Boston University Medical Campus
Pathology and Laboratory Medicine

Pathology & Laboratory Medicine News Items

Announcements:

• Ivana Delalle, MD; PhD has been promoted to Associate Professor
• Drs. Shinichiro Kurosawa and Deborah J Stearns-Kurosawa were awarded a NIH/NIAID sub-contract from ProThera Biologics (Pawtucket, RI) from the STTR proposal “Role of Inter-alpha Inhibitors in Anthrax Intoxication”.   This is a collaborative project with Dr. Yow-Pin Lim of Prothera Biologics and Dr. Steven Opal of the Warren Alpert Medical School of Brown University.
• Carl O’Hara, M.D., has been appointed as the Vice Chair of Education
• Antonio de las Morenas, M.D., has been appointed as the Vice Chair of Diversity and Faculty Development
• Sandra Cerda, M.D. has been appointed as the Director of the Pathology Residency Program
• Daniel Remick, M.D., has been elected as a Council Member for the Association of Pathology Chairs and Chair of the Advocacy Committee
• Carmen Sarita-Reyes, M.D. has been appointed as Fourth Year Clerkship Director in Pathology and Laboratory Medicine
• Michael Roehrl, MD; PhD had received the Young Investigator Award, Human Proteome Organization (HUPO) and International Forum for Proteomics
• A T32 training grant was funded, T32GM86308, “Immunobiology of Trauma”, Principal Investigator Daniel Remick, M.D. This grant will provide 2 years of training in basic science laboratories to train the next generation of physician scientist
• Ivana Delalle, MD; PhD has just been awarded an NIH Grant; R21 MH86079-01 (Delalle, Ivana):“Exosomal and cell-class specific miRNA profiles in bipolar disorder and schizophrenia”
• Four new faculty members have either recently arrived, or will be arriving shortly. Here is information about the newest members of our Department.
  • Evrim Erdogan, Ph.D. The Department of Pathology and Laboratory Medicine of Boston University School of Medicine is pleased to announce the appointment of Evrim Erdogan, Ph.D. as an Assistant Professor of Pathology and Laboratory Medicine. Dr. Erdogan received her Ph.D. in Clinical-Bioanalytical Chemistry from Cleveland State University. This was followed by a post-doctoral fellowship in clinical chemistry at the ARUP laboratories at the University of Utah. Dr. Erdogan is a diplomat of the American Board of Clinical Chemistry. She has been appointed as the Co-Director of Clinical Chemistry in the Department of Laboratory Medicine of Boston Medical Center.
  • Tiffany Mellot, Ph.D. The Department of Pathology and Laboratory Medicine is pleased to announce the appointment of Tiffany Mellot, Ph.D., as a Research Assistant Professor of Pathology and Laboratory Medicine. Dr. Mellot received a B.S. in biochemistry/molecular biology from the University of Pittsburgh, graduating magna cum laude. She received her Ph.D. in pathology and neuroscience from Boston University followed by a post-doctoral fellowship with Dr. Blusztajn in our department. She has published numerous papers examining the effects of choline supplementation on neuronal development.
  • Marianna Ruzinova, M.D., Ph.D. The Department of Pathology and Laboratory Medicine is pleased to announce the recruitment of Marianna Ruzinova, M.D., Ph.D. as an Assistant Professor. Dr. Ruzinova received a degree in biochemistry from Swarthmore College. She obtained her M.D., Ph.D. from Weill Cornell Medical College and then completed training in anatomic and clinical pathology at the Brigham and Women’s Hospital where she was Chief Resident.  She is board certified in both clinical and anatomic pathology. Dr. Ruzinova recently completed a hematopathology fellowship, also at Brigham and Women’s Hospital. She will become the Medical Director of Clinical Hematology and will also participate in signing hematopathology and surgical pathology cases.
  • Susan Winandy, Ph.D., First Bucher Assistant Professor of Pathology and Laboratory Medicine. The Department of Pathology and Laboratory Medicine is pleased to announce Susan Winandy, Ph.D. as the first Nancy L. R. Bucher Assistant Professor. Dr. Winandy obtained a Bachelor’s of Science degree from the University of Connecticut and a Ph.D. in Biology from the Massachusetts Institute of Technology. Following a post-doctoral fellowship at the Massachusetts General Hospital/Harvard Medical school she assumed a position as an Assistant Professor in the Department of Microbiology – Immunology at the Northwestern University Feinberg School of Medicine. Dr. Winandy has been active in teaching and has served on several thesis committees as well as being an advisor to several students. Her teaching excellence was recognized by the receipt of the Outstanding Teacher for lectures to medical students in the Immunology section. Dr. Winandy’s research investigates how the molecule Ikaros regulates the immune response. She has served on study sections for the National Institutes of Health and currently is an Associate Editor for the Journal of Immunology.
• Congratulations on passing the Qualifying Exams!
  • Rituparna Moitra
• David Stepien, incoming MD/PhD student has just been elected to be the MD PhD Student Executive Committee member for the next two years
• New Student Orientation Day is Tuesday, August 31st.  I would like to invite you for a casual “Meet & Greet” with our new PhD students from 2:30 – 3:30 PM in the 4th floor Conference Room here at 670 Albany. Why don’t you plan to join us: MARK YOUR CALENDARS!!!

Presentations:

• Michael Roehrl, MD; PhD, has been invited to present at the HUPO 2010 International Meeting, Sydney, Australia, September 2010; “Glycoproteomics of lung cancer”
• Heather Cohen, PhD candidate, Trojanowska Lab will be presenting a poster at the 11th International Workshop on Scleroderma Research; Boston, Massachusetts; August 1-4, 2010. Her abstract title is: “Characterization of ECM gene expression in a Fli1 knockdown mouse model of fibrosis”
• American Journal of Clinical Pathology Editorial Board has named as one of the 10 finalists for the AJCP Resident Research Symposium Award to be held at the annual meeting of the ASCP October 27-31, 2010; “Prediction Of Final Grade In Adenocarcinoma Of Endometrium Using P53, Ki-67 and Zeb1 Immunostains In Preoperative Biopsies” by resident Marier Hernandez-Perez, MD and Antonio De Las Morenas, MD The competition is scheduled for Saturday, October 30
• Daniel Remick, M.D., presented Grand Rounds at Temple University in the Department of Pathology “Sepsis and the Complex Inflammatory Response”.

