Shawn Lyons, PhD

Assistant Professor, Biochemistry & Cell Biology

Shawn Lyons


Shawn Lyons obtained his Ph.D. in the laboratory of Dr. William Marzluff at UNC working on histone mRNA metabolism. He was a postdoctoral fellow with Dr. Paul Anderson at Harvard Medical School (Brigham and Women’s) and worked on the regulation of protein synthesis during acute stress response in cells, in particular how RNA metabolism and ribosome biogenesis are altered in response to stress.


  • University of North Carolina at Chapel Hill, PhD
  • New York University, MS
  • University of North Carolina at Chapel Hill, BS


  • Published on 11/13/2023

    Nelson EV, Ross SJ, Olejnik J, Hume AJ, Deeney DJ, King E, Grimins AO, Lyons SM, Cifuentes D, Mühlberger E. The 3' Untranslated Regions of Ebola Virus mRNAs Contain AU-Rich Elements Involved in Posttranscriptional Stabilization and Decay. J Infect Dis. 2023 Nov 13; 228(Supplement_7):S488-S497. PMID: 37551415.

    Read at: PubMed
  • Published on 9/20/2023

    Werder RB, Berthiaume KA, Merritt C, Gallagher M, Villacorta-Martin C, Wang F, Bawa P, Malik V, Lyons SM, Basil MC, Morrisey EE, Kotton DN, Zhou X, Cho MH, Wilson AA. The COPD GWAS gene ADGRG6 instructs function and injury response in human iPSC-derived type II alveolar epithelial cells. Am J Hum Genet. 2023 Oct 05; 110(10):1735-1749. PMID: 37734371.

    Read at: PubMed
  • Published on 5/26/2023

    Reiss M, Keegan J, Aldrich A, Lyons SM, Flynn RL. The exoribonuclease XRN2 mediates degradation of the long non-coding telomeric RNA TERRA. FEBS Lett. 2023 Jul; 597(14):1818-1836. PMID: 37191774.

    Read at: PubMed
  • Published on 4/6/2023

    Paget M, Cadena C, Ahmad S, Wang HT, Jordan TX, Kim E, Koo B, Lyons SM, Ivanov P, tenOever B, Mu X, Hur S. Stress granules are shock absorbers that prevent excessive innate immune responses to dsRNA. Mol Cell. 2023 Apr 06; 83(7):1180-1196.e8. PMID: 37028415.

    Read at: PubMed
  • Published on 3/1/2022

    Akiyama Y, Lyons SM, Fay MM, Tomioka Y, Abe T, Anderson PJ, Ivanov P. Selective Cleavage at CCA Ends and Anticodon Loops of tRNAs by Stress-Induced RNases. Front Mol Biosci. 2022; 9:791094. PMID: 35300117.

    Read at: PubMed
  • Published on 1/25/2022

    Szaflarski W, Lesniczak-Staszak M, Sowinski M, Ojha S, Aulas A, Dave D, Malla S, Anderson P, Ivanov P, Lyons SM. Early rRNA processing is a stress-dependent regulatory event whose inhibition maintains nucleolar integrity. Nucleic Acids Res. 2022 01 25; 50(2):1033-1051. PMID: 34928368.

    Read at: PubMed
  • Published on 12/17/2021

    Fernandes N, Nero L, Lyons SM, Ivanov P, Mittelmeier TM, Bolger TA, Buchan JR. Correction: Fernandes et al. Stress Granule Assembly Can Facilitate but Is Not Required for TDP-43 Cytoplasmic Aggregation. Biomolecules 2020, 10, 1367. Biomolecules. 2021 Dec 17; 11(12). PMID: 34944560.

    Read at: PubMed
  • Published on 12/1/2021

    Pietras P, Aulas A, Fay MM, Lesniczak-Staszak M, Sowinski M, Lyons SM, Szaflarski W, Ivanov P. Translation inhibition and suppression of stress granules formation by cisplatin. Biomed Pharmacother. 2022 Jan; 145:112382. PMID: 34864307.

    Read at: PubMed
  • Published on 11/9/2021

    Pietras P, Lesniczak-Staszak M, Kasprzak A, Andrzejewska M, Jopek K, Sowinski M, Rucinski M, Lyons SM, Ivanov P, Szaflarski W. MVP Expression Facilitates Tumor Cell Proliferation and Migration Supporting the Metastasis of Colorectal Cancer Cells. Int J Mol Sci. 2021 Nov 09; 22(22). PMID: 34829999.

    Read at: PubMed
  • Published on 9/20/2021

    Floro J, Dai A, Metzger A, Mora-Martin A, Ganem NJ, Cifuentes D, Wu CS, Dalal J, Lyons SM, Labadorf A, Flynn RL. SDE2 is an essential gene required for ribosome biogenesis and the regulation of alternative splicing. Nucleic Acids Res. 2021 09 20; 49(16):9424-9443. PMID: 34365507.

    Read at: PubMed

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