S. Reza Jafarzadeh, DVM, MPVM, PhD

Associate Professor, Medicine

S. Reza Jafarzadeh
617.358.9665
650 Albany Street, Suite X200

Biography

I am interested in the application of causal inference methods in observational studies, especially in the setting of longitudinal data, where time-varying exposures, time-dependent confounding, and selection bias are often present. In particular, I am interested in the application of the variety of modern analytical techniques for estimating causal effects as well as the concepts such as direct and indirect effect decomposition (causal mediation analysis), causal interactions and sufficient causes, and causal interference and spill-over effects. These analytical techniques can be applied to broad areas of health sciences research, but I am particularly interested in the application of causal inference for comparative effectiveness research and implementation science. The methods are very useful for the development and assessment of strategies to improve population health using non-experimental data.

I am also interested in the application of Bayesian methods for evaluation of diagnostic tests and prevalence estimation in the absence of a perfect reference standard. These methods have broad applications in diagnosis and screening, and can be used to estimate true prevalence using imperfect tests.

Other Positions

  • Member, Arthritis & Autoimmune Diseases Research Center, Boston University

Education

  • University of Tehran, DVM
  • University of California, Davis, MPVM
  • University of California, Davis, PhD

Publications

  • Published on 3/24/2024

    Bacon KL, Felson DT, Jafarzadeh SR, Kolachalama VB, Hausdorff JM, Gazit E, Stefanik JJ, Corrigan P, Segal NA, Lewis CE, Nevitt MC, Kumar D. Gait Alterations and Association With Worsening Knee Pain and Physical Function: A Machine Learning Approach With Wearable Sensors in the Multicenter Osteoarthritis Study. Arthritis Care Res (Hoboken). 2024 Mar 24. PMID: 38523250.

    Read at: PubMed
  • Published on 3/22/2024

    Bosch NA, Law AC, Shi Z, Jafarzadeh SR, Walkey AJ. A novel measure to summarize blood transfusion practice during critical illness. Transfusion. 2024 May; 64(5):784-788. PMID: 38515390.

    Read at: PubMed
  • Published on 1/1/2024

    Bosch NA, Myers LC, Jafarzadeh SR, Wunsch H, Stevens JP, Liu VX, Walkey AJ. Temporal Trends in Use of Opioids for Patients with Acute Respiratory Failure following "Analgesia-First" Sedation Guidelines. Ann Am Thorac Soc. 2024 Jan; 21(1):179-183. PMID: 37847821.

    Read at: PubMed
  • Published on 12/28/2023

    Aoyagi K, Jafarzadeh SR, Carlesso L, Frey Law L, Lewis CE, Nevitt M, Neogi T. Mediating Effect of Pain Sensitization on the Paradoxical Relation of Taking Opioids to Pain Severity in Knee Osteoarthritis: The Multicenter Osteoarthritis Study. Arthritis Care Res (Hoboken). 2024 Mar; 76(3):403-408. PMID: 37750238.

    Read at: PubMed
  • Published on 10/15/2023

    Liew JW, Jarraya M, Guermazi A, Lynch J, Wang N, Rabasa G, Jafarzadeh SR, Nevitt M, Torner J, Lewis CE, Felson DT, Neogi T. Relation of Intra-Articular Mineralization to Knee Pain in Knee Osteoarthritis: A Longitudinal Analysis in the MOST Study. Arthritis Rheumatol. 2023 Dec; 75(12):2161-2168. PMID: 37410792.

    Read at: PubMed
  • Published on 5/1/2023

    Bosch NA, Teja B, Law AC, Pang B, Jafarzadeh SR, Walkey AJ. Comparative Effectiveness of Fludrocortisone and Hydrocortisone vs Hydrocortisone Alone Among Patients With Septic Shock. JAMA Intern Med. 2023 May 01; 183(5):451-459. PMID: 36972033.

    Read at: PubMed
  • Published on 3/31/2023

    Corrigan P, Neogi T, Frey-Law L, Jafarzadeh SR, Segal N, Nevitt MC, Lewis CE, Stefanik JJ. Relation of pain sensitization to self-reported and performance-based measures of physical functioning: the Multicenter Osteoarthritis (MOST) study. Osteoarthritis Cartilage. 2023 Jul; 31(7):966-975. PMID: 37003421.

    Read at: PubMed
  • Published on 3/3/2023

    Costello KE, Felson DT, Jafarzadeh SR, Guermazi A, Roemer FW, Segal NA, Lewis CE, Nevitt MC, Lewis CL, Kolachalama VB, Kumar D. Gait, physical activity and tibiofemoral cartilage damage: a longitudinal machine learning analysis in the Multicenter Osteoarthritis Study. Br J Sports Med. 2023 Aug; 57(16):1018-1024. PMID: 36868795.

    Read at: PubMed
  • Published on 12/23/2022

    Bacon KL, Felson DT, Jafarzadeh SR, Kolachalama VB, Hausdorff JM, Gazit E, Segal NA, Lewis CE, Nevitt MC, Kumar D. Relation of gait measures with mild unilateral knee pain during walking using machine learning. Sci Rep. 2022 Dec 23; 12(1):22200. PMID: 36564397.

    Read at: PubMed
  • Published on 10/15/2022

    Riddle DL, Reza Jafarzadeh S. Effects of psychological distress on the general health to self-reported pain and function outcome relationship in knee arthroplasty: A causal mediation study. Osteoarthr Cartil Open. 2022 Dec; 4(4):100315. PMID: 36474788.

    Read at: PubMed

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