Publications-ACCEPTED:

• Accepted in Shock, “Adenosine Negative Feedback On A2A Adenosine Receptors Mediates Hypo-Responsiveness In Chronically Septic Mice” Bryan Belikoff, Stephen Hatfield, and Michail Sitkovsky, and Daniel G. Remick
• Accepted in the American Journal of Pathology “Assessing Pulmonary Pathology by Detailed Examination of Respiratory Function,” Louis J. Vaickus, Jacqueline Bouchard, Jiyoun Kim, Sudha Natarajan and Daniel G. Remick
• Dr. Karen Quillen has had a paper accepted for publication in Transfusion: Quillen K, Medrano C, Adams S, Peterson B, Hackett JA, Leitman SF, Klein HG, Stroncek DF. “Screening plateletpheresis donors for HLA antibodies on two high throughput platforms and correlation with recipient outcome”

Pathology & Laboratory Medicine News Items

Announcements:

• As of July 1st, Martin Kroll, MD is the Chair of the Northeast Section of the American Association for Clinical Chemistry
• On Sunday September 26 Dr. Leonard Berman will be honored at the Massachusetts/Rhode Island branch of the New York University Medical Alumni Association annual brunch here at the Boston Harbor Hotel
• Daniel Remick, MD organized and chaired a Symposium at the Shock Society’s 33rd Annual Conference on Shock, titled “Where are they now? Updates from Previous New Investigator Awardees”
• Dr. Daniel Remick also presented Grand Rounds at Temple University in Philadelphia. The title of his talk was “Sepsis, Complex inflammation for a complex disease”
• After its successful inspection by the Mayo Labs for the CAP, Laboratory Medicine has received a full accreditation
• Daniel Remick, MD moderated a mini-symposium at the same conference “Organ Dysfunction – Mechanisms and Therapies”
• The Community Health Centers Laboratories, under the direction of Michael Roehrl, MD, PhD, had a successful inspection from the Joint Commission
• Martin Kroll, MD was recently elected to the nominating committee of the AACC (American Association for Clinical Chemistry) Critical and Point of Care Testing
• Welcome to new faculty member Evrim Erdogan, MD; Associate Director of Clinical Chemistry
• Congratulations on passing the Qualifying Exams!
  • Atsushi Ebata
  • Ed Hartsough
  • Tricia Kao
  • Sri Srinivasan
    • Thank you to all faculty members who assisted with the qualifying exams, with a special Thank You Dr. Bohdana Burke
• The summer has a flurry of activities going on with students interning from high schools and colleges in several pathology labs!
  • The Office of Summer Term’s program, Research Internship in Science and Engineering, is once again in full swing offering rising high school seniors the opportunity to participate in basic science research for six weeks.  Forty-three students are places throughout the BU community and the following six are place in the Pathology and Immunology Departments:
    • Gabe Beaudoin in the Remick Lab hails from Marin Academy in Marin, CA
    • Greta Gadbois in the Kurosawa Lab arrives from Amesbury High in Amesbury, MA
    • Corey Shih in the Cruickshank Lab comes from Monta Vista High in Cupertino, CA
    • Shannon McCarthy in the Blusztajn Lab hails from Austin Preparatory School in Reading, MA
    • Rebecca Dale in the Berse Lab comes from Noble and Greenough School in Dedham, MA
    • Sabrina Rangi in the Rifkin Lab arrives from Owosso High in Owosso, MI
  • Valencia Potter and Mychelle Williams from Xavier University in Louisiana are here in the Remick Lab as part of the Graduate Medical Sciences Summer Research Program
  • John Kim, PhD in the Remick Lab has college student Doo-Yong Bradley Choi, currently a Junior at the University of Waterloo, Ontario, Canada interning/working on “Expression and purification of a recombinant protein from bacteria”

Presentations:

• Dr. Lija Joseph’s abstract entitled “Association Between Insulin Resistance and Macrophage-Mediated Inflammation in Subcutaneous and Visceral Fat Depots in Obese Individuals ” was accepted for poster presentation at The Obesity Society’s 2010 Annual Scientific Meeting in San Diego, California, October 8-12
• Martin Kroll, MD recently presented at the ASCP Workshop for Laboratory Professionals in Newark, NJ.  The title of his all day presentation was “Quality Control and Method Evaluation.”
• Dr. Sun-Young Oh from the Kurosawa Lab presented two posters at the 33rd Annual Shock Society Conference in Portland, Oregon, June 2-7, 2010:
• S-Y. Oh*, D. Weiner, D.J. Stearns-Kurosawa, S. Kurosawa. DIFFERENTIAL CYTOKINE RESPONSES IN BABOONS FOLLOWING SHIGA TOXIN TYPE-1 AND -2 CHALLENGE.
• D.J. Stearns-Kurosawa V. Collins, S.Freeman, S-Y. Oh*, S. Kurosawa. DISTINCT PATHOPHYSIOLOGIC RESPONSES IN BABOONS AFTER CHALLENGE WITH SHIGA TOXIN TYPE-1 OR -2.

Publications-PUBLISHED:

• Roehrl MHA & Wang JY. “Immature Granulocytes in Pregnancy: A Story of Virchow, Anxious Fathers, and Expectant Mothers.” American Journal of Hematology 2010 (in press).
• Srisawasdi P, Chaichanajarernkul U, Teerakanjana N, Vanavanan S, Kroll MH.  “Exogenous interferences with Jaffe creatinine assays: addition of sodium dodecyl sulfate to reagent eliminates bilirubin and total protein interference with Jaffe methods. “ Journal of Clinical Laboratory Analysis.  2010;24:123-133

Publications-ACCEPTED:

• Just accepted for publication in Journal of Clinical Microbiology (ASM Press):  “Corynebacterium falsenii bacteremia occurring in an infant on vancomycin therapy”  Pui-Ying Iroh Tam, Mark A Fisher, Nancy S Miller Louis Vaickus, MD/PhD, Remick Lab just had has paper; “Assessing Pulmonary Pathology by Detailed Examination of Respiratory Function” accepted for publication to the American Journal of Pathology. It was the first of 4 papers he submitted for review; we’ll have to wait to see about the others
• Bryan Belikoff’s, MD/PhD, Remick Lab paper submitted to Shock; “Adenosine Negative Feedback On A2A Adenosine Receptors Mediates Hypo-Responsiveness In Chronically Septic Mice” has been accepted for publication

Pathology & Laboratory Medicine News Items

Announcements:

• Susan Winandy, Ph.D., First Bucher Assistant Professor of Pathology and Laboratory Medicine

The Department of Pathology and Laboratory Medicine is pleased to announce Susan Winandy, Ph.D. as the first Nancy L. R. Bucher Assistant Professor. Dr. Winandy obtained a Bachelor’s of Science degree from the University of Connecticut and a Ph.D. in Biology from the Massachusetts Institute of Technology. Following a post-doctoral fellowship at the Massachusetts General Hospital/Harvard Medical school she assumed a position as an Assistant Professor in the Department of Microbiology – Immunology at the Northwestern University Feinberg School of Medicine. Dr. Winandy has been active in teaching and has served on several thesis committees as well as being an advisor to several students. Her teaching excellence was recognized by the receipt of the Outstanding Teacher for lectures to medical students in the Immunology section. Dr. Winandy’s research investigates how the molecule Ikaros regulates the immune response. Her work has appeared in top tier journals such as the Journal of Immunology, Journal of Experimental Medicine, and the Journal of Biological Chemistry. More than two dozen peer-reviewed manuscripts have been published by Dr. Winandy in addition to several editorials and book chapters. She has served on study sections for the National Institutes of Health and currently is an Associate Editor for the Journal of Immunology.

