Shawn Lyons, PhD

Assistant Professor, Boston University Chobanian & Avedisian School of Medicine

Biography

Shawn Lyons obtained his Ph.D. in the laboratory of Dr. William Marzluff at UNC working on histone mRNA metabolism. He was a postdoctoral fellow with Dr. Paul Anderson at Harvard Medical School (Brigham and Women’s) and worked on the regulation of protein synthesis during acute stress response in cells, in particular how RNA metabolism and ribosome biogenesis are altered in response to stress.

Publications

  • Published 6/20/2025

    Kharel P, Bhatter N, Zubair S, Lyons SM, Anderson PJ, Ivanov P. G-quadruplex topologies determine the functional outcome of guanine-rich bioactive oligonucleotides. Nucleic Acids Res. 2025 Jun 20; 53(12). PMID: 40580035.

    Read at: PubMed

  • Published 12/1/2024

    Kharel P, Bhatter N, Zubair S, Lyons S, Anderson PJ, Ivanov P. G-quadruplex topologies determine the functional outcome of guanine-rich bioactive oligonucleotides. bioRxiv. 2024 Dec 01. PMID: 39651178.

    Read at: PubMed

  • Published 9/4/2024

    Bhatter N, Advani VM, Takenaka Y, Lyons SM, Akiyama Y, Anderson PJ, Ivanov P. Repurposing tRNA isodecoders for non-canonical functions via tRNA cleavage. bioRxiv. 2024 Sep 04. PMID: 39282440.

    Read at: PubMed

  • Published 8/6/2024

    Keiser PT, Zhang W, Ricca M, Wacquiez A, Grimins A, Cencic R, Patten JJ, Shah P, Padilha E, Connor JH, Pelletier J, Lyons SM, Saeed M, Brown LE, Porco JA, Davey RA. Amidino-rocaglates (ADRs), a class of synthetic rocaglates, are potent inhibitors of SARS-CoV-2 replication through inhibition of viral protein synthesis. Antiviral Res. 2024 Oct; 230:105976. PMID: 39117283.

    Read at: PubMed

  • Published 7/31/2024

    Gao Y, Kwan J, Orofino J, Burrone G, Mitra S, Fan TY, English J, Hekman R, Emili A, Lyons SM, Cardamone MD, Perissi V. Inhibition of K63 ubiquitination by G-Protein pathway suppressor 2 (GPS2) regulates mitochondria-associated translation. Pharmacol Res. 2024 Sep; 207:107336. PMID: 39094987.

    Read at: PubMed

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Websites

Education

  • University of North Carolina at Chapel Hill, PhD
  • New York University, MS
  • University of North Carolina at Chapel Hill, BS

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