November 2012

December 4th, 2012 in Uncategorized

Pathology & Laboratory Medicine News Items

 

Announcements:

  • Dr. Antonio de las Morenas gave the annual Stanley L. Robbins lecture to the New England Society of Pathologists on November 13th. This lecture is named in honor of Dr. Robbins, former Chair of Pathology and Laboratory Medicine at Boston University School of Medicine. Dr. de las Morenas’s  lecture “Challenges in the Diagnosis of Well Differentiated Thyroid Carcinoma” was presented to a standing room only group of pathologists.
  • Kurosawa Lab News:
    • An invited review was published from the Kurosawa Lab in Toxins, in a special issue entitled: Novel Properties of Well-Characterized Toxins.  First authorship is shared by Pathology graduate students Chad Mayer (MD,PhD candidate) and Caitlin Leibowitz (PhD candidate), who wrote most of the text and contributed equally.
  • Mayer, CL*, Leibowitz, CS*, Kurosawa S, Stearns-Kurosawa, DJ. Shiga Toxins and the Pathophysiology of Hemolytic Uremic Syndrome in Humans and Animals.  Toxins4(11), 1261-1287, 2012.  doi:10.3390/toxins4111261.  *Equal first authors
  • Dr. Stearns-Kurosawa was invited to give a presentation at the American Society of Nephrology in San Diego, October 30 – November 4, in a session dedicated to new treatments for atypical hemolytic uremic syndrome and Shiga toxin-related acute kidney injury.  Her presentation was entitled “Development and Treatment of HUS in Nonhuman Primates Induced by Toxins from Enterohemorrhagic E.coli.
  • Dr. Forum Raval has joined Barbara Nikolajczyk’s lab as a post-doctoral fellow. Forum did her PhD in Immunology with Dr. Eva Szomolanyi-Tsuda at UMass Medical School. She is joining BU as a recipient of a Hematology Training Program Award
  • Dr. Daniel Remick served on a panel of speakers at the 2012 Society of Leukocyte Biology workshop on grantsmanship October 28 – 30 in Maui, Hawaii
  • Dr. Carmen Sarita-Reyes was part of a panel that discussed “The use of AJCC Staging in Clinical Practice, Including the use of prognostic indicators, evidence based national guidelines used in treatment planning in breast cancer cases”. Presenters: Dr. Carmen D. Sarita-Reyes, Dr. Jane Mendez, and Dr. Moussa Sissoko. November 21st 2012, 670 Albany Street; Lobby Level #107/108.

 

Publications ACCEPTED:

  • Bouchard, Jacqueline; Beal, Dominic; Kim, Jiyoun; Vaickus, Louis; Remick, Daniel. CHEMOKINES MEDIATE ETHANOL-INDUCED EXACERBATIONS OF MURINE COCKROACH ALLERGEN ASTHMA Authors: To be published in Clinical and Experimental Immunology

 

Publications: PUBLISHED:

  • Wood DE, Lin H, Levy-Moonshine A, Swaminathan R, Chang YC, Anton BP, Osmani L, Steffen M, Kasif S, Salzberg SL. Thousands of missed genes found in bacterial genomes and their analysis with COMBREX Biology Direct. 2012 Oct 30;7(1):37

October 2012

November 15th, 2012 in Uncategorized

Pathology & Laboratory Medicine News Items

Announcements:

  • The Cancer Human Biobank Project at the NCI has funded a two year contract with the Department of Pathology and Laboratory Medicine at BMC worth up to $500,000-.  The collection of biospecimens in a pre-analytic variables study will bring the biospecimen archive research core (BARC) to the next level in state-of-the-art biospecimen collection, preservation and analysis.  This award is a culmination of departmental and hospital-wide investment in preparation for this project
  • Barbara Nikolajczyk, PhD has been invited to present her team’s work on “Immunometabolism” at
    • The Miami 2013 Winter Symposium: The Molecular Basis of Metabolism and Nutrition in February, 2013 as well as the following presentations:
    • American Association of Immunologists, Guest Symposium speaker, “B lymphocytes are master regulators of a pro-inflammatory T cell balance in obesity and glucose intolerance”, Honolulu Hawaii, 2013
    • University of Miami, Department of Immunology, Miami Florida, “Human B lymphocytes are master regulators of a pro-inflammatory T cell balance in type 2 diabetes”, 2013
    • Childrens Hospital Los Angeles, Childrens Center for Cancer and Blood Diseases, Los Angeles, CA, “Human B lymphocytes are master regulators of a pro-inflammatory T cell balance in type 2 diabetes,” 2013
  • 2nd Year Resident Manisha Mehta’s poster has been accepted by the AAOOP (American Association of Ophthalmic Oncologists and Pathologists) for their 2012 Annual meeting to be held in Chicago on Nov 9, 2012. “Immunological profile of 2 cases of conjunctival SCC from Africa”; Manisha Mehta, Stephen Christiansen, Jose Caro, Nora Laver
  • Congratulations to Dr. Huihong Xu as the Shattuck Hospital’s New Chief of Pathology
  • Jason Sutin, PhD student presented the poster “Simultaneous Optical and Electrical Measurement of Neurovascular Coupling in Awake Rats” at Neuroscience 2012 on October 17th in New Orleans
  • Dr. Sandra Cerda received a Poster Citation for her poster presented October 21st at the ACG (American College of Gastroenterology) 2012 Annual Scientific Meeting in Las Vegas, Nevada; “Significance of granulomatous inflammation found on endoscopic biopsies or surgical resections on the severity and prognosis of Crohn’s Disease.” Kanneganti M, Dehghani B, Steinberg J, Cerda S, Rybin D, Weinberg J, Farraye FA.
  • PhD Student Zach Hunter’s abstract was selected for an oral presentation at the BU Genomic Science Institute symposium this past Monday (10/22). “Copy Number and Small Variant Analysis from Whole Genome Sequencing of 30 Patients with Waldenstrom’s Macroglobulinemia” Link to the BU GSI website
Pumpkin2 Bravo, Spooktacular to Lab Medicine for being one of the tip three Pumpkin Decorating Contest winners with “The Mad Scientist” pumpkin! Pumpkin1