The Nancy L.R. Bucher Assistant Professorship in Pathology was named for Nancy Bucher, M.D., Research Professor of Pathology and Laboratory Medicine at Boston University School of Medicine. Dr. Bucher enjoys an international reputation for her pioneering research on liver regeneration and the growth of cancer cells. She joined the Department 26 years ago and continues to serve as a distinguished member of the faculty. This named Professorship appropriately acknowledges her long-standing contributions to the research mission of the Department. Established with anonymous contributions, the Nancy L. R. Bucher Assistant Professorship Fund in Pathology is a permanently endowed fund, the income of which provides salary and research resources to a junior faculty member for three to five years. The fund also benefits from the generous challenge grant to establish endowed positions throughout the University. The challenge grant was given by former BU Board of Trustees Chair Alan Leventhal and his wife, Sherry, who is Vice Chair of the BUSM Dean’s Advisory Board.

“Professorships are important to the mission of the School of Medicine because they support the research work of biomedical scientists,” said Dean Karen Antman. “They offer BUSM the opportunity to attract highly distinguished researchers.”

• Dr Chris Andry was recently notified that he is a recipient of a Strategic International Partner Fellowship at the Institute for Advanced Studies, Warwick University, UK.  Dr Andry will travel to Warwick to work with a colleague, Dr Rodger Charlton on two areas of mutual interest “Cultural Competency and Care of the Deceased Patient and their Family” and “The Role of the Decedent Affairs Office in Operational Improvement at Boston Medical Center”.

There exist similarities and extreme differences between the USA and the UK regarding management of deceased patients, which makes this field of study particularly interesting.  Understanding decisions about death, bereavement and burial, in the context of cultural preferences, is just one example of an opportunity for research that would benefit physicians and health care workers in many countries.
Dr Andry plans to present on behalf of the Decedent Affairs Office Team (Chris Kiriakos and the Off Shift Nurse Managers) that the role of the DAO at Boston Medical Center is to always ensure that whatever processes govern a patient’s care after death, they must always be performed with dignity and with the best interests of the patient and their family at heart.

• Congratulations to this year’s recipients of Henry I. Russek Student Achievement Awards in the Department of Pathology:
  • First Prize- Madhumita Jagannathan – Congratulations!~
  • Second Prize- Jillian Richmond – Bravo!~
  • Honorable Mention- Supraja Narasimhan – Great work!

As described by the founder of the Student Achievement Awards program, Dr. Shelley Russek, Professor of Pharmacology at the Medical School, “…[T]hese Achievement Awards go to students who have distinguished themselves not only as gifted researchers in their mentor’s laboratory but also as dedicated members of their department and/or program.”  More information about the Russek Awards can be found at this link <http://www.bumc.bu.edu/gms/achievement-day-2010/>

• June is PhD Qualifying Exams Month! This year June 2nd will be the written part of the exam and June 8th and 9th the oral portion will take place. There are six students who will be taking their qualifying exams this season: Dominic Beal, Atsushi Ebata, Ed Hartsough, Tricia Kao, Ritu Moitra and Sri Srinivasan. The faculty working with this group of candidates is: Drs. Berse, Burke, Murnane, Rahimi, Remick, and Slack. Good Luck to all! Thank you to Dr. Bohdana Burke for all of her hard work coordinating!
• Martin Steffen, PhD will have a feature article profiling his lab’s gene function validation in The Scientist, with an embargo date on May 27. Reporter Jef Akst recently interviewed Martin and his team for a feature news story. A link to this article will be provided next New News issue.
• The Kurosawa Lab welcomes Ms. Ishbel “Bella” Heru as a part-time research technician.  Bella is a graduate of BU and comes to us most recently from Brown University with experience in a crystallography lab.
• Congratulations  to Besam Khidhir, MD/PhD Candidate who successfully Defended his thesis “Radiologic Localization of Pathologic Lesions Using Image Registration” on May 24th; Besam will be returning to Medical School in June
• Congratulations  to Lou Vaickus, MD/PhD Candidate who successfully Defended his thesis “Cockroach Allergens Induce a Biphasic Asthmatic Response” on May 25th; Lou will be returning to Medical School in June
• We are inviting all graduate students to join our New Graduate Student Discussion Board, open to all current and inquiring students about our program. The expectation is that students will pose questions and we will answer (in a timely manner).  This will allow, especially inquiring students, to get immediate answers to questions that may not be readily available on our web page or that is unique to him/her. We encourage your input since you are in the trenches and can probably answer many of these questions best!!! We are also welcoming any BUSM or Boston, “Did you know…” items. Please send to dekiley@bu.edu . Feedback about how the Discussion Board is going will be appreciated. Here is the link:
• Graduation Photos

Catherine Cory, MA and Dr. Daniel Remick, Chair Pathology and Laboratory Medicine	Elizabeth Schuller, MA and her fiancé James Duffy Chris Andry, PhD, Director Masters Program,

• Barbara Nikolajczyk, PhD will be sitting on the Special Emphasis Panel for review of NIH Immunology IRG conflicts in July
• Barbara Nikolajczyk, PhD received a Boston Area Diabetes and Endocrinology Research Center Pilot grant entitled, “The role of B cell in  mouse model of type 2 diabetes”
• Michael Roehrl, MD; PhD was elected Member of the Executive Committee, Massachusetts Medical Society International Medical Graduate Section (MMS-IMG), Waltham, MA. Term: 2010-2013
• Michael Roehrl, MD; PhD was named Faculty Research Fellow by the Karin Grunebaum Cancer Research Foundation (http://www.grunebaumfoundation.org/); funding for experimental laboratory research, 2010-2011
• Diana Weiner, Lab Tech in the Kurosawa Lab has just been accepted into The University of Pittsburgh School of Medicine
• Barbara Nikolajczyk’s, PhD R21 entitled “The role of B cells and B cell Toll-like receptors in glucose intolerance” has been selected for funding by the National Institute of Diabetes and Digestive Disorders

