Simon Christopher Body, MBChB, MPH, FAHA
Professor, Anesthesiology
Biography
Dr. Body completed his residency and fellowship training in New Zealand. After nearly 30 years of experience at Brigham and Women’s and Beth Israel Hospitals, Dr. Body joined BU School of Medicine in 2020. His clinical expertise is in adult cardiac and thoracic anesthesia.
In 2000, Dr. Body initiated and led a program of examining the genetic influences upon adverse clinical outcomes after coronary artery bypass graft (CABG) surgery. Along with his co-investigators at BWH (Dr. J. Daniel Muehlschlegel), he collected over 2200 patients who had undergone primary CABG as the substrate for this research. Dr. Body and his colleagues are examining the role of variation in candidate genes and their phenotypic expression on adverse postoperative outcomes, specifically atrial fibrillation.
The other major focus of Dr. Body’s research is the genetic causes of bicuspid aortic valve (BAV) disease and its and its consequences – calcific aortic valve disease and aortic aneurysm. Along with his colleagues at US, Canadian and European institutions he has led the International BAV Consortium which has collected over 2,500 patients with a bicuspid aortic valve. His own cohort has over 1,700 BAV patients. These cohorts along with those of the GenTAC program and others from collaborating Investigators are currently being used to determine these genetic causes of BAV. Dr. Body is a member of the GenTAC Alliance and Vice Chair of its Basic Science Working Group.
Dr. Body has published more 220 papers, several book chapter and has been almost continuously funded by the NIH, AHA and other organizations since 2001. He has extensive experience mentoring clinical and research residents, fellows and staff.
Publications
- Published on 2/12/2025
DiGregorio H, Mansoorshahi S, Carlisle SG, Tovar Pensa C, Watts A, McNeely C, Sabate-Rotes A, Yetman A, Michelena HI, De Backer JFA, Mosquera LM, Bissell MM, Andreassi MG, Foffa I, Hui DS, Caffarelli A, Kim YY, Citro R, De Marco M, Tretter JT, McBride KL, Body SC, Milewicz DM, Prakash SK. Contribution of rare chromosome 22q11.2 copy number variants to non-syndromic bicuspid aortic valve. Heart. 2025 Feb 12; 111(5):221-229. PMID: 39658198.
Read at: PubMed - Published on 9/6/2024
Carlisle SG, Albasha H, Michelena HI, Sabate-Rotes A, Bianco L, De Backer J, Mosquera LM, Yetman AT, Bissell MM, Andreassi MG, Foffa I, Hui DS, Caffarelli A, Kim YY, Guo D, Citro R, De Marco M, Tretter JT, McBride KL, Milewicz DM, Body SC, Prakash SK. Rare genomic copy number variants implicate new candidate genes for bicuspid aortic valve. PLoS One. 2024; 19(9):e0304514. PMID: 39240962.
Read at: PubMed - Published on 9/2/2024
Mansoorshahi S, Yetman AT, Bissell MM, Kim YY, Michelena HI, De Backer J, Mosquera LM, Hui DS, Caffarelli A, Andreassi MG, Foffa I, Guo D, Citro R, De Marco M, Tretter JT, Morris SA, Body SC, Chong JX, Bamshad MJ, Milewicz DM, Prakash SK. Whole-exome sequencing uncovers the genetic complexity of bicuspid aortic valve in families with early-onset complications. Am J Hum Genet. 2024 Oct 03; 111(10):2219-2231. PMID: 39226896.
Read at: PubMed - Published on 8/1/2024
Karamnov S, Sarkisian N, Wollborn J, Justice S, Fields K, Kovacheva VP, Osho AA, Sabe A, Body SC, Muehlschlegel JD. Sex, Atrial Fibrillation, and Long-Term Mortality After Cardiac Surgery. JAMA Netw Open. 2024 Aug 01; 7(8):e2426865. PMID: 39167408.
Read at: PubMed - Published on 5/22/2024
Karamnov S, Dimentberg R, Cornella L, Shook DC, Nyman C, Shernan SK, Body SC, Muehlschlegel JD. Fostering a New Generation of Cardiothoracic Anesthesiology Clinician-Scientists: A Systematic Approach. J Cardiothorac Vasc Anesth. 2024 Oct; 38(10):2169-2172. PMID: 38955618.
Read at: PubMed - Published on 3/13/2024
Selbst MA, Laughlin MK, Ward CR, Michelena H, Sabate-Rotes A, Bianco L, De Backer J, Mosquera LM, Yetman AT, Bissell MM, Andreassi MG, Foffa I, Hui DS, Caffarelli A, Kim YY, Guo D, Citro R, De Marco M, Tretter JT, Morris SA, McBride KL, Body SC, Prakash SK. Bicuspid Aortic Valve Disease With Early Onset Complications: Characteristics And Aortic Outcomes. medRxiv. 2024 Mar 13. PMID: 38559132.
Read at: PubMed - Published on 2/8/2024
Mansoorshahi S, Yetman AT, Bissell MM, Kim YY, Michelena H, Hui DS, Caffarelli A, Andreassi MG, Foffa I, Guo D, Citro R, De Marco M, Tretter JT, Morris SA, Body SC, Chong JX, Bamshad MJ, Milewicz DM, Prakash SK. Whole Exome Sequencing Uncovers the Genetic Complexity of Bicuspid Aortic Valve in Families with Early Onset Complications. medRxiv. 2024 Feb 08. PMID: 38370698.
Read at: PubMed - Published on 10/24/2023
Carlisle SG, Albasha H, Michelena H, Sabate-Rotes A, Bianco L, De Backer J, Mosquera LM, Yetman AT, Bissell MM, Andreassi MG, Foffa I, Hui DS, Caffarelli A, Kim YY, Guo DC, Citro R, De Marco M, Tretter JT, McBride KL, Milewicz DM, Body SC, Prakash SK. Rare Genomic Copy Number Variants Implicate New Candidate Genes for Bicuspid Aortic Valve. medRxiv. 2023 Oct 24. PMID: 37961530.
Read at: PubMed - Published on 9/29/2023
Asher SR, Ong CS, Malapero RJ, Heydarpour M, Malzberg GW, Shahram JT, Nguyen TB, Shook DC, Shernan SK, Shekar P, Kaneko T, Citro R, Muehlschlegel JD, Body SC. Effect of concurrent mitral valve surgery for secondary mitral regurgitation upon mortality after aortic valve replacement or coronary artery bypass surgery. Front Cardiovasc Med. 2023; 10:1202174. PMID: 37840960.
Read at: PubMed - Published on 8/1/2023
Tessler I, Albuisson J, Piñeiro-Sabarís R, Verstraeten A, Kamber Kaya HE, Siguero-Álvarez M, Goudot G, MacGrogan D, Luyckx I, Shpitzen S, Levin G, Kelman G, Reshef N, Mananet H, Holdcraft J, Muehlschlegel JD, Peloso GM, Oppenheim O, Cheng C, Mazzella JM, Andelfinger G, Mital S, Eriksson P, Billon C, Heydarpour M, Dietz HC, Jeunemaitre X, Leitersdorf E, Sprinzak D, Blacklow SC, Body SC, Carmi S, Loeys B, de la Pompa JL, Gilon D, Messas E, Durst R. Novel Association of the NOTCH Pathway Regulator MIB1 Gene With the Development of Bicuspid Aortic Valve. JAMA Cardiol. 2023 Aug 01; 8(8):721-731. PMID: 37405741.
Read at: PubMed
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