 

Publications: PUBLISHED:

  • Snyder-Cappione, JE and Nikolajczyk, BS. When Diet and Exercise Aren’t Enough, Think Immunomodulation. 2012. Molecular Aspects of Medicine. (In Press).
  • Kanneganti M, Dehghani B, Steinberg J, Cerda S, Rybin D, Weinberg J, Farraye FA. Significance of granulomatous inflammation found on endoscopic biopsies or surgical resections on the severity and prognosis of Crohn’s Disease.  American  Journal of Gastroenterology 2012;107:S633
  • Treon, S. P., Tripsas, C., Hanzis, C., Ioakimidis, L., Patterson, C. J., Manning, R. J., Sheehy, P., Turnbull B, Hunter ZR. Familial Disease Predisposition Impacts Treatment Outcome in Patients With Waldenström Macroglobulinemia. Clinical lymphoma, myeloma & leukemia. doi:10.1016/j.clml.2012.08.006

September 2012

October 9th, 2012 in Uncategorized

Pathology & Laboratory Medicine News Items

Announcements:

  • Zachary Hunter, PhD Candidate, spoke at the 7th International www.wmworkshop.org Workshop on Waldenstrom’s Macroglobulinemia in Newport, Rhode Island, August 23-26, 2012 this included:
    • Mutational Landscape of WM  Revealed  Through Whole Genome Sequencing
    • MYD88 L265P as a response marker in  Waldenstrom’s Macroglobulinemia
  • Zach followed up his presentation with in a workshop summary session for patients following: Revelation of MYD88 L265P as a Novel Mutation in WM
  • Barbara Nikolajczyk, PhD has been awarded a new grant; “The Role of Lymphocytes in Diet-Induced Metabolic Disease,” NIH/NIDDK R56, Funding Period – 9/1/12 – 8/31/13
  • Barbara Nikolajczyk, PhD made presentations at:
    • The Obesity Society Pre-conference Workshop on Adipocyte Metabolism “Lymphocytes in Immunometabolism” San Antonio, Texas, September 20-21, 2012
    • The Obesity Society Plenary Oral Presentation, B lymphocytes are master regulators of a pro-inflammatory T cell balance in obesity and glucose intolerance, San Antonio, Texas, September 20-21, 2012
  • The Nikolajczyk Lab has a new addition: Anna Blekina has joined the lab as a post-doctoral fellow
  • Missy Cohen in Laboratory Medicine was a presenter on a panel at the American Association of Tissue Banks (AATB). She discussed our method of storing and managing tissue through Transfusion Services in a similar manner as managing blood as opposed to managing and storing tissues in the O.R. The purpose of the panel as a whole was to convince tissue procurement and processing groups of using an international method of labeling tissue known as ISBT128 labeling. This method of labeling has been a requirement of the AABB (American Association of Blood Banks) for several years now with great success of being able to uniquely identify every unit of blood that has been collected on an international level and allowing for improved distribution of blood across borders which, in turn, allows blood to be delivered to places that need it most.
  • Next month Missy Cohen will be visiting with the Vice President of Tissue Services at the New England Organ Banks (NEOB), Diana Buck, to tour their facility and see where the tissues and organs that we use come from. While there, Missy will be sharing information with Diana and her staff about ISBT128 labeling and how their tissue improves the lives of our patients
  • Dr. Lija Joseph presented:
    • A poster at the College of American Pathologists Annual Meeting, San Diego California, September 9-12, 2012; “Optimizing Hematopathology Services in a Community Hospital Setting” (Poster No. 51) Joseph L; Ibrahim, S; Anamur M,  Gryzenia, P , 2012) Abstracts and Case Studies From the College of American Pathologists 2012 Annual Meeting (CAP ’12). Archives of Pathology & Laboratory Medicine: September 2012, Vol. 136, No. 9, pp. 1005-1162
    • A second poster presented at the College of American Pathologists Annual Meeting, San Diego California, September 9-12, 2012. “Unusual Findings in a Knee Joint Treated With Hyaluronidase and Steroids” (Poster No. 70) Joseph L, Wu, H 2012) Abstracts and Case Studies From the College of American Pathologists 2012 Annual Meeting (CAP ’12). Archives of Pathology & Laboratory Medicine: September 2012, Vol. 136, No. 9, pp. 1005-1162.
  • Dr. Ivana Delalle will represent the Department of Pathology on a regular basis at a recently started conference series “Clinical Neuroscience Grand Rounds”

 

Publications Accepted:

  • Sudha Natarajan, Daniel G. Remick. ELISA Rescue Protocol: Recovery of Sample Concentrations from an Assay with an Unsuccessful Standard Curve. Methods
  • Andrea Havasi, Joseph A. Haegele, Jonathan M. Gall, Sherry Blackmon, Takaharu Ichimura, Ramon G. Bonegio, Maria V. Panchenko.  Histone Acetyl Transferase (HAT) HBO1 and JADE1 in Epithelial Cell Regeneration” Accepted for publication in the American Journal of Pathology
  • Foy RL, Chitalia VC, Panchenko MV, Zeng L, Lopez D, Lee JW, Rana SV, Boletta A, Qian F, Tsiokas L, Piontek K, Germino GG, Zhou MI, Cohen HT: Polycystin-1 regulates the stability and ubiquitination of transcription factor Jade-1. Human Molecular Genetics 2012 (in press)
  • Earl Gillespie a, Susan E. Leeman a, Luisa A. Watts d, Jennifer A. Coukos c, Michael J. O’Brien d, Sandra R. Cerda d, Francis A. Farraye c, Arthur F. Stucchi b. Plasminogen Activator Inhibitor-1 is Increased in Colonic Epithelial Cells from Patients with Colitis-Associated Cancer☆. Journal of Crohn’s and Colitis
  • Tolga Sursal1*, Deborah J Stearns-Kurosawa2*, Kiyoshi Itagaki1, Sun-Young Oh2**, Shiqin Sun1**, Shinichiro Kurosawa2, Carl J Hauser1.  Plasma Bacterial and Mitochondrial DNA Distinguish Bacterial Sepsis from Sterile SIRS and Quantify Inflammatory Tissue Injury in Nonhuman Primates. SHOCK in press