Presentations:

• Dr Chris Andry was an invited speaker at Thermo Scientific Day in April.  He gave a seminar on operational improvement in an anatomic pathology laboratory. The presentation focused on a historical retrospective of the Mallory Institute of Pathology, the design of the new laboratory space at 670 Albany Street, the department’s focus and interest in employee and patient safety, and tools to assist with error reduction such as bar coding technology.
• Maria Panchenko, PhD will present a poster at the 75th Symposium: Nuclear Organization & Function meeting in Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, June 2-8, 2010 “JADE protein family in the histone acetyl transferase (HAT) HBO1 complex and the cell cycle” by M.V. Panchenko and S. Mitra
• Karen Quillen, MD presented at the Beckman Coulter Scientific Meeting on Sepsis in Barcelona on May 3-4: the work presented was conducted by former residents John Lee, MD (graduating cytology fellow), Sara Koenig, MD, Bethany Tierno, MD, Robert Bagdasaryan, MD and Fernando Chaves, MD; supervised by former faculty DongSheng Xu, MD, PhD. Aside from the residents’ hard work, a certain amount of luck was involved getting to and from Europe in between volcanic ash eruptions
• Carmen Sarita-Reyes, MD and resident Yanelba Toribio, MD has a case of Juvenile Nasopharyngeal Angiofibroma that was accepted for the Slide Survey of the Society of Pediatric Pathology (SSO SPP) 2010.
• John Kim, PhD, Assistant Professor recently visited Korea and made four different presentations:
  • “Indoor Allergens, Air Pollutants, and Asthma.” Korea Institute of Science and Technology, Seoul, Korea, May 4, 2010
  • “Air Pollution, Oxidative Stress, Asthma, and Anti-oxidant Treatment.” Division of Pulmonology, Gacheon University of Medicine and Sciences, Incheon, Korea. May 6, 2010
  • “Cockroach Allergen, Asthma, and Air Pollution.” Department of Biology, Suncheon National University, Suncheon, Korea. May 10, 2010
  • “Indoor Allergens, Air Pollutants, and Asthma.” Department of Biological Sciences, Sookmyung University, Seoul, Korea, May 12, 2010

• Several members of the Remick Lab will be presenting individual posters at this year’s SHOCK Society Convention in Portland June 12-15th:
  • Brian Japp: “Abundant Protein Depletion Also Dramatically Depletes Target Cytokines”
  • Liz Schuller, MA: “Delayed Addition of Dimethyl Sulphoxide Fails to Modulate Cytokine Production in a Human Whole Blood Model”
  • Florin Craciun, PhD candidate will present and have a poster: “Pulmonary Consequences of Murine Sepsis: Injury or Just Inflammation”

• A poster presentation based on an innovative method of cadaver biopsy in medical school curriculum has been accepted for discussion at the 2010 John McCahan Medical Campus Education Day. The project was initiated by Dr. Lija Joseph and was supported partially by a grant that she received from the American Society for Investigative Pathology toward developing medical student interest in pathology.    Please plan to attend the Medical Education day on June 11th , 2010 by registering at http://www.bu.edu/jmedday/index.htm

Publications-ACCEPTED:

• Barbara Nikolajczyk, PhD has had a publication accepted to Cytokine. Nikolajczyk, BS. 2010. “B cells as unappreciated mediators of human non-autoimmune inflammatory disease.” Cytokine. (In Press)
• Barbara Nikolajczyk, PhD has also had the following article accepted to FEBS Letters. Denis, GV, Nikolajczyk, BS, Schnitzler, G. 2010. “An emerging role for bromodomain-containing proteins in chromatin regulation and transcriptional control of adipogenesis.” FEBS Letters (In Press).
• Zhang Q, Radisalvjevic Z, Siroky M and Azadzoi K: “Dietary Antioxidants Improve Arteriogenic Erectile Dysfunction” has been accepted for publication in the International Journal of Andrology
• Aletta Schnitzler, PhD in the Blusztajn Lab just had a paper accepted: Schnitzler AC, Mellott TJ, Lopez-Coviella I, Tallini Y, Kotlikoff M, Follettie M, Blusztajn JK (2010) “BMP9 induces NGF as an autocrine/paracrine cholinergic trophic factor in developing basal forebrain neurons.” J Neurosci In press.
• Michael Roehrl, MD; PhD has a paper accepted: Roehrl, Lantz, Sylvester, Wang. “Age-Dependent Reference Ranges for Automated Assessment of Immature Granulocytes and Clinical Significance in an Outpatient Setting.” Archives of Pathology and Laboratory Medicine, 2010, in press. Great example of research with our Community Health partners!

Pathology & Laboratory Medicine News Items

Announcements:

• Correction with great apologies to Dr. Lija Joseph for not properly identifying her as Hematology Lab Section Director in an April’s New News article (reprinted appropriately below).  KUDOS to Dr. Joseph!!~!!! Because of Dr. Lija Joseph’s Hematology Lab’s excellent performance in Hematology Cell Identification, the College of American Pathologists (CAP) has invited the Hematology Section of Laboratory Medicine to become a referee for the 2010 Survey year. Referees are selected participants with a record of perfect performance on graded cell identification challenges from the preceding years. These referees serve as “experts” who perform a valuable service to evaluate the images used in the CAP Surveys Program. As a participant in the College of American Pathologists (CAP) Hematology (FH Series) Survey, you may be aware of our referee laboratories that provide data for cell identification. With CLIA-88 regulations governing consensus for qualitative proficiency testing, the role of referees is particularly important. Again, Congratulations to Dr. Joseph and her team!
• Barbara Nikolajczyk, PhD will be chairing the block symposium on “Lymphocyte/APC migration” at the 97th Annual Meeting of The American Association of Immunologists, May 9th in Baltimore, MD!!
• Jillian Richmond, PhD Candidate has been awarded the National Science Foundation GK-12 Fellowship offered through the Boston University Project STAMP/Boston Urban Fellows Program. Jillian will receive financial support for the 2010-2011 academic year, and she will teach in a Boston Public High School part-time. This includes assisting high school teachers with enhancing their curricula and assisting with labs and science fairs. The program website is here:  Bravo Jillian!
• The Kurosawa Lab enthusiastically welcomes Diann Henthorn.  Diann will assist with the nonhuman primate studies at the Oklahoma site.  If you’re ever in Oklahoma, please stop by to say “hey” to Diann.   Her email is:  diannh@bu.edu. And, yes, it is Diann.  Not Dianne, Diane or Diana.
• A new postdoc Han-Pil Choi joins the Steffen Lab on May 1. Han-Pil has been working at Yale Medical School with Dr. John MacMicking, helping to identifying downstream IFN pathways that are crucial for controlling infection of macrophages and dendritic cells by Mycobacterium tuberculosis (Mtb), the causative agent of TB.
• Congratulations  to Bryan Belikoff, MD/PhD Candidate successfully Defended his thesis “Regulation of the Immunosuppressive Hypoxia-A2 Adenosinergic Pathway: A Potential Therapeutic Target for the Treatment of Bacterial Sepsis” on April 19th
• Congratulations to Catherine Cory for completing her requirements and thesis “The Antioxidant Taurine Reduces Pulmonary Inflammation And Airway Hyperresponsiveness In a Mouse Model Of Asthma” to receive her MA in Pathology

