Raphael A. Zoeller, PhD

Associate Professor, Boston University Chobanian & Avedisian School of Medicine

Biography

My expertise is in the area of lipid biosynthesis and metabolism and how they relate to human disease. My laboratory uses molecular biology, lipid chemistry & analysis, protein chemistry and forward genetics (mutant isolation).
We have recently developed a cell-based, high-throughput protocol to screen small molecule libraries for inhibitors of animal cell phospholipid biosynthesis. We have identified several candidate compounds and are now characterizing their efficacy and mode(s) of action.

Publications

  • Published 5/10/2022

    Shakya S, Herr RA, Carlson HL, Zoeller RA, Albert CJ, Ford DA. Endothelial Cell Protein Targeting by Myeloperoxidase-Derived 2-Chlorofatty Aldehyde. Antioxidants (Basel). 2022 May 10; 11(5). PMID: 35624804.

    Read at: PubMed

  • Published 9/11/2020

    Honsho M, Tanaka M, Zoeller RA, Fujiki Y. Distinct Functions of Acyl/Alkyl Dihydroxyacetonephosphate Reductase in Peroxisomes and Endoplasmic Reticulum. Front Cell Dev Biol. 2020; 8:855. PMID: 33042986.

    Read at: PubMed

  • Published 3/24/2020

    Werner ER, Keller MA, Sailer S, Lackner K, Koch J, Hermann M, Coassin S, Golderer G, Werner-Felmayer G, Zoeller RA, Hulo N, Berger J, Watschinger K. The TMEM189 gene encodes plasmanylethanolamine desaturase which introduces the characteristic vinyl ether double bond into plasmalogens. Proc Natl Acad Sci U S A. 2020 04 07; 117(14):7792-7798. PMID: 32209662.

    Read at: PubMed

  • Published 1/3/2020

    Park H, Haller J, Smith F, Parkin N, Lythe T, Zoeller RA, Chakravorty S. Attenuation of Hemolysis Due to Glucose-6-Phosphate Isomerase Deficiency With Ketogenic Diet - A Case Report. Hemasphere. 2020 Feb; 4(1):e328. PMID: 32072144.

    Read at: PubMed

  • Published 3/6/2019

    Zoeller RA, Geoghegan-Barek K. A cell-based high-throughput screen identifies tyrphostin AG 879 as an inhibitor of animal cell phospholipid and fatty acid biosynthesis. Biochem Biophys Rep. 2019 Jul; 18:100621. PMID: 30899803.

    Read at: PubMed

View All 42 Publications:   View Full Profile in BUMC

Other Positions

  • Research Assistant Professor, Medicine
    Boston University Chobanian & Avedisian School of Medicine
  • Graduate Faculty (Primary Mentor of Grad Students)
    Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences
  • Member, Boston Nutrition Obesity Research Center
    Boston University

Websites

Education

  • Texas A&M University, PhD
  • University of Maine, BS

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