 

Publications: PUBLISHED

  • Steven P. Treon, M.D., Ph.D., Lian Xu, M.S., Guang Yang, Ph.D., Yangsheng Zhou, M.D., Ph.D., Xia Liu, M.D., Yang Cao, M.D., Patricia Sheehy, N.P., Robert J. Manning, B.S., Christopher J. Patterson, M.A., Christina Tripsas, M.A., Luca Arcaini, M.D., Geraldine S. Pinkus, M.D., Scott J. Rodig, M.D., Ph.D., Aliyah R. Sohani, M.D., Nancy Lee Harris, M.D., ason M. Laramie, Ph.D., Donald A. Skifter, Ph.D., Stephen E. Lincoln, Ph.D., and Zachary R. Hunter, M.A. MYD88 L265P Somatic Mutation in Waldenstrom’s Macroglobulinemia. The New England Journal of Medicine, med 367;9 nejm.826 org august 30, 2012
  • Joseph L (Chapter 2, pages 31-44) Non-neoplastic disorders of platelets: in Nonneoplastic hematopathology and infections, Editors Cualing, Bhargava ans Sandin; Wiley-Blackwell 2012.

August 2012

September 12th, 2012 in Uncategorized

Pathology & Laboratory Medicine News Items

Announcements

  • On August 9th at the 31st Annual Sunquest User Group Meeting, “People at the Heart of Healthcare”, in Scottsdale Arizona, Boston Medical Center received an award. As Program Chair for the SUG 2012 Meeting, Silvia MacMurdo was there to proudly receive the award. Below is what was read during the presentation. The award will reside at 670 Albany St in the 7th Floor Lab Administration Office.
    • Excellence in Workflow Standardization
    • Boston Medical Center
      Sunquest would like to recognize Boston Medical Center for Excellence in Workflow Standardization. Boston Award photo.2012 (6)Medical Center moved into a new state of the art laboratory that utilizes a streamlined automated workflow.  The commitment they had to this project was truly incredible. They worked tirelessly to ensure that the facility would be ready with the latest research, state-of-the-art technology and exceptional clinical capabilities.
  • Additionally, innovative workflows enable their staff to address the complex range of medical, social, economic and emotional factors that affects the health of our most vulnerable patients. They set the bar for what labs can be, and proved that laboratory has a great responsibility to be excellent for our patients.
  • Recent graduates Drs. Hao Wu, Dehua Wang, Stephen Hammond, Kate Downey passed their AP/CP board examinations. Dr. Marier Hernandez-Perez passed her AP exam. They are well launched into their subspecialty fellowship training at BMC (Dr. Wu), Indiana; (Dr. Wang), New York; (Drs. Hammond, Downey), and Houston (Dr. Hernandez-Perez).
  • Congratulations on passing the Qualifying Exams!
    • Parul Agnihotri
  • Welcome New Students:
    • Sun Young Jang, MA student joining us from UMass/Amherst
    • Erica Langley, PhD candidate coming from BU
    • Benjamin Lee, a Masters candidate, comes in from the University of Northern Colorado
    • Melody Lun is an MD/PhD student joining our department
    • Liz Moses is joining the ITP/Pathology PhD Program coming to us from Colorado State University
    • Jacqueline Sikora is coming into Pathology PhD Program from BU’s CMB Program
    • Mark Wojnarowicz, a PhD candidate also arrives from our very own Boston University

 

Publications Accepted:

  • Bryan G. Belikoff, Louis J. Vaickus, Michail Sitkovsky, and Daniel G. Remick. A2B Adenosine Receptor Expression by Myeloid Cells is Pro-Inflammatory in Murine Allergic-Airway Inflammation1 Journal of Immunology
  • Marcin F. Osuchowski, Florin Craciun, Katrin Weixelbaumer, Elizabeth R. Duffy and Daniel G. Remick. SEPSIS CHRONICALLY IN MARS: SYSTEMIC CYTOKINE RESPONSES ARE ALWAYS MIXED REGARDLESS OF THE OUTCOME, MAGNITUDE OR PHASE OF SEPSIS; Journal of Immunology

 

Publications: PUBLISHED

  • Nikolajczyk BS, Jagannathan-Bogdan M, Denis GV. The outliers become a stampede as immunometabolism reaches a tipping point. Immunology Review 2012 Sep;249 (1):253-75. doi: 10.1111/j.1600-065X.2012.01142.x.PMID: 22889227 [PubMed - in process]
  • Earl Gillespie a, Susan E. Leeman a, Luisa A. Watts d, Jennifer A. Coukos c, Michael J. O’Brien d, Sandra R. Cerda d,Francis A. Farraye c, Arthur F. Stucchi b. Plasminogen Activator Inhibitor-1 is Increased in Colonic Epithelial Cells from Patients with Colitis-Associated Cancer. PAI-1 and Colitis-Associated Cancer; 2 August 2012
  • Natarajan S, Kim J, Bouchard J, Cruikshank W, Remick DG: Pulmonary Endotoxin Tolerance Protects against Cockroach Allergen-Induced Asthma-Like Inflammation in a Mouse Model, Int Arch Allergy Immunol 2012, 158:120-130, PMID: 22269653
  • Winfield RD, Delano MJ, Cuenca AG, Cendan JC, Lottenberg L, Efron PA, Maier RV, Remick DG, Moldawer LL, Cuschieri J: Obese Patients Show a Depressed Cytokine Profile Following Severe Blunt Injury, Shock 2012, PMID: 22266966
  • Bouchard JC, Kim J, Beal DR, Vaickus LJ, Craciun FL, Remick DG: Acute oral ethanol exposure triggers asthma in cockroach allergen-sensitized mice, American Journal of  Pathology 2012, 181:845-857, PMID: 22796441
  • Vaickus LJ, Bouchard J, Kim J, Natarajan S, Remick DG: Cockroach allergens induce biphasic asthma-like pulmonary inflammation in outbred mice, The Journal of Asthma 2012, 49:510-521, PMID: 22540923

