Thor D. Stein, MD, PhD
Associate Professor, Pathology & Laboratory Medicine
Biography
Dr. Stein completed his undergraduate and graduate studies at the University of Wisconsin- Madison where he earned his MD and PhD (neuroscience) degrees. He completed residency training in pathology and fellowship training in neuropathology at Massachusetts General Hospital. In 2011 he became Assistant Professor of Pathology at Chobanian and Avedisian School of Medicine.
Research Interests:
Dr. Stein’s research interests involve the study of neurodegenerative diseases, including Alzheimer disease and Amyotrophic Lateral Sclerosis (ALS). He studies the role of trauma in the abnormal accumulation of tau and proteins involved in RNA processing. He is an acting neuropathologist involved with the brain banks for the Boston University Alzheimer Disease Center, CTE Center, Framingham Heart Study, as well as the National Veterans Administration ALS brain bank.
CTE Center Role:
Dr. Stein is part of the Neuropathology Core of the SLI-BU CTE Brain Bank, where he conducts neuropathological analysis of brain tissue and helps maintain the SLI-BU CTE Brain Bank.
Awards/Memberships:
Dr. Stein is a recipient of the 2011 American Association of Neuropathologists Moore Award. He is a member of the Society for Neuroscience and the College of American Pathologists.
Other Positions
- Investigator, Framingham Heart Study
- VA Boston Healthcare System
- Member, Evans Center for Interdisciplinary Biomedical Research, Boston University
Websites
Education
- University of Wisconsin Madison, MD
- University of Wisconsin Madison, PhD
- University of Wisconsin Madison, BS
Publications
- Published on 12/6/2024
Nicks R, Shah A, Stathas SA, Kirsch D, Horowitz SM, Saltiel N, Calderazzo SM, Butler MLMD, Cormier KA, Aytan N, Tu-Zahra F, Mathias R, Faheem F, Marcus S, Spurlock E, Fishbein L, Esnault CD, Boden A, Rosen G, Xia W, Daley S, Meng G, Martin BR, Daneshvar DH, Nowinski CJ, Alosco ML, Mez J, Tripodis Y, Huber BR, Alvarez VE, Cherry JD, McKee AC, Stein TD. Neurodegeneration in the cortical sulcus is a feature of chronic traumatic encephalopathy and associated with repetitive head impacts. Acta Neuropathol. 2024 Dec 06; 148(1):79. PMID: 39643767.
Read at: PubMed - Published on 12/2/2024
Abdolmohammadi B, Tuz-Zahra F, Uretsky M, Nicks R, Mosaheb S, Labonte J, Yhang E, Durape S, Martin B, Palmisano J, Nowinski C, Cherry JD, Alvarez VE, Huber BR, Dams-O'Connor K, Crary J, Dwyer B, Daneshvar DH, Goldstein LE, Au R, Katz DI, Kowall NW, Cantu RC, Stern RA, Alosco ML, Stein TD, Tripodis Y, McKee AC, Mez J. Duration of Ice Hockey Play and Chronic Traumatic Encephalopathy. JAMA Netw Open. 2024 Dec 02; 7(12):e2449106. PMID: 39630446.
Read at: PubMed - Published on 11/27/2024
Uretsky M, Nair E, Burton R, Cronin SW, Rousseau D, Tuz-Zahra F, Durape S, Abdolmohammadi B, Baucom Z, Saltiel N, Shah A, Martin B, Palmisano J, Cherry JD, Daneshvar D, Dwyer B, Dams-O'Connor K, Crary J, Goldstein L, Huber B, Katz D, Kowall N, Cantu RC, Alvarez VE, Stern RA, Stein TD, Tripodis Y, McKee AC, Alosco ML, Mez J. Chronic Traumatic Encephalopathy, Family History of Mental Illness, and Aggression in Brain Donors With Repetitive Head Impact Exposure. Neurology. 2024 Dec 24; 103(12):e210056. PMID: 39602665.
Read at: PubMed - Published on 11/13/2024
Li D, Han X, Farrer LA, Stein TD, Jun GR. Transcriptome Signatures for Cognitive Resilience Among Individuals with Pathologically Confirmed Alzheimer Disease. medRxiv. 2024 Nov 13. PMID: 39606402.
Read at: PubMed - Published on 11/6/2024
Krell-Roesch J, Syrjanen JA, Moeller T, Krafft J, Barisch-Fritz B, Kremers WK, Ali F, Knopman DS, Petersen RC, Stein T, Woll A, Vassilaki M, Geda YE. Self-reported physical activity and gait in older adults without dementia: A longitudinal study. Health Sci Rep. 2024 Nov; 7(11):e70108. PMID: 39507676.
Read at: PubMed - Published on 11/4/2024
Safransky M, Groh JR, Blennow K, Zetterberg H, Tripodis Y, Martin B, Weller J, Asken BM, Rabinovici GD, Qiu WWQ, McKee AC, Stein TD, Mez J, Henson RL, Long J, Morris JC, Perrin RJ, Schindler SE, Alosco ML. Lumipulse-Measured Cerebrospinal Fluid Biomarkers for the Early Detection of Alzheimer Disease. Neurology. 2024 Dec 10; 103(11):e209866. PMID: 39496102.
Read at: PubMed - Published on 10/9/2024
Rosen GA, Kirsch D, Nicks R, Kelley H, Mathias R, Cormier KA, Kubilus CA, Dec B, Stein TD, Alvarez VE, Alosco ML, McKee AC, Huber BR. SHARD: an improved method for staining and visualizing multiplex immunofluorescence in optically cleared postmortem human brain tissue. Front Neurosci. 2024; 18:1474617. PMID: 39445075.
Read at: PubMed - Published on 9/24/2024
Giong HK, Hyeon SJ, Lee JG, Cho HJ, Park U, Stein TD, Lee J, Yu K, Ryu H, Lee JS. Tau accumulation is cleared by the induced expression of VCP via autophagy. Acta Neuropathol. 2024 Sep 24; 148(1):46. PMID: 39316141.
Read at: PubMed - Published on 9/14/2024
Zhang Z, Lin W, Gan Q, Lei M, Gong B, Zhang C, Henrique JS, Han J, Tian H, Tao Q, Potempa LA, Stein TD, Emili A, Qiu WQ. The influences of ApoE isoforms on endothelial adherens junctions and actin cytoskeleton responding to mCRP. Angiogenesis. 2024 Nov; 27(4):861-881. PMID: 39276310.
Read at: PubMed - Published on 9/11/2024
O'Neill N, Stein TD, Olayinka OA, Empawi JA, Hu J, Tong T, Zhang X, Farrer LA. Cognitive resilience to Alzheimer's disease characterized by cell-type abundance. Alzheimers Dement. 2024 Oct; 20(10):6910-6921. PMID: 39262221.
Read at: PubMed
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