
  • Published on 8/13/2014

    de Souza EE, Meirelles GV, Godoy BB, Perez AM, Smetana JH, Doxsey SJ, McComb ME, Costello CE, Whelan SA, Kobarg J. Characterization of the human NEK7 interactome suggests catalytic and regulatory properties distinct from those of NEK6. J Proteome Res. 2014 Sep 5; 13(9):4074-90.

    Read at: PubMed
  • Published on 7/31/2014

    Jiang J, Tian F, Cai Y, Qian X, Costello CE, Ying W. Site-specific qualitative and quantitative analysis of the N- and O-glycoforms in recombinant human erythropoietin. Anal Bioanal Chem. 2014 Oct; 406(25):6265-74.

    Read at: PubMed
  • Published on 6/4/2014

    Zhou Y, Park H, Kim P, Jiang Y, Costello CE. Surface oxidation under ambient air--not only a fast and economical method to identify double bond positions in unsaturated lipids but also a reminder of proper lipid processing. Anal Chem. 2014 Jun 17; 86(12):5697-705.

    Read at: PubMed
  • Published on 5/21/2014

    Huang Y, Pu Y, Yu X, Costello CE, Lin C. Mechanistic study on electron capture dissociation of the oligosaccharide-Mg2+ complex. J Am Soc Mass Spectrom. 2014 Aug; 25(8):1451-60.

    Read at: PubMed
  • Published on 4/24/2014

    Bourgoin-Voillard S, Leymarie N, Costello CE. Top-down tandem mass spectrometry on RNase A and B using a Qh/FT-ICR hybrid mass spectrometer. Proteomics. 2014 May; 14(10):1174-84.

    Read at: PubMed
  • Published on 3/20/2014

    York WS, Agravat S, Aoki-Kinoshita KF, McBride R, Campbell MP, Costello CE, Dell A, Feizi T, Haslam SM, Karlsson N, Khoo KH, Kolarich D, Liu Y, Novotny M, Packer NH, Paulson JC, Rapp E, Ranzinger R, Rudd PM, Smith DF, Struwe WB, Tiemeyer M, Wells L, Zaia J, Kettner C. MIRAGE: the minimum information required for a glycomics experiment. Glycobiology. 2014 May; 24(5):402-6.

    Read at: PubMed

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