Expertise and interests include:
REGULATION OF STEM CELL FUNCTION AND AGING BY HEPARAN SULFATE AND SULFS:
Environmental signals play crucial roles in self-renewal of stem cells, tissue regeneration and aging. Ai lab investigates heparan sulfate-dependent mechanisms that regulate extracellular signaling during stem cell maintenance and regeneration of the skeletal muscle. Our study is focused on two heparan sulfate-modifying enzymes called Sulfs.
NEUROGENESIS AND NEUROPLASTICITY IN PULMONARY DISEASES:
The respiratory tract is known to be innervated by two groups of neurons. The intrinsic neurons have cell bodies located within the tissue, while the extrinsic neurons have their cell bodies located in the central and peripheral nervous system and their axons innervating airway smooth muscle and neuroendocrine cells. Ai lab investigates neurotrophic signals that regulate neurogenesis in developing lung and neuroplasticity in pulmonary diseases. Our goal is to understand physiological roles of neural innervation in respiratory function, diseases and regeneration.
AIRWAY SMOOTH MUSCLE DEVELOPMENT AND REMODELING IN ASTHMA:
Airway smooth muscle hyperplasia and hyper-reactivity are key features of asthma. Ai lab, in collaboration with Dr. Alan Fine’s lab, investigates mechanisms underlying the formation and remodeling of airway smooth muscle. We are particularly interested in the sonic hedgehog pathway in control of airway smooth muscle development.
- Member, Evans Center for Interdisciplinary Biomedical Research, Boston University
- Case Western Reserve University, PhD
- Fudan University, BS
- Published on 9/21/2023
Zhao C, Wang W, Bai Y, Amonkar G, Mou H, Olejnik J, Hume AJ, Mühlberger E, Fang Y, Que J, Fearns R, Ai X, Lerou PH. Age-related STAT3 signaling regulates severity of respiratory syncytial viral infection in human bronchial epithelial cells. bioRxiv. 2023 Sep 21. PMID: 37781574.
- Published on 9/12/2023
Bankoti K, Wang W, Amonkar GM, Xiong L, Shui JE, Zhao C, Van E, Mwase C, Park JA, Mou H, Fang Y, Que J, Bai Y, Lerou PH, Ai X. Airway Basal Stem Cells in COVID-19 Exhibit a Proinflammatory Signature and Impaired Mucocililary Differentiation. Am J Respir Cell Mol Biol. 2023 Sep 12. PMID: 37699145.
- Published on 6/6/2023
Bai Y, Li G, Yung L, Yu PB, Ai X. Intrapulmonary arterial contraction assay reveals region-specific deregulation of vasoreactivity to lung injuries. Am J Physiol Lung Cell Mol Physiol. 2023 Aug 01; 325(2):L114-L124. PMID: 37278410.
- Published on 6/1/2023
Zhang Y, Black KE, Phung TN, Thundivalappil SR, Lin T, Wang W, Xu J, Zhang C, Hariri LP, Lapey A, Li H, Lerou PH, Ai X, Que J, Park JA, Hurley BP, Mou H. Human Airway Basal Cells Undergo Reversible Squamous Differentiation and Reshape Innate Immunity. Am J Respir Cell Mol Biol. 2023 Jun; 68(6):664-678. PMID: 36753317.
- Published on 2/24/2023
Wang W, Garcia C, Shao F, Cohen JA, Bai Y, Fine A, Ai X. Lung dopaminergic nerves facilitate the establishment of TH2 resident memory cells in early life. J Allergy Clin Immunol. 2023 Aug; 152(2):386-399. PMID: 36841266.
- Published on 1/3/2023
Krishnamoorthy N, Walker KH, Brüggemann TR, Tavares LP, Smith EW, Nijmeh J, Bai Y, Ai X, Cagnina RE, Duvall MG, Lehoczky JA, Levy BD. The Maresin 1-LGR6 axis decreases respiratory syncytial virus-induced lung inflammation. Proc Natl Acad Sci U S A. 2023 Jan 10; 120(2):e2206480120. PMID: 36595677.
- Published on 5/5/2022
Bai Y, Ai X. Utilizing the Precision-Cut Lung Slice to Study the Contractile Regulation of Airway and Intrapulmonary Arterial Smooth Muscle. J Vis Exp. 2022 May 05; (183). PMID: 35604150.
- Published on 11/18/2021
Bai Y, Guedes AGP, Krishnan R, Ai X. CD38 plays an age-related role in cholinergic deregulation of airway smooth muscle contractility. J Allergy Clin Immunol. 2022 May; 149(5):1643-1654.e8. PMID: 34800431.
- Published on 8/14/2021
Wang W, Ai X. Primary culture of immature, naïve mouse CD4+ T cells. STAR Protoc. 2021 Sep 17; 2(3):100756. PMID: 34430922.
- Published on 7/13/2021
Hicks-Berthet J, Ning B, Federico A, Tilston-Lunel A, Matschulat A, Ai X, Lenburg ME, Beane J, Monti S, Varelas X. Yap/Taz inhibit goblet cell fate to maintain lung epithelial homeostasis. Cell Rep. 2021 07 13; 36(2):109347. PMID: 34260916.
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