Biography
Tyler Brown is an infectious disease physician, epidemiologist, and Assistant Professor in the Section of Infectious Diseases. His scientific work uses phylogenomics, population genetics, and mathematical modeling to understand how microbial evolution, human host mobility, and other factors shape the transmission and geographic dispersal of tuberculosis and other infectious diseases.
Selected publications (full list available on the Publications tab of this profile):
Brown TS*, Tang L*, Omar SV, Joseph L, Meintjes G, Maartens G, Wasserman S, Shah NS, Farhat MR, Gandhi NR, Ismail N, Brust JCM, Mathema B. Genotype-Phenotype Characterization of Serial Mycobacterium tuberculosis Isolates in Bedaquiline-Resistant Tuberculosis. Clin Infect Dis. 2023 Oct 24. PMID: 37874928; DOI: 10.1093/cid/ciad596 (*co-first authors)
Brown TS, Robinson DA, Buckee CO, Mathema B. Connecting the dots: understanding how human mobility shapes TB epidemics. Trends Microbiol. 2022 Nov; 30(11):1036-1044. PMID: 35597716; PMCID: PMC10068677; DOI: 10.1016/j.tim.2022.04.005
Brown TS, Arogbokun O, Buckee CO, Chang HH. Distinguishing gene flow between malaria parasite populations. PLoS Genet. 2021 Dec; 17(12):e1009335. PMID: 34928954; PMCID: PMC8726502; DOI: 10.1371/journal.pgen.1009335
Brown TS, Eldholm V, Brynildsrud O, Osnes M, Levy N, Stimson J, Colijn C, Alexandru S, Noroc E, Ciobanu N, Crudu V, Cohen T, Mathema B. Evolution and emergence of multidrug-resistant Mycobacterium tuberculosis in Chisinau, Moldova. Microb Genom. 2021 Aug; 7(8). PMID: 34431762; PMCID: PMC8549355; DOI: 10.1099/mgen.0.000620
Brown TS, Engø-Monsen K, Kiang MV, Mahmud AS, Maude RJ, Buckee CO. The impact of mobility network properties on predicted epidemic dynamics in Dhaka and Bangkok. Epidemics. 2021 Jun; 35:100441. PMID: 33667878; PMCID: PMC7899011; DOI: 10.1016/j.epidem.2021.100441
Brown TS, Challagundla L, Baugh EH, Omar SV, Mustaev A, Auld SC, Shah NS, Kreiswirth BN, Brust JCM, Nelson KN, Narechania A, Kurepina N, Mlisana K, Bonneau R, Eldholm V, Ismail N, Kolokotronis SO, Robinson DA, Gandhi NR, Mathema B. Pre-detection history of extensively drug-resistant tuberculosis in KwaZulu-Natal, South Africa. Proc Natl Acad Sci U S A. 2019 Nov 12; 116(46):23284-23291. PMID: 31659018; PMCID: PMC6859317; DOI: 10.1073/pnas.1906636116
Shah NS, Auld SC, Brust JC, Mathema B, Ismail N, Moodley P, Mlisana K, Allana S, Campbell A, Mthiyane T, Morris N, Mpangase P, van der Meulen H, Omar SV, Brown TS, Narechania A, Shaskina E, Kapwata T, Kreiswirth B, Gandhi NR. Transmission of Extensively Drug-Resistant Tuberculosis in South Africa. N Engl J Med. 2017 Jan 19; 376(3):243-253. PMID: 28099825; PMCID: PMC5330208; DOI: 10.1056/NEJMoa1604544