July 2012

July 31st, 2012 in Uncategorized

Pathology & Laboratory Medicine News Items

Announcements:

  • Congratulations to Rituparna Moitra, PhD, who successfully defended her thesis

    RituDefense.Dan  Ritu

    Newly Defended Dr. Rituparna Moitra with her mentor and Department Chair, Daniel Remick, MD

    “HETEROGENEITY IN SURVIVAL TO SEPSIS: INHIBITORY IMMUNOGLOBULIN “G” IN PLASMA BLOCKS MACROPHAGE MEDIATED KILLING OF ENTERIC BACTERIA” on Wednesday, July 25th

Kao.Delalle.Defense.2012.IMG_3414

Newly Defended Dr. Patricia Kao with her mentor, Ivana Delalle, MD; PhD

  • Congratulations to Patricia Kao, PhD, who successfully defended her thesis “IDENTIFYING REGULATORS OF BRAINRESERVE AND NEUROPATHOLOGICAL CHANGES IN COGNITIVE AND MOOD DISORDERS” on Wednesday, July 25th
  • David Sherr, PhD was awarded a 2 year grant from the Mary Kay Foundation to study the role of the AhR in breast cancer.
  • Dr. Sherr also got a Coulter Award to develop AhR-targeted therapeutics
  • Jessica Allen, 2nd year PhD Candidate, going into Caroline Genco’s Lab for her thesis work has been awarded a “Cross-disciplinary Training in Nanotechnology for Cancer” (XTNC) Fellowship for the period 9/1/12-8/31/13
  • Panchenko Lab:
    • Two talented young researchers, Joseph Haegele and Sherry Blackmon, moved on after completing a year of productive research in the Panchenko Lab followed by glorious acceptances into top tier competitive graduate schools. Joe is currently enrolled in PhD program at Cornell University, while Sherry is pursuing DVM/PhD degree at the School of Veterinary Medicine at Mississippi State University.
    • New people: A recent graduate from Harvard University, Joseph Mandelbaum, started working in the lab in July. His goal is to publish papers and move on to a PhD Program. Alice Lee is a Boston University sophomore. She won a $4000 UROP (Undergraduate Research Opportunities Program) Award to receive training during Summer 2012 in Dr. Panchenko’s lab.
  • Kurosawa Lab: Please welcome summer students in the Kurosawa Lab:
    • Connor Jacobson is a high school student from New York in the lab via the BU RISE Program.   Connor is testing different reagents expected to minimize endoplasmic reticulum stress responses in kidney epithelial cells.  He will give a poster on his project on August 10th.
    • Jonathan Greenbaum is a Boston University undergraduate student participating in the BU UROP Program.  Jonathan’s project is testing the ability of IL-15 to minimize the cellular damage elicited by toxins from enterohemorrhagic E.coli.   He will present his results in a poster session at the end of July.
    • Ben Lee is an incoming BU Master’s student in the Pathology Department. He has experience with immunoglobulin cloning from vaccinated bats (yes, bats).  Ben is working on two projects: identifying mechanisms for the protective properties of an anti-Shiga toxin peptide – and- development of methods for isolating intestinal epithelial cells.
  • Remick Lab:
    • Rui Soares, a junior from Boston College, is working in the Remick lab this summer as part of the Summer Undergraduate Research Program (SURP) at Boston University. Rui’s project is to determine whether mitochondrial Damage Associated Molecular Patterns (MTDs) contribute to mortality from sepsis. Rui is working under the guidance of Evan L. Chiswick, a PhD Candidate in the Remick Lab
    • Sai Kottapalli is a Master’s Student in the Medical Sciences program at Boston University School of Medicine. He is currently working on his thesis investigating the role of immune supressor cells in cockroach allergen induced asthma.
    • Chunzi Zhang comes from Penn State University. Chunzi originally comes from China and has finished her junior year as a human nutrition major.  She is working on “An anti-oxidant, resveratrol treatment of asthma-like inflammation induced by co-exposure to air pollutants and allergens.”  Chunzi started working under the mentorship of Dr. Jiyoun “John” Kim on May 29 and will stay with us until August 17.

 

Publications: PUBLISHED

  • Kao PF, Banigan MG, Vanderburg CR, McKee AC, Polgar PR, Seshadri S, Delalle I.; “Increased Expression of TrkB and Capzb2 Accompanies Preserved Cognitive Status in Early Alzheimer Disease Pathology.” Journal of Neuropathology and Exp Neurology 2012 Jul;71(7):654-64.

June 2012

July 2nd, 2012 in Uncategorized

Pathology & Laboratory Medicine News Items

Announcements:

  • Castle Graduation Celebration 2012
Castle2012.Kristina.Chris.MaryJo.P1000302[1]
New PhD Graduate Dr. Kristina Perry, Committee Member and Co-Director Graduate Program, Dr. Chris Andry and Kristina’s Committee Chair, Dr. Mary-Jo Murnane
Castle-6 New PhDs: Dr. Jacqueline Bouchard, Dr. Madhu Bogdan, Dr. Kristina Perry and Dr. Srimathi Srinivasan
Castle-8 Graduate Dr. Srimathi Srinivasan and her mentor Dr. Nader Rahimi
  • Congratulations on passing the Qualifying Exams!
    • Caitlin Leibowitz
    • Zachary Hunter
    • Chad Mayer
    • Nicole Stauffer
    • Martin Steinbuck
    • Thank you to all faculty members who assisted with the qualifying exams, with a SPECIAL Thank You Dr. Bohdana Burke
  • Barb Nikolajczyk presented her team’s work at the American Diabetes Association Annual Meeting June 2012.  The title of the work was “B Lymphocytes are Master Regulators of a Pro-inflammatory T Cell Balance in Obesity and Glucose Intolerance”. This work has also been selected as a plenary oral presentation for The Obesity Society Annual meeting in Sept. 2012 in San Antonio TX. Dr. Nikolajczyk has also been invited as a panel member at an Obesity Society Annual Meeting Pre-conference Workshop on Adipocyte Metabolism
  • Barb Nikolajczyk also presented “B lymphocytes are master regulators of a pro-inflammatory T cell balance in obesity and glucose intolerance ” as an invited speaker at the Univ. of Pennsylvania Immmunology seminar series in June, 2012
  • David Stepien, MD/PhD candidate in the Remick Lab was invited to give an oral presentation at the 35th Annual Conference on Shock entitled: “Traumatic Brain Injury Enhances the Pulmonary Immune Response to Pseudomonas aeruginosa Pneumonia” on June 10th in Miami Beach, FL. David also received a Travel Award from the Shock Society to attend the conference
  • Welcome Summer Students in the Kurosawa Lab:
    • Jonathan Greenbaum, a BU undergrad from the UROP program
    • Conor Johnson, a high school student from the BU RISE program
    • Ben Lee, a Pathology Master’s student
    • Erin Kelley, an undergrad from Bates College in Maine
  • Caitlin Miller, 2nd year PhD candidate has recently been accepted into the ITP Program. She will be doing her thesis work in Rahm Gumuluru’s Lab

