Cryogenic Electron Microscopy Core
The Boston University Cryogenic Electron Microscopy (BU Cryo-EM) Core Facility is a custom-designed microscope facility located at the Center for Advanced Biomedical Research on the BU Medical Campus. We are committed to providing exceptional instrumentation, training, and advice for researchers looking to answer their scientific questions using cryo-EM/cryo-ET techniques. Our goal is to provide technical and scientific support for the entire cryo-EM/cryo-ET workflow including sample preparation, data collection, and data processing.
Instruments and Services
Description
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Electron Microscope Glacios-2 Cryo-TEM – estimated to be operational in June 2024
- X-FEG electron source
- 12-slot sample autoloader
- Selectris X energy filter
- Falcon 4i camera
- Ceta-D camera (for MicroED)
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Other Instruments
- Vitrobot Mark IV – Estimated to be delivered June 2024
- Vitrobot Mark V (to replace the Vitrobot Mark IV) – To be delivered late 2025
- Pelco easiGlow Glow Discharge Unit
- Grid Clipping Stations
- Autoloader Cassette Loading Station
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Software
- EPU with Multigrid functionality
- CryoSPARC LIVE
- VNC access for remote grid screening and data collection
- SmartEPU with Quality Monitor
- TEM tomography data acquisition software – Estimated to be operational June 2024
- SerialEM – Estimated to be operational late 2024
- Maps 3 for S/TEM with Correlative Workflow – Estimated to be operational late 2024
- MicroED software package – Estimated to be operational late 2024
Software use is included with the microscope and instrument use rates.
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How to Schedule
Interested new users, please email the BU Cryo-EM Core Facility at cryoem@bu.edu to schedule an initial consultation to discuss how we can best meet your microscope needs and scientific goals.
Cryogenic Electron Microscopy
Contact
Esther Bullitt, PhD
Professor and Core Facility Director (Team Lead)
bullitt@bu.edu
Chad Hicks, PhD
Cryo-EM Scientist (Core Facility Manager)
hickscw@bu.edu
Christopher Akey, PhD
Professor (Core Facility Advisor)
cakey@bu.edu
Location
Center for Advanced Biomedical Research (CABR)
700 Albany St., Room W-110A
Boston, MA 02118
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