Weiwei Lin, PhD
Assistant Professor, Pharmcology, Physiology & Biophysics
Biography
My research aims to use the power of precision mass spectrometry towards functional multi-omics-based systems biology to uncover the molecular networks altered in Alzheimer’s disease and other brain pathologies.
A) Mapping protein-protein interactions linked to AD progression and other neurodegenerative diseases.
B) High-resolution LC-MS-based integrative metabolomic and proteomic platform development and application.
C) Brain disease-associated native protein complexes.
Websites
Education
- Peking University, PhD
- Guangzhou Medical College, MMed
- Guangdong Medical & Pharmaceutical, BS
Publications
- Published on 4/5/2025
Lin W, Mousavi F, Blum BC, Heckendorf CF, Lawton M, Lampl N, Hekman R, McComb M, Emili A. Protocol for dual metabolomics and proteomics using nanoflow liquid chromatography-tandem mass spectrometry. STAR Protoc. 2025 Apr 05; 6(2):103745. PMID: 40188434.
Read at: PubMed - Published on 12/17/2024
Lawton ML, Inge MM, Blum BC, Smith-Mahoney EL, Bolzan D, Lin W, McConney C, Porter J, Moore J, Youssef A, Tharani Y, Varelas X, Denis GV, Wong WW, Padhorny D, Kozakov D, Siggers T, Wuchty S, Snyder-Cappione J, Emili A. Multiomic profiling of chronically activated CD4+ T cells identifies drivers of exhaustion and metabolic reprogramming. PLoS Biol. 2024 Dec; 22(12):e3002943. PMID: 39689157.
Read at: PubMed - Published on 10/16/2024
Lagani GD, Sha M, Lin W, Natarajan S, Kankkunen M, Kistler SA, Lampl N, Waxman H, Harper ER, Emili A, Beffert U, Ho A. Beyond Glycolysis: Aldolase A Is a Novel Effector in Reelin-Mediated Dendritic Development. J Neurosci. 2024 Oct 16; 44(42). PMID: 39227156.
Read at: PubMed - Published on 9/14/2024
Zhang Z, Lin W, Gan Q, Lei M, Gong B, Zhang C, Henrique JS, Han J, Tian H, Tao Q, Potempa LA, Stein TD, Emili A, Qiu WQ. The influences of ApoE isoforms on endothelial adherens junctions and actin cytoskeleton responding to mCRP. Angiogenesis. 2024 Nov; 27(4):861-881. PMID: 39276310.
Read at: PubMed - Published on 7/2/2024
Lin W, Mousavi F, Blum BC, Heckendorf CF, Lawton M, Lampl N, Hekman R, Guo H, McComb M, Emili A. PANAMA-enabled high-sensitivity dual nanoflow LC-MS metabolomics and proteomics analysis. Cell Rep Methods. 2024 Jul 15; 4(7):100803. PMID: 38959888.
Read at: PubMed - Published on 1/12/2024
Lagani GD, Lin W, Natarajan S, Lampl N, Harper ER, Emili A, Beffert U, Ho A. Beyond Glycolysis: Aldolase A is a Novel Effector in Reelin Mediated Dendritic Development. bioRxiv. 2024 Jan 12. PMID: 38260505.
Read at: PubMed - Published on 11/27/2023
Lin W, Mousavi F, Blum BC, Heckendorf CF, Moore J, Lampl N, McComb M, Kotelnikov S, Yin W, Rabhi N, Layne MD, Kozakov D, Chitalia VC, Emili A. Integrated metabolomics and proteomics reveal biomarkers associated with hemodialysis in end-stage kidney disease. Front Pharmacol. 2023; 14:1243505. PMID: 38089059.
Read at: PubMed - Published on 3/1/2023
Moore J, Ewoldt J, Venturini G, Pereira AC, Padilha K, Lawton M, Lin W, Goel R, Luptak I, Perissi V, Seidman CE, Seidman J, Chin MT, Chen C, Emili A. Multi-Omics Profiling of Hypertrophic Cardiomyopathy Reveals Altered Mechanisms in Mitochondrial Dynamics and Excitation-Contraction Coupling. Int J Mol Sci. 2023 Mar 01; 24(5). PMID: 36902152.
Read at: PubMed - Published on 2/8/2023
Paul I, Bolzan D, Youssef A, Gagnon KA, Hook H, Karemore G, Oliphant MUJ, Lin W, Liu Q, Phanse S, White C, Padhorny D, Kotelnikov S, Chen CS, Hu P, Denis GV, Kozakov D, Raught B, Siggers T, Wuchty S, Muthuswamy SK, Emili A. Parallelized multidimensional analytic framework applied to mammary epithelial cells uncovers regulatory principles in EMT. Nat Commun. 2023 Feb 08; 14(1):688. PMID: 36755019.
Read at: PubMed - Published on 1/1/2023
Heckendorf C, Blum BC, Lin W, Lawton ML, Emili A. Integration of Metabolomic and Proteomic Data to Uncover Actionable Metabolic Pathways. Methods Mol Biol. 2023; 2660:137-148. PMID: 37191795.
Read at: PubMed
View 12 more publications: View full profile at BUMC