Vyacheslav M. Labunskyy, PhD
Associate Professor, Dermatology
Biography
The primary research focus of our lab is the biology of aging and understanding the basic mechanisms that underlie the pathogenesis of age-related diseases. We are particularly interested in studying the nature of senescence factors and understanding how stress response signaling regulates aging. In our work we utilize ribosome profiling and next-generation sequencing, and a combination of molecular and biochemical approaches to look at transcriptional and translational changes that are associated with the aging process as well as the mechanisms of such regulation in eukaryotic cells. A second major focus of the laboratory is synthetic biology and developing new bioengineering approaches that can be used to study complex traits, such as longevity, using yeast S. cerevisiae as a model organism.
We hope that our studies will provide a better understanding of the mechanisms that regulate aging and will help to identify new targets for therapeutic intervention for age-related diseases.
Other Positions
- Assistant Professor, Biochemistry & Cell Biology, Boston University Chobanian & Avedisian School of Medicine
- Graduate Faculty (Primary Mentor of Grad Students), Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences
Education
- University of Nebraska, PhD
- Donetsk National University, MS
- Donetsk National University, BS
Publications
- Published on 12/3/2024
Gladyshev VN, Anderson B, Barlit H, Barré B, Beck S, Behrouz B, Belsky DW, Chaix A, Chamoli M, Chen BH, Cheng K, Chuprin J, Churchill GA, Cipriano A, Colville A, Deelen J, Deigin Y, Edmonds KK, English BW, Fang R, Florea M, Gershteyn IM, Gill D, Goetz LH, Gorbunova V, Griffin PT, Horvath S, Borch Jensen M, Jin X, Jovanovska S, Kajderowicz KM, Kasahara T, Kerepesi C, Kulkarni S, Labunskyy VM, Levine ME, Libert S, Lu JY, Lu YR, Marioni RE, McCoy BM, Mitchell W, Moqri M, Nasirian F, Niimi P, Oh HS, Okundaye B, Parkhitko AA, Peshkin L, Petljak M, Poganik JR, Pridham G, Promislow DEL, Prusisz W, Quiniou M, Raj K, Richard D, Ricon JL, Rutledge J, Scheibye-Knudsen M, Schork NJ, Seluanov A, Shadpour M, Shindyapina AV, Shuken SR, Sivakumar S, Stoeger T, Sugiura A, Sutton NR, Suvorov A, Tarkhov AE, Teeling EC, Trapp A, Tyshkovskiy A, Unfried M, Ward-Caviness CK, Yim SH, Ying K, Yunes J, Zhang B, Zhavoronkov A. Disagreement on foundational principles of biological aging. PNAS Nexus. 2024 Dec; 3(12):pgae499. PMID: 39660064.
Read at: PubMed - Published on 5/29/2024
Patnaik PK, Nady N, Barlit H, Gülhan A, Labunskyy VM. Lifespan regulation by targeting heme signaling in yeast. Geroscience. 2024 Oct; 46(5):5235-5245. PMID: 38809391.
Read at: PubMed - Published on 4/30/2024
Barlit H, Romero AM, Gülhan A, Patnaik PK, Tyshkovskiy A, Martínez-Pastor MT, Gladyshev VN, Puig S, Labunskyy VM. Ribosome profiling reveals the role of yeast RNA-binding proteins Cth1 and Cth2 in translational regulation. iScience. 2024 Jun 21; 27(6):109868. PMID: 38779483.
Read at: PubMed - Published on 4/11/2024
Puig-Segui MS, Decker CJ, Barlit H, Labunskyy VM, Parker R, Puig S. Regulation of translation in response to iron deficiency in human cells. Sci Rep. 2024 Apr 11; 14(1):8451. PMID: 38605136.
Read at: PubMed - Published on 1/21/2024
Patnaik PK, Nady N, Barlit H, Gülhan A, Labunskyy VM. Lifespan regulation by targeting heme signaling in yeast. bioRxiv. 2024 Jan 21. PMID: 38293148.
Read at: PubMed - Published on 1/1/2024
Patnaik PK, Barlit H, Labunskyy VM. Manipulating mRNA-binding protein Cth2 function in budding yeast Saccharomyces cerevisiae. STAR Protoc. 2024 Mar 15; 5(1):102807. PMID: 38165801.
Read at: PubMed - Published on 7/19/2022
Patnaik PK, Beaupere C, Barlit H, Romero AM, Tsuchiya M, Muir M, Martínez-Pastor MT, Puig S, Kaeberlein M, Labunskyy VM. Deficiency of the RNA-binding protein Cth2 extends yeast replicative lifespan by alleviating its repressive effects on mitochondrial function. Cell Rep. 2022 Jul 19; 40(3):111113. PMID: 35858543.
Read at: PubMed - Published on 1/1/2021
Barlit H, Rai MK, Shoushtari SI, Beaupere C, Labunskyy VM. Genome-Wide Analysis of Translation in Replicatively Aged Yeast. Methods Mol Biol. 2021; 2252:151-173. PMID: 33765274.
Read at: PubMed - Published on 12/3/2018
Beaupere C, Labunskyy VM. (Un)folding mechanisms of adaptation to ER stress: lessons from aneuploidy. Curr Genet. 2019 Apr; 65(2):467-471. PMID: 30511161.
Read at: PubMed - Published on 9/5/2018
Beaupere C, Dinatto L, Wasko BM, Chen RB, VanValkenburg L, Kiflezghi MG, Lee MB, Promislow DEL, Dang W, Kaeberlein M, Labunskyy VM. Genetic screen identifies adaptive aneuploidy as a key mediator of ER stress resistance in yeast. Proc Natl Acad Sci U S A. 2018 09 18; 115(38):9586-9591. PMID: 30185560.
Read at: PubMed
View 20 more publications: View full profile at BUMC