Ricardo Henrique da Costa e Sousa, DVM, MS, DSc

Assistant Professor, Medicine



Dr. Ricardo da Costa e Sousa has a broad background in Physiology and Basic Medical Research, with special expertise in Neuroendocrinology. During his Doctorate he has studied how the hypothalamus controls TSH secretion and thyroid activity, focusing on the role of NPY receptors. He further deepened his research on the hypothalamic-pituitary-axis during his postdoc, studying thyroid hormones action in the pituitary and the regulation of TRH neurons. His research has contributed to our current understanding of how the brain controls the thyroid as well as how thyroid hormones acts in different tissues.

In 2019, he joined the Division of Endocrinology, Diabetes and Metabolism at Weill Cornell Medicine to study how specific subpopulations of hypothalamic neurons control the HPT axis, as well as how thyroid hormones act in the hypothalamus. Recent data his team generated is promising and has the potential to change paradigms in the field. He became an Assistant Professor at Boston University in 2022. Currently, his research interest is focused on the neuroendocrine control of thyroid hormones and metabolism.


  • Published on 6/6/2023

    Costa-E-Sousa RH, Rorato R, Hollenberg AN, Vella KR. Regulation of Thyroid Hormone Levels by Hypothalamic Thyrotropin-Releasing Hormone Neurons. Thyroid. 2023 Jul; 33(7):867-876. PMID: 37166378.

    Read at: PubMed
  • Published on 12/1/2015

    Calvino C, Império GE, Wilieman M, Costa-E-Sousa RH, Souza LL, Trevenzoli IH, Pazos-Moura CC. Hypothyroidism Induces Hypophagia Associated with Alterations in Protein Expression of Neuropeptide Y and Proopiomelanocortin in the Arcuate Nucleus, Independently of Hypothalamic Nuclei-Specific Changes in Leptin Signaling. Thyroid. 2016 Jan; 26(1):134-43. PMID: 26538454.

    Read at: PubMed
  • Published on 4/8/2014

    Astapova I, Ramadoss P, Costa-e-Sousa RH, Ye F, Holtz KA, Li Y, Niepel MW, Cohen DE, Hollenberg AN. Hepatic nuclear corepressor 1 regulates cholesterol absorption through a TRß1-governed pathway. J Clin Invest. 2014 May; 124(5):1976-86. PMID: 24713658.

    Read at: PubMed
  • Published on 2/18/2014

    Vella KR, Ramadoss P, Costa-E-Sousa RH, Astapova I, Ye FD, Holtz KA, Harris JC, Hollenberg AN. Thyroid hormone signaling in vivo requires a balance between coactivators and corepressors. Mol Cell Biol. 2014 May; 34(9):1564-75. PMID: 24550004.

    Read at: PubMed
  • Published on 11/27/2013

    Ramadoss P, Abraham BJ, Tsai L, Zhou Y, Costa-e-Sousa RH, Ye F, Bilban M, Zhao K, Hollenberg AN. Novel mechanism of positive versus negative regulation by thyroid hormone receptor ß1 (TRß1) identified by genome-wide profiling of binding sites in mouse liver. J Biol Chem. 2014 Jan 17; 289(3):1313-28. PMID: 24288132.

    Read at: PubMed
  • Published on 8/9/2012

    Costa-e-Sousa RH, Astapova I, Ye F, Wondisford FE, Hollenberg AN. The thyroid axis is regulated by NCoR1 via its actions in the pituitary. Endocrinology. 2012 Oct; 153(10):5049-57. PMID: 22878400.

    Read at: PubMed
  • Published on 8/8/2012

    Calvino C, Souza LL, Costa-e-Sousa RH, Almeida NA, Trevenzoli IH, Pazos-Moura CC. Hypothyroidism reduces ObRb-STAT3 leptin signalling in the hypothalamus and pituitary of rats associated with resistance to leptin acute anorectic action. J Endocrinol. 2012 Oct; 215(1):129-35. PMID: 22875962.

    Read at: PubMed
  • Published on 7/3/2012

    Costa-e-Sousa RH, Hollenberg AN. Minireview: The neural regulation of the hypothalamic-pituitary-thyroid axis. Endocrinology. 2012 Sep; 153(9):4128-35. PMID: 22759379.

    Read at: PubMed
  • Published on 2/2/2012

    Fidelis-de-Oliveira P, Werneck-de-Castro JP, Pinho-Ribeiro V, Shalom BC, Nascimento-Silva JH, Costa e Souza RH, Cruz IS, Rangel RR, Goldenberg RC, Campos-de-Carvalho AC. Soluble factors from multipotent mesenchymal stromal cells have antinecrotic effect on cardiomyocytes in vitro and improve cardiac function in infarcted rat hearts. Cell Transplant. 2012; 21(5):1011-21. PMID: 22305373.

    Read at: PubMed
  • Published on 7/21/2011

    Costa-e-Sousa RH, Souza LL, Calviño C, Cabanelas A, Almeida NA, Oliveira KJ, Pazos-Moura CC. Central NPY-Y5 receptors activation plays a major role in fasting-induced pituitary-thyroid axis suppression in adult rat. Regul Pept. 2011 Nov 10; 171(1-3):43-7. PMID: 21771616.

    Read at: PubMed

View 21 more publications: View full profile at BUMC

View all profiles