Sharmila Masli, PhD

Associate Professor, Boston University Chobanian & Avedisian School of Medicine

Biography

The major focus of research in Dr. Masli's laboratory is the study of molecular mechanisms utilized by ocular antigen presenting cells (APCs) to regulate inflammatory ocular immune responses. Particular focus is on elucidating the role of thrombospondin-1 (TSP-1) in regulating ocular inflammation.

Her laboratory has identified spontaneous development of autoimmune Sjögren’s syndrome and related ocular inflammation in TSP-1 deficient mice that closely resembles clinical symptoms in human Sjögren’s patients. Different projects in the laboratory address immunologic mechanisms underlying disease development in these mice.

Publications

  • Published 1/23/2024

    Gordon RA, Nguyen Y, Foulquier N, Beydon M, Gheita TA, Hajji R, Sahbudin I, Hoi A, Ng WF, Mendonça JA, Wallace DJ, Shea B, Bruyn GA, Goodman SM, Fisher BA, Baldini C, Torralba KD, Bootsma H, Akpek EK, Karakus S, Baer AN, Chakravarty SD, Terslev L, D'Agostino MA, Mariette X, DiRenzo D, Rasmussen A, Papas A, Montoya C, Arends S, Yusof MYM, Pintilie I, Warner BM, Hammitt KM, Strand V, Bouillot C, Tugwell P, Inanc N, Andreu JL, Wahren-Herlenius M, Devauchelle-Pensec V, Shiboski CH, Benyoussef A, Masli S, Lee AYS, Cornec D, Bowman S, Rischmueller M, McCoy SS, Seror R. The Sjögren's Working Group: The 2023 OMERACT meeting and provisional domain generation. Semin Arthritis Rheum. 2024 Apr; 65:152378. PMID: 38310657.

    Read at: PubMed

  • Published 6/8/2022

    Masli S, Akpek EK. Reduced tear thrombospondin-1/matrix metalloproteinase-9 ratio can aid in detecting Sjögren's syndrome etiology in patients with dry eye. Clin Transl Sci. 2022 Aug; 15(8):1999-2009. PMID: 35610740.

    Read at: PubMed

  • Published 5/20/2022

    Soriano-Romaní L, Mir FA, Singh N, Chin I, Hafezi-Moghadam A, Masli S. CD47 Binding on Vascular Endothelial Cells Inhibits IL-17-Mediated Leukocyte Adhesion. Int J Mol Sci. 2022 May 20; 23(10). PMID: 35628515.

    Read at: PubMed

  • Published 8/9/2021

    Logeswaran A, Contreras-Ruiz L, Masli S. Conjunctival Goblet Cell Responses to TLR5 Engagement Promote Activation of Local Antigen-Presenting Cells. Front Immunol. 2021; 12:716939. PMID: 34434198.

    Read at: PubMed

  • Published 3/4/2021

    Simon LS, Keshav V, Baharozian C, Masli S, Lee HJ. Thrombospondin 1 polymorphism associated with decreased expression and increased risk of pterygium. Graefes Arch Clin Exp Ophthalmol. 2021 Aug; 259(8):2301-2307. PMID: 33661363.

    Read at: PubMed

View All 63 Publications:   View Full Profile in BUMC

Other Positions

  • Graduate Faculty (Primary Mentor of Grad Students)
    Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences

Websites

Education

  • Northeastern University, PhD
  • Northeastern University, MS
  • University of Bombay, BSc

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