 

Publications: ACCEPTED

  • Anthony Makkinje, Pierre Vanden Borre, Richard I. Near, Prayag S. Patel and Adam Lerner. “Breast cancer anti-estrogen resistance 3 (BCAR3) augments binding of the c-Src SH3domain to Crk-associated substrate (p130Cas)” The Journal of Biological Chemistry
  • Girnius S, Dember L and Lerner A. “Diabetes insipidus as presenting manifestation of Waldenstrom’s macroglobulinemia” Journal of Hematology

May 2012

June 1st, 2012 in Uncategorized

Pathology & Laboratory Medicine News Items

Announcements:

  • Our own Chris Andry, MPhil, PhD and his colleague in Cancer Care Services, Robyn Souza, RN were recognized by the Otolaryngology Department for their contributions to the Head and Neck Cancer Service at BMC. The award is named after Elaine Ullian, the former CEO of Boston Medical Center.
  • Dr. Barbara Slack is very happy to announce this year’s Russek Award recipients in the Department of Pathology:
    • First Prize- Jacqueline Bouchard, PhD (Advisor: Daniel Remick)
    • Second Prize- Patricia Kao, PhD Candidate (Advisor: Ivana Delalle)
    • Honorable Mention- Srimathi Srinivasan, PhD (Advisor: Nader Rahimi)
    • Congratulations to the awardees, and thanks to everyone who submitted abstracts for the poster session. This year’s Russek Day took place on May 11th in the Hiebert Lounge (L building, 14th floor) with many faculty and students attending!
  • Kurosawa Lab Graduate students Caitlin Leibowitz, PhD Candidate and Chad Mayer, MD/PhD Candidate contributed data to two abstracts accepted at international conferences:
    • The 7th Congress of the International Federation of Shock Societies and 35th Annual Conference on Shock, The Shock Society; Miami, Florida, June 9-13, 2012; DJ Stearns-Kurosawa, Chad Mayer, Caitlin Leibowitz, Shinichiro Kurosawa. “EHEC bacterial toxins-1 and-2 are synergistic in non-human primates”
    • The 58th Scientific and Standardization Committee of the International Society on Thrombosis and Haemostasis; Liverpool, England, United Kingdom, June 27-30, 2012. D. Stearns-Kurosawa, C Leibowitz, C Mayer, S Kurosawa. “Developing Animal Models of Hemolytic Uremic Syndrome”
  • The Kurosawa Lab collaboration with Dr. Heather Hardway at BU Department of Mathematics and Statistics resulted in two abstracts accepted at international conferences:
    • The 7th Congress of the International Federation of Shock Societies and 35th Annual Conference on Shock, The Shock Society; Miami, Florida, June 9-13, 2012. Heather Hardway, DJ Stearns-Kurosawa, Shinichiro Kurosawa; “Monitoring Host Improvement or Decline Over Time Using Grouped Data Sets”
    • The 58th Scientific and Standardization Committee of the International Society on Thrombosis and Haemostasis; Liverpool, England, United Kingdom, June 27-30, 2012. H Hardway, D Stearns-Kurosawa, S Kurosawa.  “Modeling Physiological and Cytokine Data to Predict Outcome”
  • Chad Mayer, MD/PhD Candidate in the Kurosawa Lab received a training grant from the Cardiovascular Institute on the BUSM Campus
  • Dr. Susan Winandy served on  the Cellular and Molecular Biology-B NIH study section in May
  • Alex Gallant, 3rd year medical student going into Pathology has received the American Society for Clinical Pathology Medical Student Achievement Award for Academic Excellence and Achievement in Pathology. There are only 10 medical students in the country who receive this award each year. Included in the award is an Amazon Kindle Fire and the second edition of the Handbook of Clinical Pathology
  • Nancy S. Miller, MD presented “Prudent Culture Practice & Challenges:  When to give an inch and when to go the mile”, as an invited speaker at the 28th Annual Meeting of the Northeast Association for Clinical Microbiology and Infectious Disease (NACMID), May 21-23, in Boxborough, Massachusetts
  • The Cadaver Biopsy Project members presented two posters at the John McCahan Medical Education Day, on May 23 at Boston University. Congratulations to medical students Hillary Johnston Cox, Anna Eisenstein, Lev Vaisman, Alexander Gallan and mentors Dr. Carl O’Hara and Dr. Lija Joseph
  • Graduation 2012
Graduation2012.Photo3.Jackie.Dan.Graduation Graduation2012.Photo2.Madhu.Supraja.Kristina.IMAG0200 Graduation2012.Photo4.Jackie.Madhu.Celebrating.0002259-R1-017-7 Graduation2012.Photo1.Sri.Madhu.Jackie.IMAG0203
Dr. Daniel Remick, Department Chair and his graduating Lab Member Dr. Jacqueline Bouchard New PhDs: Dr. Madhu Bogdan, Dr. Supraja Narasimhan and Dr. Kristina Perry Dr. Jacqueline Bouchard and Dr. Madhu Bogdan celebrating graduation! New PhDs: Dr. Srimathi Srinivasan, Dr. Madhu Bogdan and Dr. Jacqueline Bouchard

 

Publications: PUBLISHED

  • Dr. Lija Joseph has a chapter (Non neoplastic disorders of platelets) that she has authored just published by Wiley in Non-neoplastic hematopathology and infections, . The chapter also acknowledges one of the members of our hematology lab at BMC, Kathy White.

