Samuel Beck, PhD

Assistant Professor, Boston University Chobanian & Avedisian School of Medicine

Biography

As the volume of cumulated biological data grows exponentially, its systematic analyses and interpretations become more and more critical. However, the synergy between computational and experimental biology can be challenging due to the difficulty of clear communication between these disciplines. As an interdisciplinary biologist, my overarching career goal is to study crucial biological questions through the combination of Big Data analytics and experimental validations. Specifically, throughout my postdoctoral training and independent career, I have studied mammalian gene regulatory mechanisms at the transcription level. Through integrative and comprehensive Big Data analysis, I discovered that CpG islands (CGIs) direct modes of gene regulation, including 3-D chromatin architectures and transcriptional/epigenetic regulations. This discovery has provided important clues to the mechanism by which changes in chromatin architecture contribute to age-associated physiological deterioration.

Publications

  • Published 2/12/2026

    Kim D, Byun S, Park J, Jang SJ, Kim Y, Yang SY, Kim M, Oh S, Lee J, Kim KB, Choi DK, Beck S, Lee JY. hStouffer: the enhanced meta-analysis method for the comprehensive analysis of large-scale RNA-seq data. BMC Bioinformatics. 2026 Feb 12; 27(1). PMID: 41680606.

    Read at: PubMed

  • Published 1/7/2026

    Kumar V, Beck S. Cellular insights into transposable elements in Alzheimer's disease. Front Mol Biosci. 2025; 12:1642599. PMID: 41573740.

    Read at: PubMed

  • Published 12/4/2025

    Ma J, Kim N, Cha JH, Kim W, Kim CY, Lee YH, Kim HS, Han YD, Yong D, Han E, Yang S, Beck S, Lee I. A human gut metagenome-assembled genome catalogue spanning 41 countries supports genome-scale metabolic models. Nat Microbiol. 2026 Jan; 11(1):317-334. PMID: 41345261.

    Read at: PubMed

  • Published 10/29/2025

    Cha JH, Kim N, Ma J, Lee S, Koh G, Yang S, Beck S, Byeon I, Lee B, Lee I. A high-quality genomic catalog of the human oral microbiome broadens its phylogeny and clinical insights. Cell Host Microbe. 2025 Nov 12; 33(11):1977-1994.e8. PMID: 41167188.

    Read at: PubMed

  • Published 7/25/2025

    Kabir TD, Beck S, Stuart LM, Li J, Hou R, Liu P, Margolius S, Kim C, Choi YS, Bastow ER, Beveridge DJ, Spalding L, Li Z, Ginhoux F, Chow P, Phillips M, Redfern AD, Yeoh GC, Forrest A, Woo AJ, Sharma A, George J, McCaughan G, Leedman PJ. Inhibition of the Caveolin-1 pathway promotes apoptosis and overcomes pan-tyrosine kinase inhibitor resistance in hepatocellular carcinoma. Cell Death Dis. 2025 Jul 25; 16(1):561. PMID: 40715090.

    Read at: PubMed

View All 41 Publications:   View Full Profile in BUMC

Websites

Education

  • Seoul National University, PhD
  • Seoul National University, BS

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