Robert A. Lafyatis, MD

Adjunct Professor, Boston University Chobanian & Avedisian School of Medicine

Biography

Dr. Lafyatis carries out patient oriented research into the cause and treatment of systemic sclerosis. This includes early phase clinical trials into new therapeutic agents in patients with systemic sclerosis. He has been investigating the mechanisms of actions and markers of response for novel therapeutics, such as the B cell depleting agent, rituximab and the immunosuppressant agent, mycophenlate. Additional studies are aimed at identifying biomarkers in systemic sclerosis using microarray gene expression analysis of skin and blood in scleroderma patients. Ongoing biomarker studies include investigation into molecular markers of pulmonary hypertension in systemic sclerosis. Dr. Lafyatis also carries out basic research into the cause of fibrosis and vasculopathy in systemic sclerosis using patient samples and murine disease models. His studies have provided key insights into one widely used model of systemic sclerosis, the tight skin mouse. His studies are currently focused on understanding how autoimmunity and the innate immune system lead to fibrosis and vascular damage. This has recently led to the discovery of increased interferon-regulated gene expression in white blood cells of patients with systemic sclerosis. Ongoing research is aimed at better understanding the cause of altered gene expression by monocytes and other cells in the innate immune system.

Publications

  • Published 4/30/2026

    Trbojevic S, Dong X, Lafyatis R, Gold MS, Taboas JM, Almarza AJ. Single-cell RNA sequencing of healthy and diseased rat temporomandibular joint condyle cartilage. PLoS One. 2026; 21(4):e0348175. PMID: 42060618.

    Read at: PubMed

  • Published 4/10/2026

    Hasanaj E, Beaulieu D, Wang C, Hu Q, Rosas L, Bueno M, Sembrat JC, Pineda RH, Melo-Narvaez MC, Cardenes N, Yanwu Z, Yingze Z, Lafyatis R, Morris A, Mora A, Rojas M, Li D, Rahman I, Pryhuber GS, Lehmann M, Alder J, Gurkar A, Finkel T, Ma Q, Lugo-Martinez J, Póczos B, Bar-Joseph Z, Eickelberg O, Königshoff M. SenSet defines cell-type specific senescence signatures in the aged human lung. EMBO J. 2026 May; 45(10):3589-3638. PMID: 41963555.

    Read at: PubMed

  • Published 2/6/2026

    Sideris D, Lee H, Olson L, Nallaparaju K, Okuyama K, Ciavarri J, Lafyatis R, Larsen M, Lin B, Alfaras I, Kennerdell J, Finkel T, Liu Y, Chen B, Lyu L. Suppression of interferon signaling via small-molecule modulation of TFAM. Elife. 2026 Feb 06; 14. PMID: 41649246.

    Read at: PubMed

  • Published 2/4/2026

    Kaundal U, Tsou PS, Sahu M, Huang M, Boyden SE, Woodford CM, Shriner D, Stenson E, Safran SA, Zhou Y, Talley TA, Gudapati K, Zhang X, Kunishita Y, Wang J, Shah AA, Mayes MD, Doumatey AP, Bentley AR, Domsic R, Medsger TA, Ramos PS, Silver RM, Steen V, Varga J, Hsu V, Saketkoo LA, Schiopu E, Gordon JK, Criswell LA, Gladue H, Derk C, Bernstein EJ, Bridges SL, Shanmugam V, Chung L, Kafaja S, Jan R, Trojanowski M, Goldberg A, Korman BD, Mullikin J, Thomas JW, Dell'Orso S, Randazzo D, Adeyemo A, Remmers EF, Schwartzberg PL, Aksentijevich I, Rotimi C, Wigley FM, Wang RA, Boin F, Khanna D, Lafyatis R, Kastner DL, Gourh P. Gain of function NOTCH4 variants disrupt angiogenesis in systemic sclerosis. Ann Rheum Dis. 2026 Feb 04. PMID: 41644364.

    Read at: PubMed

  • Published 1/29/2026

    Padilla CM, Lafyatis R, Gibson KF, Morse C, Valenzi E, Chen X, Li X, Zhao Y, Park Y, Ascherman D, Minden J, Domsic R, Zhang Y, Kass DJ. Monocyte LOXHD1 and RHOB Expression Predictive of Progressive Systemic Sclerosis-Associated Interstitial Lung Disease. Arthritis Care Res (Hoboken). 2026 Apr; 78(4):456-468. PMID: 40771159.

    Read at: PubMed

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Other Positions

  • Member, Evans Center for Interdisciplinary Biomedical Research
    Boston University

Websites

Education

  • University of Cincinnati, MD
  • Massachusetts Institute of Technology, BS

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