Prajna Guha, PhD

Assistant Professor, Surgery

Prajna Guha
617.358.7492
72 E. Concord Street

Education

  • St John's University, PhD
  • Northeastern University, MS
  • Jadavpur University, BS

Publications

  • Published on 6/15/2022

    Sullivan KM, Jiang X, Guha P, Lausted C, Carter JA, Hsu C, Labadie KP, Kohli K, Kenerson HL, Daniel SK, Yan X, Meng C, Abbasi A, Chan M, Seo YD, Park JO, Crispe IN, Yeung RS, Kim TS, Gujral TS, Tian Q, Katz SC, Pillarisetty VG. Blockade of interleukin 10 potentiates antitumour immune function in human colorectal cancer liver metastases. Gut. 2023 Feb; 72(2):325-337. PMID: 35705369.

    Read at: PubMed
  • Published on 6/14/2022

    Ghosh CC, Heatherton KR, Connell KPO, Alexander IS, Greer DA, LaPorte J, Guha P, Cox BF, Katz SC. Regional infusion of a class C TLR9 agonist enhances liver tumor microenvironment reprogramming and MDSC reduction to improve responsiveness to systemic checkpoint inhibition. Cancer Gene Ther. 2022 Dec; 29(12):1854-1865. PMID: 35697801.

    Read at: PubMed
  • Published on 3/11/2022

    Guha P, Heatherton KR, O'Connell KP, Alexander IS, Katz SC. Assessing the Future of Solid Tumor Immunotherapy. Biomedicines. 2022 Mar 11; 10(3). PMID: 35327456.

    Read at: PubMed
  • Published on 12/17/2021

    Chai LF, Hardaway JC, Heatherton KR, O'Connell KP, LaPorte JP, Guha P, Lopes MC, Rabinowitz BA, Jaroch D, Cox BF, Knight R, Katz SC. Antigen Receptor T Cells (CAR-T) Effectively Control Tumor Growth in a Colorectal Liver Metastasis Model. J Surg Res. 2022 04; 272:37-50. PMID: 34929499.

    Read at: PubMed
  • Published on 12/13/2021

    Guha P, Katz SC. Strategies for manufacturing cell therapy products aligned with patient needs. Methods Cell Biol. 2022; 167:203-226. PMID: 35152997.

    Read at: PubMed
  • Published on 9/4/2021

    DaSilva NA, Barlock BJ, Guha P, Ghosh CC, Trebino CE, Camberg JL, Katz SC, Rowley DC. Proteomic signatures of myeloid derived suppressor cells from liver and lung metastases reveal functional divergence and potential therapeutic targets. Cell Death Discov. 2021 Sep 04; 7(1):232. PMID: 34482371.

    Read at: PubMed
  • Published on 7/21/2021

    Chai LF, Hardaway JC, Heatherton KR, O'Connell KP, Lopes MC, Rabinowitz BA, Ghosh CC, Guha P, Jaroch D, Cox BF, Katz SC. Regional Delivery of Anti-PD-1 Agent for Colorectal Liver Metastases Improves Therapeutic Index and Anti-Tumor Activity. Vaccines (Basel). 2021 Jul 21; 9(8). PMID: 34451932.

    Read at: PubMed
  • Published on 11/23/2020

    Guha P, Gardell J, Rabinowitz B, Lopes M, DaSilva NA, Rowley D, Katz SC. Monocytic and granulocytic myeloid-derived suppressor cell plasticity and differentiation are organ-specific. Oncogene. 2021 01; 40(3):693-704. PMID: 33230244.

    Read at: PubMed
  • Published on 8/1/2020

    Katz SC, Moody AE, Guha P, Hardaway JC, Prince E, LaPorte J, Stancu M, Slansky JE, Jordan KR, Schulick RD, Knight R, Saied A, Armenio V, Junghans RP. HITM-SURE: Hepatic immunotherapy for metastases phase Ib anti-CEA CAR-T study utilizing pressure enabled drug delivery. J Immunother Cancer. 2020 08; 8(2). PMID: 32843493.

    Read at: PubMed
  • Published on 6/3/2019

    Katz SC, Hardaway J, Prince E, Guha P, Cunetta M, Moody A, Wang LJ, Armenio V, Espat NJ, Junghans RP. HITM-SIR: phase Ib trial of intraarterial chimeric antigen receptor T-cell therapy and selective internal radiation therapy for CEA+ liver metastases. Cancer Gene Ther. 2020 05; 27(5):341-355. PMID: 31155611.

    Read at: PubMed

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