Valentina Sabino, PhD

Professor, Boston University Chobanian & Avedisian School of Medicine

Biography

Dr. Sabino co-directs the Laboratory of Addictive Disorders with Dr. Cottone, and she is Professor in the Pharmacology, Physiology & Biophysics Department and in the Psychiatry Department.
Her lab investigates the neurobiological substrates of addiction by exploring the role of neuropeptide systems in excessive alcohol drinking. Research is also aimed to shed light on the neural substrates of stress-related and mood disorders, such as anxiety and depression.

Dr. Sabino is working toward the development of new therapeutic agents to alleviate these highly prevalent psychiatric conditions. The approach of the laboratory is interdisciplinary, involving behavioral neuroscience, neuropharmacology, neuroanatomy, biochemistry, and molecular biology.

Dr. Sabino is highly involved in teaching, as she directs and lectures in several graduate level courses (MD students, Dental students, PhD students, Master's students).

Publications

  • Published 12/28/2023

    Lepeak L, Miracle S, Ferragud A, Seiglie MP, Shafique S, Ozturk Z, Minnig MA, Medeiros G, Cottone P, Sabino V. Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) of the Bed Nucleus of the Stria Terminalis Mediates Heavy Alcohol Drinking in Mice. eNeuro. 2023 Dec; 10(12). PMID: 38053471.

    Read at: PubMed

  • Published 7/25/2023

    Seiglie MP, Lepeak L, Miracle S, Cottone P, Sabino V. Stimulation of lateral parabrachial (LPB) to central amygdala (CeA) pituitary adenylate cyclase-activating polypeptide (PACAP) neurons induces anxiety-like behavior and mechanical allodynia. Pharmacol Biochem Behav. 2023 Sep; 230:173605. PMID: 37499765.

    Read at: PubMed

  • Published 9/21/2022

    Seiglie MP, Lepeak L, Velázquez-Sanchez C, Ferragud A, Le T, Cottone P, Sabino V. The Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) System of the Central Amygdala Mediates the Detrimental Effects of Chronic Social Defeat Stress in Rats. eNeuro. 2022; 9(5). PMID: 36566434.

    Read at: PubMed

  • Published 4/20/2022

    Minnig MA, Blasio A, Ferragud A, Sami YN, Erhard EE, Clark RH, DiLeo A, Giuliano C, Everitt BJ, Cottone P, Sabino V. Pituitary adenylate cyclase-activating polypeptide type 1 receptor within the nucleus accumbens core mediates excessive alcohol drinking in alcohol-preferring rats. Neuropharmacology. 2022 Jul 01; 212:109063. PMID: 35460713.

    Read at: PubMed

  • Published 12/3/2021

    Minnig MA, Park T, Echeveste Sanchez M, Cottone P, Sabino V. Viral-Mediated Knockdown of Nucleus Accumbens Shell PAC1 Receptor Promotes Excessive Alcohol Drinking in Alcohol-Preferring Rats. Front Behav Neurosci. 2021; 15:787362. PMID: 34924973.

    Read at: PubMed

View All 74 Publications:   View Full Profile in BUMC

Other Positions

  • Professor, Psychiatry
    Boston University Chobanian & Avedisian School of Medicine
  • Co-Director of Laboratory of Addictive Disorders, Dean’s Office
    Boston University Chobanian & Avedisian School of Medicine
  • Graduate Faculty (Primary Mentor of Grad Students), Graduate Program for Neuroscience
    Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences

Websites

Education

  • University of Palermo, PhD
  • University of Palermo, PharmD
  • University of Palermo, MS
  • University of Palermo, BS

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