Shawn Lyons, PhD

Assistant Professor, Boston University Chobanian & Avedisian School of Medicine

Biography

Shawn Lyons obtained his Ph.D. in the laboratory of Dr. William Marzluff at UNC working on histone mRNA metabolism. He was a postdoctoral fellow with Dr. Paul Anderson at Harvard Medical School (Brigham and Women’s) and worked on the regulation of protein synthesis during acute stress response in cells, in particular how RNA metabolism and ribosome biogenesis are altered in response to stress.

Publications

  • Published 5/12/2026

    Wacquiez A, Hboub H, Chen DY, Tavares AH, Su CM, De Paz J, Semaan M, Ding Z, Zaia J, Sethi MK, Lyons SM, Saeed M. The enteroviral protease target LSM14A operates outside of P-bodies to augment antiviral innate immunity. bioRxiv. 2026 May 12. PMID: 42182482.

    Read at: PubMed

  • Published 4/7/2026

    Johnston R, Brekker MA, Khalil N, Goldstein ME, Aldrich A, Grimins AO, Gritli S, Marintchev A, Blower MD, Saeed M, Lyons SM. Proteolytic dissection of eIF4G reveals the closed-loop mRNP as an architecture for translation repression. bioRxiv. 2026 Apr 07. PMID: 41993452.

    Read at: PubMed

  • Published 1/14/2026

    Sparago E, Johnston R, Lyons SM, Blower MD. Decreased tRNA abundance contributes to decreased translation elongation rate in a prolonged mitosis. bioRxiv. 2026 Jan 14. PMID: 41648386.

    Read at: PubMed

  • Published 6/20/2025

    Kharel P, Bhatter N, Zubair S, Lyons SM, Anderson PJ, Ivanov P. G-quadruplex topologies determine the functional outcome of guanine-rich bioactive oligonucleotides. Nucleic Acids Res. 2025 Jun 20; 53(12). PMID: 40580035.

    Read at: PubMed

  • Published 12/1/2024

    Kharel P, Bhatter N, Zubair S, Lyons S, Anderson PJ, Ivanov P. G-quadruplex topologies determine the functional outcome of guanine-rich bioactive oligonucleotides. bioRxiv. 2024 Dec 01. PMID: 39651178.

    Read at: PubMed

View All 54 Publications:   View Full Profile in BUMC

Websites

Education

  • University of North Carolina at Chapel Hill, PhD
  • New York University, MS
  • University of North Carolina at Chapel Hill, BS

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