Presentations:

• Jillian Richmond, PhD candidate will be presenting 2 posters at the American Association of Immunologists 97th Meeting in Baltimore, MD May 7-11,
• Richmond, J, J Lee, D Green, H Kornfeld, W Cruikshank. “Mannose lipoarabinomannan from Mycobacterium tuberculosis inhibits T cell migration to sphingosine-1-phosphate and promotes trapping of T cells in lung draining lymph nodes”
• Richmond, J, E Schuller, J Lee, D Remick, H Kornfeld, W Cruikshank. “Mannose lipoarabinomannan from Mycobacterium tuberculosis promotes production of soluble TNF Receptors I & II”

Publications-PUBLISHED:

• Madhu Jagannatham, PhD candidate had her paper published, “Toll-like receptors regulate B cell cytokine production in patients with diabetes”.  Jagannathan M, McDonnell M, Liang Y, Hasturk H, Hetzel J, Rubin D, Kantarci A, Van Dyke TE, Ganley-Leal LM, Nikolajczyk BS. Diabetologia. 2010 Apr 11.

Publications-ACCEPTED:

• Resident Dehua Wang’s MD manuscript entitled “Prevalence of RhD Variants, Confirmed by Molecular Genotyping, in a Multi-ethnic Prenatal Population” by Wang D, Lane C, Quillen K has been accepted for publication in the American Journal of Clinical Pathology
• Resident Marier Hernandez-Perez MD has a manuscript accepted for publication in The International Journal of Dermatology. “CUTANEOUS LEPIDOPTERISM: DERMATITIS FROM CONTACT WITH MOTHS OF Hylesia metabus (Cramer 1775) (Lepidoptera: Saturniidae), THE  CAUSATIVE AGENT OF CARIPITO ITCH” by Alberto E. Paniz-Mondolfi, Alexandra M. Pérez-Alvarez, Ulf Lundberg, Lizette Fornés, Oscar Reyes-Jaimes, Marier Hernández-Pérez and Eric Hossler.
• Former graduate student Devin Horton, has a paper accepted in Clinical and Vaccine Immunology, “Delayed Addition of Glucocorticoids Selectively Suppresses Cytokine Production in Stimulated Human Whole Blood,” Devin L. Horton and Daniel G. Remick.

Pathology & Laboratory Medicine News Items –

Announcements

• Dr. Daniel Remick has been invited to give the 8th Annual John Spitzer Distinguished Lecture, Louisiana State University Health Sciences Center, March 25, 2010 in New Orleans. The title of his presentation is:  Sepsis Complex Inflammation for a Complex Disease
• Dr. Remick also served as a moderator at the 8th Congress on Trauma, Shock, Injury and Sepsis, Munich Germany, on Immune Dysfunction in Sepsis in Injury Animals/Patients: Update on Immunopathogenesis and Pathophysiology.
• Dr. Remick was invited to give two presentations at the 8th Congress on Trauma, Shock, Injury and Sepsis, Munich Germany, Pulmonary Endotoxin Tolerance – Spare the Lung but Kill the Bacteria and Lessons Learned from Experimental Peritonitis Models
• Dr. Remick organized a symposium for the Association of Investigative Pathology at the 2010 Experimental Biology meeting to be held in Anaheim, California. The session is titled: Genetics and Molecular Biomarkers of Disease and Nanotechnology
• Because of Dr. Martin Kroll’s lab’s excellent performance in Hematology Cell Identification, the College of American Pathologists (CAP) has invited the Hematology section of Laboratory Medicine to become a referee for the 2010 Survey year. Referees are selected participants with a record of perfect performance on graded cell identification challenges from the preceding years. These referees serve as “experts” who perform a valuable service to evaluate the images used in the CAP Surveys Program. As a participant in the College of American Pathologists (CAP) Hematology (FH Series) Survey, you may be aware of our referee laboratories that provide data for cell identification. With CLIA-88 regulations governing consensus for qualitative proficiency testing, the role of referees is particularly important.
• The Tissue Dispensary celebrated its one-year anniversary with a perfect record in tracking the use of Tissue in surgery.  Lisa O’Connor said “I am so proud of this!! You all have done an outstanding job.”  James Becker, MD, Chair of Surgery said “I agree with al the kudos that have been voiced. This was a terrific team effort.”   Special thanks go to Carol Cohen, our Medical Technologist, Mark Flomenbaum, our Medical Director, Kate Murphy, our Supervisor of the Blood Bank, and to Janet Means and Dr. Chris Andry, for their tremendous support, and to the staff in the Blood Bank, for making this program a success.
• In Laboratory Medicine, we had our CAP inspection on March 1st, by the Mayo Clinic Reference Laboratory. We did exceptionally well and they gave us high praises on the way the laboratory is run. Our thanks to the staff, faculty and administration, who make our laboratory exceptional in its delivery of care every day!!!
• The Kurosawa and Geisbert labs were awarded a joint 7-year NIH contract for developing “Animal Models of Disease”.   Co-PIs on the contract are Shinichiro Kurosawa, MD, PhD; Deborah J Stearns-Kurosawa, PhD; Thomas Geisbert and Katherine Bossart.
• Shinichiro Kurosawa and Deborah J Stearns-Kurosawa are collaborators on an NIH STTR grant with PI Steven Opal, MD (Memorial Hospital, RI) and ProThera Biologics (RI) to study the influence of a protease inhibitor on disease progression during bacteria infection.
• Janet Means received her official letter of appointment to the Department of Public Health Clinical Laboratory Advisory Committee from the DPH commissioner. The multidisciplinary committee was convened to review and revise state laboratory regulations. It is a three year appointment commencing April 1. Congratulation Janet from Dr. Remick and Dr. Kroll!

  From Dr. Kroll, “Congratulations!!! You will provide great expertise, knowledge and judgment to the committee.  The State and the Public will be greatly served. They are lucky to have you serve on the committee!”

Presentations

• Ivana Delalle, MD, PhD is giving an invited lecture at the Institute of Neuropathology, Zurich, Switzerland, on April 8.
• Zach Hunter, MA student, is first author in the Poster Presentation at the American Society of Clinical Oncology (ASCO) Permanent Abstract ID:  8108 Abstract Title: “The attainment of CR/VGPR is associated with significantly longer progression free survival in rituximab-naive WM patients undergoing rituximab-based therapy, and is predicted by polymorphisms in FcGRIIIA-158”
• Zach Hunter, MA student has been invited to give a talk on Clinical Charactaristics and Genetics of Familial WM at the annual International Waldenstrom’s Macroglobulinemia Foundation’s Educational Forum in Las Vegas on April 10th

Publications-ACCEPTED

• DJ Stearns-Kurosawa, PhD, Valta Collins, Scott Freeman, Vernon L. Tesh, Shinichiro Kurosawa, MD, PhD. “Distinct Physiologic and Inflammatory Responses Elicited in Baboons after Challenge with Shiga Toxin Type-1 or -2 from Enterohemorrhagic E.coli”  Infection and Immunity, in press
• Quiroz R, Joseph L, Sam F Serial Troponin-I Measurement as a Diagnostic and Therapeutic Tool in Chronic Myocarditis. Has been accepted for publication in Journal of Heart and Lung Transplantation, 2010
• Lazar HL, Joseph L, San Mateo C, Frame J, Cabral HJ, McDonnell M, Chipkin S. Expression of Inducible Nitric Oxide Synthase in Conduits Used in Patients with Diabetes Mellitus Undergoing Coronary Revascularization. J Card Surg 2010; 25:120-126

Pathology & Laboratory Medicine News Items

• Bryan Belikoff MD/PhD Candidate, Remick Lab, who has just started as a pre-doc on the hematology training grant, has just won a travel award to a national meeting. The committee can feel good about selecting a great applicant who has already paid off dividends.
• Dr. Carmen Sarita-Reyes has just been appointed member of the Education Committee of the Society of Pediatric Pathology beginning March 2010 for a three year period.
• Dr. Michael Roehrl received a 1-year Junior Investigator Institutional Research Grant from the American Cancer Society. The title of the grant is “Tissue Proteomic Discovery of Biomarkers of Colorectal Adenocarcinoma”.
• Dr. Ivana Delalle has been invited to lecture on March 30.  She will be guest of Professor Charles Duyckaerts at Hospital La Salpetriere, Paris, France.
• Dr. Lija Joseph has been appointed as an academy advisor at the BU school of medicine. She is also coordinating a session at the APC national meeting at seattle this july. “Diagnostic Rotation:  Time for a new requirement”
• Madhu Jagannathan PhD candidate been accepted to do an oral presentation at the 97th Annual Meeting of The American Association of Immunologists, May 7th-11th in Baltimore, MD.

Publications – Accepted

• Michael Greene Phd Candidate abstract titled: “Histopathologic and Serologic Evidence for a Role of the Molecular Chaperone Clusterin in Amyloidotic Cardiomyopathy.” has been accepted for presentation at the XIIth International Symposium on Amyloidosis April 18th-21st in Rome, Italy. In addition he has been awarded The Chip Miller Memorial Junior Research Travel Award by the Amyloidosis Foundation.
• Dr. Remick has a Paper accepted in the journal SHOCK.  “UNTREATED TYPE 1 DIABETES INCREASES SEPSIS-INDUCED MORTALITY WITHOUT INDUCING A PRE-LETHAL CYTOKINE RESPONSE”
  • Marcin F. Osuchowski,*† Florin L. Craciun,* Elizabeth Schuller,* Corneliu Sima ,‡ Robert Gyurko,‡ and Daniel G. Remick* Departments of *Pathology and ‡Laboratory Medicine and Periodontology and Oral Biology, Boston University School of Medicine, Boston, Massachusetts, USA, and †Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, Vienna, Austria
• Sun-Young Oh PhD from the  Kurosawa Lab had a publication accepted to the Journal of Neurochemistry this month. J Neurochem. 2010 Jan 20 [Epub ahead of print] “Cell-type Dependent Modulation of Notch Signaling by Amyloid Precursor Protein. Oh SY, Chen CD, Abraham CR.”
• Quadfecta – 4 submitted Abstracts 4 Oral Presentations at the Environmental Biology Conference.
  • A trifecta refers to selecting three winners in a row.  So while quadfecta is not a word, it accurately describes the outcome of the abstracts submitted to the 2010 Experimental Biology Meeting in Anaheim this April. Four Abstracts were submitted to the meeting from the Remick Lab and all four were selected for Oral Presentations. Here are the details:
    • “Oral Tolerance Reduces Pulmonary Inflammation in a Cockroach Antigen Murine Model of Allergic Asthma.”
      Louis Vaickus, Jacqueline Bouchard, Jiyoun Kim, Sudha Natarajan, Daniel G. Remick
    • “Binge drinking exacerbates asthmatic-like pulmonary inflammation in cockroach-allergen (CRA) induced allergic mice”
      Jacqueline Bouchard, Jiyoun Kim, Louis Vaickus, Daniel Remick
    • “Adenosine A2B Receptor Expression by Myeloid Cells Mediates Airway Inflammation in Asthma”
      Bryan Belikoff, Louis Vaickus, Michail Sitkovsky, and Daniel Remick
    • “Antibodies to TNF-α Soluble Receptors Exacerbate Airway Inflammation in a Mouse Model of Asthma”
      Jiyoun Kim, Louis Vaickus, Jacqueline Bouchard, Elizabeth Schuller, Daniel Remick

Publications – Published

• A manuscript by Kazem Azadzoi, M.D. et al entitled “Oxidative Stress and Neurodegeneration in Penile Ischemia” has been published in the March issue of the British Journal of Urology 105: 404-410, 2010.

Announcements

• Audrey Quinn, Assistant Supervisor in the Microbiology Clinical Laboratory received her RN degree.  We all fill a little safer working when she is around….
• New initiative in bringing pathology to the third and fourth year medical students.    The education team in the department  is planning a creative curricular program integrating pathology in the radiology rotation for BUSM 3 students.   Specific lab exercises are being developed to simulate actual clinical case workup scenario one afternoon a month.   Please let Drs. Joseph (lija.joseph@bmc.org) or O’Hara (carl.ohara@bmc.org)  know if you are interested in participating in the planning and development of this new project.   We plan to launch it in fall of 2010.
• Fiona Chiem, a BU senior working with Dr. John Kim in the Remick Lab has won the “Student Research Award from the Undergraduate Research Opportunity Program” (UROP) at Boston University.
• Liz Schuller, MA has been chosen to be the Research Internship Coordinator for the BU Summer Term Program.  This program places highly qualified high school seniors in laboratories for a six week period during the summer to conduct research in various fields.  Liz will be in charge of admission and lab placement.

Publications

• Weber HC. “Editorial overview: gastrointestinal regulatory peptides.”  Current Opinion  Endocrinology Diabetes Obes. 2010 Feb;17(1):31-2. PubMed PMID: 19996968.
• Flicker MS, Weber HC. “Endoscopic hemostasis in a case of bleeding from Zenker’s diverticulum.”  Gastrointest Endosc. 2009 Nov 16. [Epub ahead of print] PubMed PMID: 19922922.
• Majumdar ID, Weber HC. ” Gastrointestinal regulatory peptides and their effects on fat tissue.” Current Opinion Endocrinology Diabetes Obes. 2010 Feb;17(1):51-6.  PubMed PMID: 19855273.
• Lazar HL, Joseph L, San Mateo C, Frame J, Cabral HJ, McDonnell M, Chipkin S. “Expression of Inducible Nitric Oxide Synthase in Conduits Used in Patients with Diabetes Mellitus Undergoing Coronary Revascularization.” J Card Surg 2010; 25:120-126
• Pornpen Srisawasdi, PhD, Somlak Vanavanan, MSc, Charaslak Charoenpanichkit, MD, and Martin H. Kroll, MD “The Effect of Renal Dysfunction on BNP, NT-proBNP, and Their Ratio. ” American Journal of Clinical Pathology 2010; 133:14-23
• Martin H. Kroll, MD “Multiple Patient Samples of an Analyte Improve Detectionof Changes in Clinical Status” Archive of Pathology and Laboratory Medicine. 2010;134:81–89
• Papageorgis, P., A.W. Lambert, S. Ozturk, F. Gao, H. Pan,  U. Manne, Y.O. Alekseyev, A. Thiagalingam, H. Abdolmaleky, M. Lenburg, and S. Thiagalingam. 2010.  Smad signaling is required for maintenance of epigenetic gene silencing during breast cancer progression. Cancer Res. 70(3): 968-978.
• Quiroz R, Joseph L, Sam F :” Serial Troponin-I Measurement as a Diagnostic and Therapeutic Tool in Chronic Myocarditis  submitted to the Journal of Heart and Lung Transplantation.”   Submitted 1/19/10
• A manuscript by Kazem Azadzoi, M.D. et al entitled “Oxidative Modification of Mitochondrial Integrity and Nerve Fiber Density in the Ischemic Overactive Bladder” has been published in the January issue of the Journal of Urology 183 (1):362-369, 2010.

Pathology & Laboratory Medicine News Items – January 2010

Announcements:

• The Department of Pathology and Laboratory Medicine of Boston University School of Medicine and Boston Medical Center is pleased to continue its strong record of accepted abstracts at the annual meeting of the United States and Canadian Academy of Pathology. The 2010 meeting will be held March 20 to 26, 2010 in Washington DC. Daniel Remick, M.D., has been asked to serve on the abstract review panel for the annual meeting. Here is the list of accepted publications:

• Asthma Research from the Remick Lab is highlighted in Boston University’s 2009 Annual Report,   The information is listed as #18.
• Michael Roehrl, MD, PhD received a Travel Award for Mass Spectrometry: Applications to the Clinical Laboratory 2010 to the MSACL 2010 Meeting in March 2010
• Aditi Gurkar, PhD successfully defended her thesis  “ATM/ATR-mediated Phosphorylation of Rad18 is Required for Efficient S-phase Progression and Replication Fork Stability”on December 1, 2009

Presentations:

• Michael Roehrl, MD, PhD is has been invited to give a Platform Presentation (“Glycoproteomics of Lung Cancer”), at the USCAP 2010 Meeting

Publications-PUBLISHED:

• Robert Pistey, MD has a paper recently published in Annals of Otology, Rhinology and Laryngology 118 (11):817-826. Title: “Anatomy-Based Algorithms for Detecting Oral Cancer Using Reflectance and Fluorescence Spectroscopy.” Authors: Sasha McGee, PhD; Vartan Mardirossian, MD; Alphi Elackattu, MD; Jelena Mirkovic, PhD; Robert Pistey, MD, MA; George Gallagher, DMD, DMSc; Sadru Kabani, DMD, MA; Chung-Chieh Yu, PhD; Zimmern Wang, MD; Kamran Badizadegan, MD; Gregory Grillone, MD; Michael S. Feld, PhD:
• Mary Jo Murnane, PhD had an article published in the Dec 15 issue of the International Journal of Cancer:  “Active MMP-2 Effectively Identifies the Presence of Colorectal Cancer.” Authors: Mary Jo Murnane, Jinguo Cai, Sania Shuja, David McAneny,   Veronica Klepeis and John B. Willett
• Martin Steffen, MD, PhD, has had three paper recently accepted for publication.  BRAVO!

1. Nature Chemical Biology 2010 Jan;6 (1):4-5. doi:10.1038/nchembio.288. Title: “Biochemical networks: The evolution of gene annotation.” Authors: Simon Kasif1 & Martin Steffen2
2. Eukaryot Cell. 2009 Nov 30. Title: “Evidence for mucin-like glycoproteins that tether sporozoites of Cryptosporidium parvum to the inner surface of the oocyst wall.” Authors: Chatterjee A, Banerjee S, Steffen M, O’Connor RM, Ward HD, Robbins PW, Samuelson J.
3. Eukaryot Cell. 2009 Oct 16. [Epub ahead of print] Title:  “Suggestive evidence for Darwinian selection against asparagine-linked glycans of  Plasmodium and Toxoplasma.” Authors:.Bushkin GG, Ratner DM, Cui J, Banerjee S, Duraisingh MT, Jennings CV, Dvorin JD, Gubbels MJ, Robertson SD, Steffen M, O’Keefe BR, Robbins PW, Samuelson J.

