Weiwei Lin, PhD

Assistant Professor, Boston University Chobanian & Avedisian School of Medicine

Biography

My research aims to use the power of precision mass spectrometry towards functional multi-omics-based systems biology to uncover the molecular networks altered in Alzheimer’s disease and other brain pathologies.
A) Mapping protein-protein interactions linked to AD progression and other neurodegenerative diseases.
B) High-resolution LC-MS-based integrative metabolomic and proteomic platform development and application.
C) Brain disease-associated native protein complexes.

Publications

  • Published 4/5/2025

    Lin W, Mousavi F, Blum BC, Heckendorf CF, Lawton M, Lampl N, Hekman R, McComb M, Emili A. Protocol for dual metabolomics and proteomics using nanoflow liquid chromatography-tandem mass spectrometry. STAR Protoc. 2025 Apr 05; 6(2):103745. PMID: 40188434.

    Read at: PubMed

  • Published 12/17/2024

    Lawton ML, Inge MM, Blum BC, Smith-Mahoney EL, Bolzan D, Lin W, McConney C, Porter J, Moore J, Youssef A, Tharani Y, Varelas X, Denis GV, Wong WW, Padhorny D, Kozakov D, Siggers T, Wuchty S, Snyder-Cappione J, Emili A. Multiomic profiling of chronically activated CD4+ T cells identifies drivers of exhaustion and metabolic reprogramming. PLoS Biol. 2024 Dec; 22(12):e3002943. PMID: 39689157.

    Read at: PubMed

  • Published 10/16/2024

    Lagani GD, Sha M, Lin W, Natarajan S, Kankkunen M, Kistler SA, Lampl N, Waxman H, Harper ER, Emili A, Beffert U, Ho A. Beyond Glycolysis: Aldolase A Is a Novel Effector in Reelin-Mediated Dendritic Development. J Neurosci. 2024 Oct 16; 44(42). PMID: 39227156.

    Read at: PubMed

  • Published 9/14/2024

    Zhang Z, Lin W, Gan Q, Lei M, Gong B, Zhang C, Henrique JS, Han J, Tian H, Tao Q, Potempa LA, Stein TD, Emili A, Qiu WQ. The influences of ApoE isoforms on endothelial adherens junctions and actin cytoskeleton responding to mCRP. Angiogenesis. 2024 Nov; 27(4):861-881. PMID: 39276310.

    Read at: PubMed

  • Published 7/2/2024

    Lin W, Mousavi F, Blum BC, Heckendorf CF, Lawton M, Lampl N, Hekman R, Guo H, McComb M, Emili A. PANAMA-enabled high-sensitivity dual nanoflow LC-MS metabolomics and proteomics analysis. Cell Rep Methods. 2024 Jul 15; 4(7):100803. PMID: 38959888.

    Read at: PubMed

View All 22 Publications:   View Full Profile in BUMC

Websites

Education

  • Peking University, PhD
  • Guangzhou Medical College, MMed
  • Guangdong Medical & Pharmaceutical, BS

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