Tsuneya Ikezu, MD, PhD

Adjunct Professor, Boston University Chobanian & Avedisian School of Medicine

Biography

My expertise is biomedical research on neurodegenerative disorders, neuroinflammation, and molecular pharmacologic interventions. Specifically, I have been studying the therapeutic potentials of select anti-inflammatory and neurotrophic factors on animal models of Alzheimer's disease and frontotemporal dementia using virus-mediated gene delivery system. The virus systems include adeno-associated virus, adenovirus, and lentivirus. I have also been investigating the role of innate immunity, more specifically the functions of macrophages and microglia, on HIV-1 infection and neuroinflammation in the context of HIV-associated neurocognitive dysfunction and Alzheimer's disease.

Publications

  • Published 4/1/2025

    Yeapuri P, Machhi J, Foster EG, Kadry R, Bhattarai S, Lu Y, Sil S, Sapkota R, Srivastava S, Kumar M, Ikezu T, Poluektova LY, Gendelman HE, Mosley RL. Amyloid precursor protein and presenilin-1 knock-in immunodeficient mice exhibit intraneuronal Aß pathology, microgliosis, and extensive neuronal loss. Alzheimers Dement. 2025 Apr; 21(4):e70084. PMID: 40195277.

    Read at: PubMed

  • Published 1/25/2025

    Yeh H, De Cruz MA, You Y, Ikezu S, Ikezu T. Development and characterization of in vitro inducible immortalization of a murine microglia cell line for high throughput studies. Sci Rep. 2025 Jan 25; 15(1):3207. PMID: 39863723.

    Read at: PubMed

  • Published 11/30/2024

    Bodart-Santos V, Ruan Z, Melvin BC, Pandey I, Ikezu S, Ikezu T. Selenoprotein P is a target for regulating extracellular vesicle biogenesis and secretion from activated microglia in vivo. Cell Rep. 2024 Dec 24; 43(12):115025. PMID: 39616613.

    Read at: PubMed

  • Published 10/16/2024

    Xu S, Zhang Z, Melvin BC, Basu Ray N, Ikezu S, Ikezu T. Comparison of nanoimaging and nanoflow based detection of extracellular vesicles at a single particle resolution. J Extracell Biol. 2024 Oct; 3(10):e70016. PMID: 39416671.

    Read at: PubMed

  • Published 10/2/2024

    Ikezu T, Yang Y, Verderio C, Krämer-Albers EM. Extracellular Vesicle-Mediated Neuron-Glia Communications in the Central Nervous System. J Neurosci. 2024 Oct 02; 44(40). PMID: 39358029.

    Read at: PubMed

View All 145 Publications:   View Full Profile in BUMC

Other Positions

  • Professor, Neurology
    Boston University Chobanian & Avedisian School of Medicine
  • Member, Evans Center for Interdisciplinary Biomedical Research
    Boston University
  • Graduate Faculty (Primary Mentor of Grad Students)
    Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences

Websites

Education

  • Tokyo Medical and Dental University, MD
  • Tokyo Medical and Dental University, PhD
  • University of Tokyo, BS

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