Robert A. Stern, PhD

Professor, Boston University Chobanian & Avedisian School of Medicine

Biography

Dr. Robert Stern is Professor of Neurology, Neurosurgery, and Anatomy & Neurobiology at Boston University (BU) Chobanian & Avedisian School of Medicine. He is an internationally recognized expert on the neurodegenerative disease, chronic traumatic encephalopathy (CTE), and is Co-Founder and Director of Clinical Research for the BU CTE Center. From 2010-2019, he was the Director of the Clinical Core of the BU Alzheimer’s Disease Research Center (funded by U.S. National Institutes of Health, NIH). The focus of Dr. Stern’s research is to develop methods of detecting and diagnosing CTE during life and to better understand the risk factors for later-life neurological consequences of repetitive mild traumatic brain injuries in former American football players, soccer players, and other contact sport athletes. He was the principal investigator of the first grant funded by NIH to study CTE, for the DETECT Study. Subsequently, he was the lead investigator of the DIAGNOSE CTE Research Project, a NIH-funded, multi-center, 8-year study (2015-2023) to develop methods of detecting and diagnosing CTE during life, including the development and examination of neuroimaging and fluid biomarkers, establishing and validating diagnostic criteria for Traumatic Encephalopathy Syndrome (TES), and studying potential risk factors of the disease. He is currently one of the principal investigators for the DIAGNOSE CTE Research Project-II, a NIH-funded multi-center study expanding upon the original DIAGNOSE study, examining new potential blood and imaging biomarkers to diagnose CTE in living patients and differentiate CTE from similar diseases, such as Alzheimer’s disease (AD). Dr. Stern was also the principal investigator (currently co-investigator) of the Head Impact & Trauma Surveillance Study (HITSS; also funded by NIH), a longitudinal online assessment of over 6000 former American football players and soccer players (age 40 years or older), who participated at any level. Dr. Stern’s other major area of funded research includes the diagnosis and treatment of AD. He has had continuous research funding for over 35 years, from NIH, the U.S. Department of Defense, foundations, and industry. Dr. Stern was a member of the NFL Players Association’s Mackey-White Player Health and Safety Committee as well as the court-appointed Medical Science Committee of the NCAA Concussion Settlement. He has over 250 peer-reviewed publications, has been a member of several medical journal editorial boards, and is the co-editor of two books: Sports Neurology, part of the Handbook of Clinical Neurology series; and the Oxford Handbook of Adult Cognitive Disorders. He is a licensed clinical neuropsychologist and has developed several widely used neuropsychological tests, including the Neuropsychological Assessment Battery (NAB). He is a Fellow of the American Neuropsychiatric Association and the National Academy of Neuropsychology. Throughout his career Dr. Stern has received several honors and recently was awarded the 2025 Leon Thal Prize in Recognition of Research Excellence by the Cleveland Clinic Lou Ruvo Center for Brain Health.

Publications

  • Published 4/21/2025

    van Amerongen S, Peskind ER, Tripodis Y, Adler CH, Balcer LJ, Bernick C, Alosco ML, Katz D, Banks SJ, Barr WB, Cantu RC, Dodick DW, Geda YE, Mez J, Wethe JV, Weller JL, Daneshvar DH, Palmisano J, Fagle T, Holleck M, Kossow B, Pulukuri S, Tuz-Zahra F, Colasurdo E, Sikkema C, Iliff J, Li G, Shenton ME, Reiman EM, Cummings JL, Stern RA. Catecholamine Dysregulation in Former American Football Players: Findings From the DIAGNOSE CTE Research Project. Neurology. 2025 May 27; 104(10):e213584. PMID: 40258206.

    Read at: PubMed

  • Published 4/15/2025

    Han X, Zhang Y, Petrosky JN, Bald S, Sherva RM, Labadorf A, Cherry JD, Chung J, Farrell K, Abdolmohammadi B, Durape S, Martin BM, Palmisano JN, Farrell JJ, Alvarez VE, Huber BR, Dwyer B, Daneshvar DH, Dams-O'Connor K, Jun GR, Lunetta KL, Goldstein LE, Katz DI, Cantu RC, Shenton ME, Cummings JL, Reiman EM, Stern RA, Alosco ML, Tripodis Y, Farrer LA, Stein TD, Crary JF, McKee AC, Mez J. A structural haplotype in the 17q21.31 MAPT region is associated with increased risk for chronic traumatic encephalopathy endophenotypes. Cell Rep Med. 2025 May 20; 6(5):102084. PMID: 40239644.

    Read at: PubMed

  • Published 3/28/2025

    Labonte J, Sugarman MA, Pettway E, Zetterberg H, Blennow K, Ashton NJ, Karikari TK, Aparicio HJ, Frank B, Tripodis Y, Martin B, Palmisano JN, Steinberg EG, Simkin I, Farrer LA, Jun GR, Turk KW, Budson AE, O'Connor MK, Au R, Goldstein LE, Stern RA, Stein TD, McKee AC, Qiu WQ, Mez J, Banks SJ, Alosco ML. Sex differences on tau, astrocytic, and neurodegenerative plasma biomarkers. J Alzheimers Dis. 2025 May; 105(2):443-452. PMID: 40151917.

    Read at: PubMed

  • Published 3/6/2025

    Emrani S, Koutures A, Tripodis Y, Uretsky M, Abdolmohammadi B, Nowinski C, Daneshvar DH, Dwyer B, Katz DI, Goldstein LE, Cantu RC, Martin BM, Palmisano JN, Dams-O'Connor K, Crary JF, Stern RA, Mez J, Alvarez VE, Huber BR, McKee AC, Stein TD, Alosco ML. Characterizing white matter and vascular pathologies in brain donors exposed to repetitive head impacts. Acta Neuropathol. 2025 Mar 06; 149(1):24. PMID: 40047953.

    Read at: PubMed

  • Published 3/1/2025

    Miner AE, Groh JR, Farris C, Hattiangadi S, Cui A, Brickman AM, Alshikho M, Rabinovici GD, Rosen HJ, Cobigo Y, Asken B, Nowinski CJ, Bureau S, Shahrokhi F, Tripodis Y, Ly M, Altaras C, Lenio S, Stern RA, Rosen G, Kelley H, Huber BR, Stein TD, Mez J, McKee AC, Alosco ML. Does white matter and vascular injury from repetitive head impacts lead to a novel pattern on T2 FLAIR MRI? A hypothesis proposal and call for research. Alzheimers Dement. 2025 Mar; 21(3):e70085. PMID: 40145364.

    Read at: PubMed

Other Positions

  • Professor, Anatomy & Neurobiology
    Boston University Chobanian & Avedisian School of Medicine
  • Professor, Neurosurgery
    Boston University Chobanian & Avedisian School of Medicine
  • Graduate Faculty (Primary Mentor of Grad Students)
    Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences
  • Director of Clinical Research, Chronic Traumatic Encephalopathy Center
    Boston University Chobanian & Avedisian School of Medicine

Education

  • University of Rhode Island, PhD
  • University of Rhode Island, MA
  • Wesleyan University, BA