Recap of GSI Supported MS Bioinformatics Internship Program
The MS Bioinformatics Program held a successful internship program with the support of the Genome Science Institute. The program was mentored by Dr. Gargi Dayama and Dr. Joey Orofino. Six GSI faculty members participated in the internship program, hosting several bioinformatics students. “RNA sequencing and proteomics analysis to identify molecular pathways implicated in the development of aortic aneurysms,” a project analyzed by Kyra Griffin-Mitchell was overseen by Dr. Francesca Seta. Seta states, “the program is terrific in the sense that it is a win-win: for us (who have datasets but not the expertise to properly analyze, and for the students who have the expertise but not the dataset.” GSI faculty, Dr. Ella Zeldich hosted Raghad Yamani for the summer to investigate “Using scRNAseq to investigate the use of mesenchymal stromal-cell derived extracellular vesicles in mitigating pathogenic signaling in human oligocortical spheroids.” “Dr. Dayama, who led the bioinformatics mentoring (together with Dr. Adam Labadorf), was extremely supportive, knowledgeable, professional, and creative. The results of this project surpassed all the expectations and this is probably the ultimate set up for the collaboration between the bioinformatics and biology teams,” Zeldich commented.
Collaborated Internship Projects:
“Graph database representations of clinical and ‘omics data” Dr. Falk / Dr. Labadorf and intern Merai Dandouch
“scRNA analysis of mouse and human neurons to understand early Alzheimer’s disease related pathogenesis in the entorhinal cortex” Dr. Jean-Pierre Roussarie and intern, Manas Dhanuka
“RNA sequencing and proteomics analysis to identify molecular pathways implicated in the development of aortic aneurysms” Dr. Francesca Seta and intern, Kyra Griffin-Mitchell
“Building a comprehensive soil metagenome database” Dr. Jenny Bhatnagar and intern, Daniel Golden
“Characterizing epigenetic changes to study the mechanisms of stem cell driven epithelial tissue regeneration using RNAseq, ATACseq, HiC” Dr. Andrei Sharov and intern, Go Ogata
“Examining the link between diet and epigenetic regulation of gene expression in various brain regions in an Alzheimer’s disease mouse model” Dr. Krzysztof Blusztajn and intern, Navin Ramanan
“Using scRNAseq to investigate the use of mesenchymal stromal-cell derived extracellular vesicles in mitigating pathogenic signaling in human oligocortical spheroids” Dr. Ella Zeldich and intern, Raghad Yamani