 

Publications: ACCEPTED

  • Kao PF, Banigan MG, Vanderburg CR, McKee AC, Polgar PR, Seshadri S, Delalle I: “Increased Expression of TrkB and Capzb2 Accompanies Preserved Cognitive Status in Early Alzheimer’s Disease Pathology” Journal of Neuropathology and Experimental Neurology
  • Ghosh CC, Mukherjee A, David S, Stearns-Kurosawa D, Kurosawa S, Parikh SM.  “Impaired Function of the Tie-2 Receptor Contributes to Vascular Leakage and Lethality in Anthrax” Proc National Academy of Science USA, in press 2012
  • Bouchard, J.C, Kim, J., Beal, D.R., Vaickus, L.J., Craciun, F.L. and Remick, D.G. “Acute Oral Ethanol Exposure Triggers Asthma In Cockroach-Allergen Sensitized Mice” in press, American  Journal of Pathology

April 2012

May 2nd, 2012 in Uncategorized

Pathology & Laboratory Medicine News Items

 

Announcements:

  • Daniel Remick, MD, has been elected as the Treasurer of the Faculty Practice Foundation of Boston Medical Center
  • Dr. Daniel Remick is pleased to report that Dr. Carmen Sarita-Reyes, co-director of the Dental School pathology course, has been appointed to the Joint Commission on National Dental Examinations (JCNDE) National Microbiology-Pathology Test Construction Committee for 2013. This appointment will allow the department of pathology to provide direct input into the formulation of test questions and will ensure that our Dental students receive instruction tailored to their specific needs. As best as we can determine, this is the first time a Boston University pathologist has been appointed to this national body.
  • Congratulations to Jacqueline Bouchard, PhD, who successfully defended her thesis “Immunological Mechanisms of Alcohol-Exacerbated Asthma” on Wednesday, April 4th
  • Zach Hunter, PhD Candidate presented his work at the Dana-Farber Hematologic Neoplasia & Immunologic Therapies Seminar Series; “Somatic Variants Revealed by Whole Genome Sequencing in Waldenstrom’s Macroglobulinemia” on Wednesday, April 4th
  • Zach Hunter, PhD Candidate also presented a poster at the American Society of Clinical Oncology in Chicago on June 4th, and he is its first author; “Use of Whole Genome Sequencing to Identify Highly Recurrent Somatic Mutations in Waldenström’s Macroglobulinemia” Zachary R Hunter, Lian Xu, Guang Yang, Yangsheng Zhou, Xia Liu, Yang Cao, Christina Tripsas, Robert J Manning, Christopher J Patterson, Patricia S Sheehy, Steven P. Treon
  • Joann Crain, Lab Medicine’s Point of Care Specialist, presented at the CLMA (Clinical Laboratory Management Association) Northeast Region Conference on April 10 in Boxboro MA on “Project Trust- An Overview of a Rapid HIV Testing Program”
  • Parul Agnihotri, PhD Candidate in the Winandy Lab will present an abstract entitled “Role of Ikaros in Foxo1-driven Gene Expression in CD4 T Cells” at the International Graduate Student Immunology Conference 2012 at Harvard University on April 27-28 2012
  • A poster by Resident Manisha Mehta, MD has been nominated for the “Member-in-training’ Award (MIT Award ) at the ARVO Conference (Association for Research in Vision and Ophthalmology) on May 8th, 2012 at Fort Lauderdale, Florida. Poster details: “PDCL3 Regulates Endothelial Cell Proliferation And Angiogenesis Through The Generation Of Functional VEGFR-2;” Manisha Mehta, Srimathi Srinivasan, Rosana D Meyer, Ricardo Lugo, Vipul Chitalia, Nora Laver, Nader Rahimi
  • April 30-May 4 is Lab Week; Happy First Anniversary in your new location Lab Medicine!!!

 

Publications: PUBLISHED

  • Fengxiu Ouyang, Margaret Parker, Sandra Cerda, Colleen Pearson, Lingling Fu, Matthew W. Gillman, Barry Zuckerman and Xiaobin Wang; “Placental Weight Mediates the Effects of Prenatal Factors on Fetal Growth: the Extent Differs by Preterm Status” Obesity April 2012
  • Marie E McDonnell, Lisa M Ganley-Leal, Ankeeta Mehta, Sherman J Bigornia, Melanie Mott, Qasim Rehman, Melissa G Farb, Donald T Hess, Lija Joseph, Noyan Gokce, Caroline M Apovian; “B Lymphocytes in Human Subcutaneous Adipose Crown-Like Structures” Obesity (impact factor: 3.37). 03/2012; DOI: 10.1038/oby.2012.54
  • Tan JN, Burke PA, Agarwal SK, Mantilla-Rey N, Quillen K; “A Massive Transfusion Protocol Incorporating a Higher FFP/RBC Ratio Is Associated With Decreased Use of Recombinant Activated Factor VII in Trauma Patients.” American Journal of Clinical Pathology 2012 Apr;137(4):566-71. PubMed PMID: 22431532.

