Samuel Beck, PhD
Assistant Professor, Dermatology
Biography
As the volume of cumulated biological data grows exponentially, its systematic analyses and interpretations become more and more critical. However, the synergy between computational and experimental biology can be challenging due to the difficulty of clear communication between these disciplines. As an interdisciplinary biologist, my overarching career goal is to study crucial biological questions through the combination of Big Data analytics and experimental validations. Specifically, throughout my postdoctoral training and independent career, I have studied mammalian gene regulatory mechanisms at the transcription level. Through integrative and comprehensive Big Data analysis, I discovered that CpG islands (CGIs) direct modes of gene regulation, including 3-D chromatin architectures and transcriptional/epigenetic regulations. This discovery has provided important clues to the mechanism by which changes in chromatin architecture contribute to age-associated physiological deterioration.
Publications
- Published on 12/4/2024
Seo H, Kim S, Beck S, Song HY. Perspectives on Microbiome Therapeutics in Infectious Diseases: A Comprehensive Approach Beyond Immunology and Microbiology. Cells. 2024 Dec 04; 13(23). PMID: 39682751.
Read at: PubMed - Published on 12/3/2024
Gladyshev VN, Anderson B, Barlit H, Barré B, Beck S, Behrouz B, Belsky DW, Chaix A, Chamoli M, Chen BH, Cheng K, Chuprin J, Churchill GA, Cipriano A, Colville A, Deelen J, Deigin Y, Edmonds KK, English BW, Fang R, Florea M, Gershteyn IM, Gill D, Goetz LH, Gorbunova V, Griffin PT, Horvath S, Borch Jensen M, Jin X, Jovanovska S, Kajderowicz KM, Kasahara T, Kerepesi C, Kulkarni S, Labunskyy VM, Levine ME, Libert S, Lu JY, Lu YR, Marioni RE, McCoy BM, Mitchell W, Moqri M, Nasirian F, Niimi P, Oh HS, Okundaye B, Parkhitko AA, Peshkin L, Petljak M, Poganik JR, Pridham G, Promislow DEL, Prusisz W, Quiniou M, Raj K, Richard D, Ricon JL, Rutledge J, Scheibye-Knudsen M, Schork NJ, Seluanov A, Shadpour M, Shindyapina AV, Shuken SR, Sivakumar S, Stoeger T, Sugiura A, Sutton NR, Suvorov A, Tarkhov AE, Teeling EC, Trapp A, Tyshkovskiy A, Unfried M, Ward-Caviness CK, Yim SH, Ying K, Yunes J, Zhang B, Zhavoronkov A. Disagreement on foundational principles of biological aging. PNAS Nexus. 2024 Dec; 3(12):pgae499. PMID: 39660064.
Read at: PubMed - Published on 10/18/2024
Kumar V, Beck S. Single-cell multimodal chromatin profiles revealing epigenetic regulations of cells in hepatocellular carcinoma. Clin Transl Discov. 2024 Oct; 4(5). PMID: 39444758.
Read at: PubMed - Published on 9/27/2024
Batara DC, Kim HJ, Phan LT, Kim M, Son YO, Lee S, Park SI, Choi YS, Beck S, Kim SH. Elevated a-1,2-mannosidase MAN1C1 in glioma stem cells and its implications for immunological changes and prognosis in glioma patients. Sci Rep. 2024 Sep 27; 14(1):22159. PMID: 39333557.
Read at: PubMed - Published on 7/4/2024
Lee K, Barone M, Waterbury AL, Jiang H, Nam E, DuBois-Coyne SE, Whedon SD, Wang ZA, Caroli J, Neal K, Ibeabuchi B, Dhoondia Z, Kuroda MI, Liau BB, Beck S, Mattevi A, Cole PA. Uncoupling histone modification crosstalk by engineering lysine demethylase LSD1. Nat Chem Biol. 2025 Feb; 21(2):227-237. PMID: 38965385.
Read at: PubMed - Published on 3/13/2024
Kim HJ, Batara DC, Jeon YJ, Lee S, Beck S, Kim SH. The impact of MEIS1 TALE homeodomain transcription factor knockdown on glioma stem cell growth. Anim Cells Syst (Seoul). 2024; 28(1):93-109. PMID: 38487309.
Read at: PubMed - Published on 2/1/2024
Wu M, Hanly A, Gibson F, Fisher R, Rogers S, Park K, Zuger A, Kuang K, Kalin JH, Nocco S, Cole M, Xiao A, Agus F, Labadorf A, Beck S, Collard M, Cole PA, Alani RM. The CoREST repressor complex mediates phenotype switching and therapy resistance in melanoma. J Clin Invest. 2024 Feb 01; 134(6). PMID: 38300709.
Read at: PubMed - Published on 11/29/2023
Crossland NA, Beck S, Tan WY, Lo M, Mason JB, Zhang C, Guo W, Crott JW. Fecal microbiota transplanted from old mice promotes more colonic inflammation, proliferation, and tumor formation in azoxymethane-treated A/J mice than microbiota originating from young mice. Gut Microbes. 2023 Dec; 15(2):2288187. PMID: 38031252.
Read at: PubMed - Published on 3/21/2022
Lee J, Beck S. Misexpression of Genes Lacking Cpg Islands is a Hallmark of Aging. Open Access Journal of Gerontology & Geriatric Medicine. 2022; 3(6):OAJGGM.MS.ID.555690.
- Published on 12/15/2021
Lee JY, Davis I, Youth EHH, Kim J, Churchill G, Godwin J, Korstanje R, Beck S. Misexpression of genes lacking CpG islands drives degenerative changes during aging. Sci Adv. 2021 Dec 17; 7(51):eabj9111. PMID: 34910517.
Read at: PubMed
View 26 more publications: View full profile at BUMC