Biography
Dr. Clarke studied Medical Science at the University of Exeter in the UK, which included a twelve-month research internship at Harvard Medical School. He then pursued a Ph.D. at the University of Birmingham in the laboratory of Dr. Clare Davies, working on understanding the importance of the arginine methyltransferase enzyme, PRMT5, in the DNA damage response (Clarke et al, Molecular Cell; 2017).
After his Ph.D., Dr. Clarke was awarded an EMBO Postdoctoral Fellowship and joined the laboratory of Dr. Johnathan Whetstine at Massachusetts General Hospital and Harvard Medical School, where he worked on elucidating the importance of chromatin dynamics and histone modifications for the regulation of extra chromosomal DNA amplifications (Clarke et al, Cancer Discovery; 2020). After the completion of his EMBO fellowship, Dr. Clarke joined the laboratory of Dr. Raul Mostoslavsky, Scientific Director of the Massachusetts General Hospital Cancer Center, to bridge his interests in chromatin dynamics, DNA damage repair and genome stability maintenance. Funded by fellowships from the Charles King Trust and Massachusetts General Hospital Fund for Medical Discovery, Dr. Clarke has been working to identify and characterize novel chromatin factors involved in DNA damage repair, linking these factors to the pathology of several cancers and human developmental syndromes (Clarke et al, Nature Cell Biology; In Press).
In the summer of 2022, Dr. Clarke became a junior faculty member at Harvard Medical School and The Massachusetts General Hospital Krantz Family Center for Cancer Research. In January 2024, funded by a National Institutes of Health K99/R00 career development award, Dr. Clarke joined the faculty at Boston University School of Medicine as an Assistant Professor to start his independent research laboratory.
Email: tlclarke@bu.edu
Phone: 617-358-1429