Samuel Beck, PhD
Assistant Professor, Dermatology
Biography
As the volume of cumulated biological data grows exponentially, its systematic analyses and interpretations become more and more critical. However, the synergy between computational and experimental biology can be challenging due to the difficulty of clear communication between these disciplines. As an interdisciplinary biologist, my overarching career goal is to study crucial biological questions through the combination of Big Data analytics and experimental validations. Specifically, throughout my postdoctoral training and independent career, I have studied mammalian gene regulatory mechanisms at the transcription level. Through integrative and comprehensive Big Data analysis, I discovered that CpG islands (CGIs) direct modes of gene regulation, including 3-D chromatin architectures and transcriptional/epigenetic regulations. This discovery has provided important clues to the mechanism by which changes in chromatin architecture contribute to age-associated physiological deterioration.
Publications
- Published on 3/13/2024
Kim HJ, Batara DC, Jeon YJ, Lee S, Beck S, Kim SH. The impact of MEIS1 TALE homeodomain transcription factor knockdown on glioma stem cell growth. Anim Cells Syst (Seoul). 2024; 28(1):93-109. PMID: 38487309.
Read at: PubMed - Published on 3/21/2022
Lee J, Beck S. Misexpression of Genes Lacking Cpg Islands is a Hallmark of Aging. Open Access Journal of Gerontology & Geriatric Medicine. 2022; 3(6):OAJGGM.MS.ID.555690.
- Published on 12/15/2021
Lee JY, Davis I, Youth EHH, Kim J, Churchill G, Godwin J, Korstanje R, Beck S. Misexpression of genes lacking CpG islands drives degenerative changes during aging. Sci Adv. 2021 Dec 17; 7(51):eabj9111. PMID: 34910517.
Read at: PubMed - Published on 6/12/2021
Oh SH, Kim SH, Jeon JH, Kim EB, Lee NK, Beck S, Choi YJ, Kang SK. Cytoplasmic expression of a model antigen with M Cell-Targeting moiety in lactic acid bacteria and implication of the mechanism as a mucosal vaccine via oral route. Vaccine. 2021 Jul 05; 39(30):4072-4081. PMID: 34127296.
Read at: PubMed - Published on 3/18/2021
Lee JY, Song J, LeBlanc L, Davis I, Kim J, Beck S. Conserved dual-mode gene regulation programs in higher eukaryotes. Nucleic Acids Res. 2021 Mar 18; 49(5):2583-2597. PMID: 33621342.
Read at: PubMed - Published on 10/18/2019
Lee BK, Jang YJ, Kim M, LeBlanc L, Rhee C, Lee J, Beck S, Shen W, Kim J. Super-enhancer-guided mapping of regulatory networks controlling mouse trophoblast stem cells. Nat Commun. 2019 Oct 18; 10(1):4749. PMID: 31628347.
Read at: PubMed - Published on 4/1/2019
Skamagki M, Correia C, Yeung P, Baslan T, Beck S, Zhang C, Ross CA, Dang L, Liu Z, Giunta S, Chang TP, Wang J, Ananthanarayanan A, Bohndorf M, Bosbach B, Adjaye J, Funabiki H, Kim J, Lowe S, Collins JJ, Lu CW, Li H, Zhao R, Kim K. Author Correction: ZSCAN10 expression corrects the genomic instability of iPSCs from aged donors. Nat Cell Biol. 2019 Apr; 21(4):531-532. PMID: 30643186.
Read at: PubMed - Published on 8/3/2018
Wang E, Sorolla A, Cunningham PT, Bogdawa HM, Beck S, Golden E, Dewhurst RE, Florez L, Cruickshank MN, Hoffmann K, Hopkins RM, Kim J, Woo AJ, Watt PM, Blancafort P. Tumor penetrating peptides inhibiting MYC as a potent targeted therapeutic strategy for triple-negative breast cancers. Oncogene. 2019 Jan; 38(1):140-150. PMID: 30076412.
Read at: PubMed - Published on 5/18/2018
Beck S, Rhee C, Song J, Lee BK, LeBlanc L, Cannon L, Kim J. Implications of CpG islands on chromosomal architectures and modes of global gene regulation. Nucleic Acids Res. 2018 May 18; 46(9):4382-4391. PMID: 29529258.
Read at: PubMed - Published on 12/13/2017
Lee BK, Uprety N, Jang YJ, Tucker SK, Rhee C, LeBlanc L, Beck S, Kim J. Fosl1 overexpression directly activates trophoblast-specific gene expression programs in embryonic stem cells. Stem Cell Res. 2018 Jan; 26:95-102. PMID: 29272857.
Read at: PubMed
View 19 more publications: View full profile at BUMC