 

Publications: ACCEPTED

  • Barbara S. Nikolajczyk, Madhumita Jagannathan-Bogdan and Gerald V. Denis. “The Outliers become a Stampede as Immunometabolism Reaches a Tipping Point” Immunological Reviews 2012
  • Nancy S. Miller, Belinda Yen-Lieberman, Melinda D. Poulter, Yi-Wei Tang, and Paul A. Granato; “Comparative Clinical Evaluation of the IsoAmp® HSV Assay with ELVIS® HSV Culture/ID/typing Test System for the Detection of Herpes Simplex Virus in Genital and Oral Lesions” Journal of Clinical Virology
  • Josenia N.M. Tan, Martin H. Kroll, Carl J. O’Hara, Peter C. Everett, Evrim Erdogan; “Gamma Heavy Chain Disease in a Patient with Underlying Lymphoplasmacytic Lymphoma of the Thyroid; Report of a Case and Comparison with Other Reported Cases with Thyroid Involvement” Clinica Chimica Acta

 

 

 

 

 

March 2012

April 4th, 2012 in Uncategorized

Pathology & Laboratory Medicine News Items

 

Announcements:

  • The Nikolajczyk Lab’s work, “B Lymphocytes are Master Regulators of a Pro-inflammatory T Cell Balance in Obesity and Glucose Intolerance” was done in collaboration with the Denis Lab and has been selected for:
    • An oral presentation at the American Association of Immunologists Annual Meeting in Boston inMay. Anna Belkina will be presenting.
    • An oral presentation at the American Diabetes Association Annual Meeting in Philadelphia in June. Dr.Barbara Nikolajczyk will be presenting.
  • Dr. Daniel Remick presented the annual John F. Sander and Nancy K. Dunkel Lecture at Michigan State University, “The Inflammatory Response in Sepsis” on March 1st
  • MSU Students Listening to Dr. Remick’s Lecture
    MSU Students Listening to Dr. Remick’s Lecture

     

  • The Faculty Practice Plan has been re-organized with a new board of directors. Dr. Remick was elected to a 2year term to serve on the Board of Directors. He was also elected to the finance committee of the Faculty Practice Plan and was appointed to the CARTS group to negotiate with Boston Medical Center for purchasedphysician services. CARTS is Clinical Administrative Research Teaching and Strategic components of the physician services provided to BMC
  • Connors Lab members, Michael Greene, PhD candidate, Clarissa Koch, PhD candidate, and Dr. Lawreen Connors will be attending and presenting at the XIIIth International Symposium on Amyloidosis “From misfolded proteins to well-designed treatment” from May 6-10, 2012 at University Medical Center in Groningen, The Netherlands.
  • Clarissa Koch, PhD candidate will be presenting her poster, “Cardiotoxicity of pre-fibrillar transthyretin oligomers and attenuation by doxycycline” at the 13th International Symposium on Amyloidosis conference in Groningen in May 2012
  • Also Dr. Connors is so proud to tell you that Michael and Clarissa been granted Travel Awards from The Amyloidosis Foundation. Bravo Mike & Clarissa!
  • Dr. Lawreen Connors will be giving an oral presentation entitled “Senile Systemic Amyloidosis: a large cohort study detailing clinical features, laboratory results and survival” at the symposium in Plenary Session 8: Biology, clinics and prognosis in ATTR amyloidosis. This research was done in collaboration with the Denis Lab
  • Dr. Daniel Remick chaired an NIH special emphasis panel to review a Trauma Center grant. He also served on a total of 5 NIH study sections between December 2011 and March, 2012
  • Dr. Carmen Sarita-Reyes was a Program Chair for the Program Chairs Workshops presented at the Society for Pediatric Pathology 2012, Annual Meeting Program Chairs Spring Meeting in Vancouver, BC, Canada March 17-18, 2012
  • Congratulations are in Order!!!
    • Srimathi Srinivasan, PhD, successfully defended her thesis “MOLECULAR REGULATION OF VEGFR-2 EXPRESSION AND ACTIVATION IN ENDOTHELIAL CELLS” on Thursday, March 22nd
    • Edward Hartsough, PhD, successfully defended his thesis “Molecular Regulation of VEGFR-2 Function and Expression through Post-Translational Modifications” on Monday, March 26th
    • Kristina Perry, PhD, successfully defended her thesis “COPY NUMBER ABERRATIONS AND INTEGRATION OF GENOMIC ARRAY DATA IN PREINVASIVE BREAST CANCER” on Monday, March 26th
  • Dr. Carmen Sarita-Reyes was a panel member at The Office of Diversity of Multicultural Affairs, Latino at BUMC – A Conversation. The goal of this activity was to have a candid dialogue on the challenges and successes of Latinos at BUMC. The anticipation was that this exchange would greatly benefit students, residents, and faculty following the footsteps of our distinguished panelists. Individuals from all ethnicities and cultures were strongly encouraged to attend. The panel discussion was moderated by Assistant Dean Dr. Samantha Kaplan. Panelists included: Carlos Kase, MD, Professor and Chair of Neurology; Jane Mendez, MD, Associate Professor of Surgery; Gerardo Rodriguez, MD, Assistant Professor of Anesthesiology and Carmen D. Sarita-Reyes, MD, Assistant Professor of Pathology and Laboratory Medicine
  • Nancy S. Miller, MD has been invited to be a featured speaker at the “Culture-Independent Diagnostics Forum: Charting a Path for Public Health” to be held at the CDC in Atlanta, April 2012. The forum is being organized by the U.S. Centers for Disease Control and Prevention (CDC), the Association of Public Health Laboratories (APHL), and the Council of State and Territorial Epidemiologists (CSTE), to address potentially serious emerging issues in the area of infectious disease surveillance caused by the use of culture independent methods in clinical diagnostic laboratories

 

Publications: PUBLISHED

  • BUSM authors (Ivana Delalle, MD, PhD and Patricia Kao, PhD candidate, Delalle Lab) contributed in the human brains analysis in this study that involved both mouse model and human tissue: For the first time in human post-mortem brain samples of patients at different stages of Alzheimer’s disease (AD), histone deacetylase (HDAC) 2 levels are shown to be elevated, suggesting that a epigenetic blockade of cognitive functions documented in mouse models of AD might be at play in the human brains inflicted by AD. This increase of HDAC2 leads to reduced histone acetylation of genes important for learning and memory, which show a concomitant decrease in expression resulting in impaired cognitive functioning. Link

 

