Vyacheslav M. Labunskyy, PhD

Associate Professor, Dermatology

Vyacheslav Labunskyy
609 Albany St (J Bldg)


The primary research focus of our lab is the biology of aging and understanding the basic mechanisms that underlie the pathogenesis of age-related diseases. We are particularly interested in studying the nature of senescence factors and understanding how stress response signaling regulates aging. In our work we utilize ribosome profiling and next-generation sequencing, and a combination of molecular and biochemical approaches to look at transcriptional and translational changes that are associated with the aging process as well as the mechanisms of such regulation in eukaryotic cells. A second major focus of the laboratory is synthetic biology and developing new bioengineering approaches that can be used to study complex traits, such as longevity, using yeast S. cerevisiae as a model organism.

We hope that our studies will provide a better understanding of the mechanisms that regulate aging and will help to identify new targets for therapeutic intervention for age-related diseases.

Other Positions

  • Assistant Professor, Biochemistry & Cell Biology, Boston University Chobanian & Avedisian School of Medicine
  • Graduate Faculty (Primary Mentor of Grad Students), Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences


  • University of Nebraska, PhD
  • Donetsk National University, MS
  • Donetsk National University, BS


  • Published on 4/11/2024

    Puig-Segui MS, Decker CJ, Barlit H, Labunskyy VM, Parker R, Puig S. Regulation of translation in response to iron deficiency in human cells. Sci Rep. 2024 Apr 11; 14(1):8451. PMID: 38605136.

    Read at: PubMed
  • Published on 1/21/2024

    Patnaik PK, Nady N, Barlit H, Gülhan A, Labunskyy VM. Lifespan regulation by targeting heme signaling in yeast. bioRxiv. 2024 Jan 21. PMID: 38293148.

    Read at: PubMed
  • Published on 1/1/2024

    Patnaik PK, Barlit H, Labunskyy VM. Manipulating mRNA-binding protein Cth2 function in budding yeast Saccharomyces cerevisiae. STAR Protoc. 2024 Mar 15; 5(1):102807. PMID: 38165801.

    Read at: PubMed
  • Published on 7/19/2022

    Patnaik PK, Beaupere C, Barlit H, Romero AM, Tsuchiya M, Muir M, Martínez-Pastor MT, Puig S, Kaeberlein M, Labunskyy VM. Deficiency of the RNA-binding protein Cth2 extends yeast replicative lifespan by alleviating its repressive effects on mitochondrial function. Cell Rep. 2022 Jul 19; 40(3):111113. PMID: 35858543.

    Read at: PubMed
  • Published on 1/1/2021

    Barlit H, Rai MK, Shoushtari SI, Beaupere C, Labunskyy VM. Genome-Wide Analysis of Translation in Replicatively Aged Yeast. Methods Mol Biol. 2021; 2252:151-173. PMID: 33765274.

    Read at: PubMed
  • Published on 12/3/2018

    Beaupere C, Labunskyy VM. (Un)folding mechanisms of adaptation to ER stress: lessons from aneuploidy. Curr Genet. 2019 Apr; 65(2):467-471. PMID: 30511161.

    Read at: PubMed
  • Published on 9/5/2018

    Beaupere C, Dinatto L, Wasko BM, Chen RB, VanValkenburg L, Kiflezghi MG, Lee MB, Promislow DEL, Dang W, Kaeberlein M, Labunskyy VM. Genetic screen identifies adaptive aneuploidy as a key mediator of ER stress resistance in yeast. Proc Natl Acad Sci U S A. 2018 09 18; 115(38):9586-9591. PMID: 30185560.

    Read at: PubMed
  • Published on 12/21/2017

    Beaupere C, Chen RB, Pelosi W, Labunskyy VM. Genome-wide Quantification of Translation in Budding Yeast by Ribosome Profiling. J Vis Exp. 2017 12 21; (130). PMID: 29286414.

    Read at: PubMed
  • Published on 10/10/2017

    Lorusso JS, Sviderskiy OA, Labunskyy VM. Emerging Omics Approaches in Aging Research. Antioxid Redox Signal. 2018 10 01; 29(10):985-1002. PMID: 28874057.

    Read at: PubMed
  • Published on 2/21/2017

    Beaupere C, Wasko BM, Lorusso J, Kennedy BK, Kaeberlein M, Labunskyy VM. CAN1 Arginine Permease Deficiency Extends Yeast Replicative Lifespan via Translational Activation of Stress Response Genes. Cell Rep. 2017 Feb 21; 18(8):1884-1892. PMID: 28228255.

    Read at: PubMed

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