Pathology & Laboratory Medicine News Items

Announcements

• Bryan Belikoff, MD/PhD candidate has recently been placed on the Hematology Training Grant.
• Grants:
  • Marten Steffen’s, PhD recently awarded Grand Opportunity Grant (1RC2GM092602-01; multi-PI: Steffen, Kasif, Roberts) has been highlighted in an NIH news release. The goal of the grant, entitled “SciBay: A New Methodology for Scientific Collaboration and Gene Function Determination,” is to catalyze experimental validation of gene function for genes with no known function in bacterial genomes. This grant will implement the experimental validation model proposed by co-PI Rich Roberts, the recipient of the 1993 Nobel Prize in Physiology or Medicine for his discovery of introns.   We will form a consortium of experimental and computational biologists that would collaborate directly to test experimentally the predicted functions of high-priority genes of currently unknown function or specificity. This high profile initiative is our attempt to ameliorate a profound problem exacerbated by next generation sequencing methods.   If one were to sequence a newly discovered microbe today, the percentage of genes of unknown function would be very similar to that obtained a decade ago.   We anticipate that, in the near future, as the new methods become more widely used, and generate giga- and tera-bases of new sequence data, this problem will become quantitatively worse.   It is therefore imperative that we develop both new methods and opportunities for determining gene function.

Publications-ACCEPTED

• Marier Hernandez-Perez MD, one of our current residents, has a paper accepted for publication at The American Journal of Surgical Pathology Title:  “Distinctive Association of p16INK4a Over-expression with Penile Intraepithelial Neoplasia (PeIN)Depicting Warty and/or Basaloid Features: A study of 141 Cases Evaluating a New Nomenclature.”   Authors: Alcides Chaux, M.D.; Rolf Pfannl, M.D.; Belén Lloveras; María Alejo; Omar Clavero; Cecilia Lezcano; Nubia Muñoz; de Sanjosé Silvia, M.D., Ph.D.; Xavier Bosch; Marier Hernández-Pérez, M.D.; Elsa F Velazquez, M.D.; Antonio L Cubilla, M.D.

Pathology & Laboratory Medicine News Items

Announcements:

• Nancy Bucher Professorship. The Department is extraordinarily pleased to announce the Nancy L.R. Bucher Career Development Professorship Fund. The Board of Trustees of Boston University formally approved the professorship in October, 2009. The award was announced at the pathology research seminar by Richard Hotchkiss, M.D. on October 23, 2009. Dean Antman was in attendance for the announcement and seminar.The Department was able to raise money from multiple sources to fund this Professorship. The professorship is named for Dr. Bucher, a long time faculty member in the Department who has made significant scientific contributions to understanding of liver regeneration publishing dozens of articles in leading journals. Dr. Bucher is a fellow of the American Association for the Advancement of Science as well as the American Academy of Arts and Sciences. She has received the Distinguished Scientific Achievement Award from the American Liver Foundation.Funds from the Bucher Professorship will be used to recruit a junior faculty member and provide salary support during the initial phase of their career. The Bucher Professorship will be rolling and allow the ongoing recruitment of new faculty.
• Strategic Plan developed and posted. A committee was formed in the spring of 2009 to develop a strategic plan for the Department. The committee was chaired by Daniel Remick, M.D. and staffed by Debra Kiley. Other committee members included Chris Andry, Ph.D., Lija Joseph, M.D., Martin Kroll, M.D., Michael O’Brien, M.D., and Jacqueline Sharon, Ph.D. The committee worked diligently throughout the summer to prepare a strategic plan. The steps included preparing a Strengths, Weaknesses, Opportunities and Challenges review for Education, Anatomic Pathology, Laboratory Medicine and Research. The committee compared our Department to benchmark data available from the Association of Pathology Chairs and also did a comparison of the Department profile in 2004 and 2008. Input from the faculty was also solicited through direct conversations, internet surveys, and the development of an on-line discussion forum. Some of these investigative activities were successful, but the discussion forum was heavily utilized. The strategic plan has been completed, and it posted on the Department’s website here.
• Boston University has been awarded a grant from the Intersociety Council for Pathology Information to form a Pathology Interest Group. The funds from this grant will be used to promote activities to increase interest in a career in pathology among medical students. Dr. Lija Joseph needs to be thanked for her work in obtaining these funds. While the money goes to the Department, Dr. Joseph did all the work.
• From the Policy Committee: As policies are approved by the Chair they will be posted on the departmental website. The first two policies to be posted are: 1) The Professional Stipend Policy and 2) The Vacation/Professional Time-off Policy.
• Jackie Sharon’s pioneering research on recombinant polyclonal antibodies, which was patented and licensed by BU to the Danish company Symphogen A/S in 2001, was featured in the 2009 issue of the magazine Research at Boston University that was published in October. The story was part of an article about Technology Development at BU. As pointed out by the article, Symphogen is a rising star of biotech, employing 70 people in Copenhagen, who are developing recombinant human polyclonal antibodies against several infectious disease and cancer targets as well as human cells associated with certain immunologic diseases. The company’s most advanced product, currently in Phase 2 clinical trials, is a drug that would treat idiopathic thrombocytopenic purpura and hemolytic disease of the newborn, two immunologic diseases which involve uncommon susceptibility to bleeding.

Presentations:

• Madhu Jagannathan’s, PhD candidate abstract “Toll-like Receptor Cross Talk Specifically Regulates Cytokine Production by B cells from Chronic Inflammatory Disease Patients”   has been accepted for an oral presentation at the 3rd Annual MedImmune Research Abstract Competition in Gaithersburg, MD on Nov 14th 2009.
• Michael Roehrl, MD; PhD one of our new faculty members, has been invited to talk at the Association for Mass Spectrometry Applications to the Clinical Lab (MSACL), Conference Feb. 2010, San Diego, CA

Publications-ACCEPTED:

• Madhu Jagannathan, PhD candidate received news that her first author paper, “Toll-like Receptor Cross Talk Specifically Regulates Cytokine Production by B cells from Chronic Inflammatory Disease  Patients” has been accepted for publication in Journal of Immunology
  o Martin Steffen, PhD has had a paper accepted in PloS ONE: “A PREDICTIVE PHOSPHORYLATION SIGNATURE OF LUNG CANCER” authors; Wu, Cai, Rikova, Merberg, Kasif, Steffen
• Sandra Cerda, MD just had a paper accepted for publication in Pediatrics Journal. “Placental Inflammatory Response is Associated with Poor Neonatal Growth: A Preterm Birth Cohort Study”  Karen Mestan, M.D.1, Yunxian Yu, M.D., Ph.D.2, Nana Matoba, M.D.1, Sandra Cerda, M.D.3, Bethany Demmin, B.A.1, Colleen Pearson, B.A.4, Katherin Ortiz, B.A.4, Xiaobin Wang, M.D., M.P.H., Sc.D.2
• Michael Roehrl, MD; PhD one of our new faculty members, recently had his paper *. “Tissue proteomics reveals differential and compartment-specific roles for the homologs transgelin and transgelin-2 in lung adenocarcinoma and its stroma” Rho JH, Roehrl MHA,* Wang JY, accepted to Journal of Proteome Research 2009 (in press). *Corresponding authors.