Publications: ACCEPTED

  • Nader Rahimi, Kobra Rezazadeh, John E. Mahoney, Edward Hartsough, Rosana D Meyer. Identification of IGPR-1 as a novel adhesion molecule involved in angiogenesis. Molecular Biology of the Cell, 2012
  • Jin L, Roehrl MHA, Xiao L, He X, Li H, Ge L, Shi B. Crystallization and preliminary crystallographic study of a trypsin-resistant catalytic domain of human calcineurin. Acta Crystallographica F, 2012
  • Jonathan S. Kingsbury, Thomas M. Laue, Susan F. Chase, and Lawreen H. Connors. Detection of high molecular weight amyloid serum protein complexes using Biological On-Line Tracer Sedimentation (BOLTS) Analytical Biochemistry

February 2012

February 29th, 2012 in Uncategorized

Pathology & Laboratory Medicine News Items

Announcements:

  • The feature article for the February CR Times, “Taking the Bite Out of the BARC: Getting Specimens from the BUMC Biospecimen Archive Research Core is Easier Than You Think!”  is about the BARC this month and was written by Dr. Robert Pistey, BARC Director,  Cheryl Spencer, MA, BARC Manager and an IRB senior analyst.
  • Dr. Michael O’Brien has a featured article in this week’s New England Journal of Medicine: Ann G. Zauber, Ph.D., Sidney J. Winawer, M.D., Michael J. O’Brien, M.D., M.P.H., Iris Lansdorp-Vogelaar, Ph.D., Marjolein van Ballegooijen, M.D., Ph.D., Benjamin F. Hankey, Sc.D., Weiji Shi, M.S., John H. Bond, M.D., Melvin Schapiro, M.D., Joel F. Panish, M.D., Edward T. Stewart, M.D., and Jerome D. Waye, M.D. Colonoscopic Polypectomy and Long-Term Prevention of Colorectal-Cancer Deaths New England Journal of Medicine 2012; 366:687 – 696 February 23, 2012
  • Ben Brugmann, a PhD student in Dr. Susan Winandy’s Lab, was chosen for an oral presentation at the 99th Annual American Association of Immunologists (AAI) Meeting that will take place in Boston in May.
  • Dr. Susan Winandy was chosen to chair the “Hematopoietic Stem Cells and Lineage Fate Decisions” workshop session at the AAI Meeting
  • This past October Dean Karen Antman asked for anyone who had artistic science images to submit them for a Science Art Competition. David Stepien, MD/PhD candidate and Jacqueline Bouchard, PhD candidate in the Remick Lab submitted some images created from experiments in the lab. The selected winning images were unveiled recently at the medical student research forum; they will be displayed around campus and on the flat screen panels located in the medical school lobby. Attached are David’s 4 images and Jackie’s 2 images that won:
ImageJ=1.42q ImageJ=1.42q Stepien 1
Stepien 3 Stepien 2 Stepien 4

 

  • Tricia Kao, PhD candidate in the Delalle Lab presented a poster at the 40th Annual Meeting of the International Neuropsychological Society in Montreal, Canada, February 15-18, 2012, entitled “Exosomal miRNA profiling in prefrontal cortices of patients diagnosed with bipolar disorder and schizophrenia”, authored by Meredith G. Banigan, Patricia F. Kao, James Kozubek, Juan Medina, Joan Costa, Andrea Schmitt, Ivana Delalle and Charles R Vanderburg. This work is a result of our laboratory collaboration with Harvard NeuroDiscovery Center (Banigan, Vanderburg), UConn Genetics Dept (Kozubek), and Brain-Net Europe – an international organization of brain tissue depositories (Medina, Costa, Schmitt).
  • Resident Dr. Manisha Mehta’s poster got accepted for the “ARVO” (The Association for Research in Vision and Ophthalmology) Conference. This is an international conference to be held in Fort Lauderdale, Florida (May 6-10, 2012). Manisha will be presenting her poster on May 8th. Poster details:  “PDCL3 Regulates Endothelial Cell Proliferation And Angiogenesis Through The Generation Of Functional VEGFR-2”;  Manisha Mehta, Srimathi Srinivasan, Rosana D Meyer, Ricardo Lugo, Vipul Chitalia, Nora Laver, Nader Rahimi.
  • Kazem Azadzoi, MD has received a VA Merit Review grant award funded for 4 years to study the role of oxidative stress in bladder overactivity and lower urinary tract symptoms

 

Publications: PUBLISHED

  • McMillin DW, Jacobs HM, Delmore JE, Buon L, Hunter ZR, Monrose V, Yu J, Smith PG, Richardson PG, Anderson KC, Treon SP, Kung AL, Mitsiades CS. Molecular and cellular effects of NEDD8 activating enzyme (NAE) inhibition in myeloma. Molecular Cancer Ther. 2012 Jan 12
  • Ojha RP, Hanzis CA, Hunter ZR, Greenland S, Offutt-Powell TN, Manning RJ, Lewicki M, Brodsky PS, Ioakimidis L, Tripsas CK, Patterson CJ, Sheehy P, Singh KP, Treon SP.  Family history of non-hematologic cancers among Waldenstrom macroglobulinemia patients: A preliminary study. Cancer Epidemiology. 2011 Nov 16
  • Hangun Kim,  Yongfeng He,  Ilhwan Yang, Yan Zeng, Yonghee Kim, Young-Woo Seo, Mary Jo Murnane, Chaeyong Jung, Jae-Hyuk Lee,  Jeong-Joon Min, Dong-Deuk Kwon,  Kyung Keun Kim, Qun Lu, Kwonseop Kim.    δ-Catenin promotes E-cadherin processing and activates β-catenin-mediated signaling: Implications on human prostate cancer progression. Biochimica et Biophysica Acta 1822 (2012) 509–521. Interesting to note: Kwonseop Kim was one of Dr. Murnane’s PhD students back in the 1990’s
  • Carmen D. Sarita-Reyes, M. Alba Greco, German C. Steiner. Mesenchymal–Epithelial Differentiation of Adamantinoma of Long Bones: An Immunohistochemical and Ultrastructural Study. Ultrastructural Pathology February 2012, Vol. 36, No. 1 , Pages 23-30 (doi:10.3109/01913123.2011.631725)
  • Dave Sherr, PhD just had a commentary accepted in Nature Immunology volume 13 number 2 FEBRUARY 2012: