The primary research focus of our lab is the biology of aging and understanding the basic mechanisms that underlie the pathogenesis of age-related diseases. We are particularly interested in studying the nature of senescence factors and understanding how stress response signaling regulates aging. In our work we utilize ribosome profiling and next-generation sequencing, and a combination of molecular and biochemical approaches to look at transcriptional and translational changes that are associated with the aging process as well as the mechanisms of such regulation in eukaryotic cells. A second major focus of the laboratory is synthetic biology and developing new bioengineering approaches that can be used to study complex traits, such as longevity, using yeast S. cerevisiae as a model organism.
We hope that our studies will provide a better understanding of the mechanisms that regulate aging and will help to identify new targets for therapeutic intervention for age-related diseases.
- Assistant Professor, Biochemistry & Cell Biology, Boston University Chobanian & Avedisian School of Medicine
- Graduate Faculty (Primary Mentor of Grad Students), Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences
- University of Nebraska, PhD
- Donetsk National University, MS
- Donetsk National University, BS
- Published on 7/19/2022
Patnaik PK, Beaupere C, Barlit H, Romero AM, Tsuchiya M, Muir M, Martínez-Pastor MT, Puig S, Kaeberlein M, Labunskyy VM. Deficiency of the RNA-binding protein Cth2 extends yeast replicative lifespan by alleviating its repressive effects on mitochondrial function. Cell Rep. 2022 Jul 19; 40(3):111113. PMID: 35858543.
- Published on 1/1/2021
Barlit H, Rai MK, Shoushtari SI, Beaupere C, Labunskyy VM. Genome-Wide Analysis of Translation in Replicatively Aged Yeast. Methods Mol Biol. 2021; 2252:151-173. PMID: 33765274.
- Published on 12/3/2018
Beaupere C, Labunskyy VM. (Un)folding mechanisms of adaptation to ER stress: lessons from aneuploidy. Curr Genet. 2019 Apr; 65(2):467-471. PMID: 30511161.
- Published on 9/5/2018
Beaupere C, Dinatto L, Wasko BM, Chen RB, VanValkenburg L, Kiflezghi MG, Lee MB, Promislow DEL, Dang W, Kaeberlein M, Labunskyy VM. Genetic screen identifies adaptive aneuploidy as a key mediator of ER stress resistance in yeast. Proc Natl Acad Sci U S A. 2018 09 18; 115(38):9586-9591. PMID: 30185560.
- Published on 12/21/2017
Beaupere C, Chen RB, Pelosi W, Labunskyy VM. Genome-wide Quantification of Translation in Budding Yeast by Ribosome Profiling. J Vis Exp. 2017 12 21; (130). PMID: 29286414.
- Published on 10/10/2017
Lorusso JS, Sviderskiy OA, Labunskyy VM. Emerging Omics Approaches in Aging Research. Antioxid Redox Signal. 2018 10 01; 29(10):985-1002. PMID: 28874057.
- Published on 2/21/2017
Beaupere C, Wasko BM, Lorusso J, Kennedy BK, Kaeberlein M, Labunskyy VM. CAN1 Arginine Permease Deficiency Extends Yeast Replicative Lifespan via Translational Activation of Stress Response Genes. Cell Rep. 2017 Feb 21; 18(8):1884-1892. PMID: 28228255.
- Published on 11/1/2016
Gao J, Barroso C, Zhang P, Kim HM, Li S, Labrador L, Lightfoot J, Gerashchenko MV, Labunskyy VM, Dong MQ, Martinez-Perez E, Colaiácovo MP. N-terminal acetylation promotes synaptonemal complex assembly in C. elegans. Genes Dev. 2016 Nov 01; 30(21):2404-2416. PMID: 27881602.
- Published on 7/1/2014
Labunskyy VM, Hatfield DL, Gladyshev VN. Selenoproteins: molecular pathways and physiological roles. Physiol Rev. 2014 Jul; 94(3):739-77. PMID: 24987004.
- Published on 4/28/2014
Labunskyy VM, Suzuki Y, Hanly TJ, Murao A, Roth FP, Gladyshev VN. The insertion Green Monster (iGM) method for expression of multiple exogenous genes in yeast. G3 (Bethesda). 2014 Jul; 4(7):1183-91. PMID: 24776987.
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