Paul Maglione, MD, PhD

Assistant Professor, Boston University Chobanian & Avedisian School of Medicine

Biography

Background:
Paul J. (PJ) Maglione, MD, PhD is an Assistant Professor of Medicine in the Section of Pulmonary, Allergy, Sleep & Critical Care Medicine at the Chobanian and Avedisian School of Medicine. He is a physician-scientist with expertise in the clinical care of primary immunodeficiencies and runs a laboratory in the Pulmonary Center at the Boston University Medical Campus. Before arriving at the university, Dr. Maglione was an attending physician and researcher at the Icahn School of Medicine at Mount Sinai. He completed his MD/PhD training at the Albert Einstein College of Medicine and internal medicine residency at Mount Sinai Hospital in New York. Also at Mount Sinai, Dr. Maglione undertook fellowship training in clinical immunology and post-doctoral research under the mentorship of Charlotte Cunningham-Rundles, MD, PhD, a renowned expert in common variable immunodeficiency.

Clinical Focus:
Dr. Maglione is an attending physician at Boston Medical Center where he focuses on the diagnosis and treatment of primary immunodeficiency disorders, with special expertise in the care of common variable immunodeficiency and its complications. He also attends on the inpatient allergy/immunology service. Dr. Maglione is involved in the teaching of allergy/immunology clinical fellows in the Chobanian and Avedisian School of Medicine program. He has been invited to speak to patient audiences on numerous occasions by the Immune Deficiency Foundation, including their national conference, and cares for patients with immune deficiency disorders from around the country.

Research Focus:
Dr. Maglione studies human B cell biology through the lens of primary immunodeficiency. Dr. Maglione's clinical focus on antibody deficiency syndromes dovetails with his research focus on mechanisms of B cell dysfunction in humans. For numerous years, he has been investigating mechanisms underlying non-infectious complications of the most prevalent form of symptomatic primary antibody deficiency, common variable immunodeficiency (CVID). Recent work has focused upon the pathogenesis of interstitial lung disease affecting CVID patients, particularly upon the biology of B cell dysfunction in this disease. Dr. Maglione has helped devise therapeutic strategies to treat gastrointestinal and pulmonary complications of common variable immunodeficiency. His research utilizes high throughput strategies that include seromics, antibody arrays, genomics, and RNA sequencing coupled with cell culture, biopsies, and information from the medical record to define how B cell defects shape human disease.

Publications

  • Published 5/30/2026

    Matson EM, Ware MS, Feng F, Yu L, Beane JE, Belkina AC, Maglione PJ. Coexistent alterations of BAFF and B cell phenotypes in complicated CVID course. J Allergy Clin Immunol. 2026 May 30. PMID: 42219089.

    Read at: PubMed

  • Published 4/1/2026

    Orange JS, Chinen J, Horner CC, Kobrynski LJ, Ballow M, Butte MJ, Chandrakasan S, Chinn IK, Satter LF, Freeman AF, Heimall JR, Knight V, Lawrence MG, Lehman HK, Maglione PJ, Perez EE, Risma KA, Walter JE, Abraham RS, Barmettler S, Broderick L, Chang CC, Chan AY, Chen K, Connelly J, Danziger-Isakov LA, De la Morena MT, DiGiacomo D, Dimitriades VR, Dorsey MJ, Dulek DE, Dutmer CM, Dvorak CC, Farmer JR, Frazer-Abel A, Joshi AY, Keller MD, Khan YW, Kitcharoensakkul M, Leiding JW, Myers KC, Nandakumar V, Platt CD, Pai SY, Patel NC, Pozos TC, Puck JM, Rider NL, Sacco KA, Williams KW, Lieberman JA, Rank MA, Shaker MS, Abrams EM, Bernstein JA, Chu DK, Ellis AK, Golden DBK, Greenhawt M, Ledford DK, Mosnaim G, Wang J. 2025 Inborn errors of immunity practice parameter: Guidance from the Joint Task Force on Practice Parameters, the American Academy of Allergy, Asthma & Immunology (AAAAI), the American College of Allergy, Asthma and Immunology (ACAAI) and the Clinical Immunology Society (CIS). Ann Allergy Asthma Immunol. 2026 Apr; 136(4):426-493.e1. PMID: 41936423.

    Read at: PubMed

  • Published 3/23/2026

    Hayes KM, Boldt K, Schnorr PJ, Bawa P, Abyazi ML, Ware MS, Gyimesi G, James M, Ko HM, Cunningham-Rundles C, Mizgerd JP, Mostoslavsky G, Kotton DN, Maglione PJ. Heterozygous NFKB1 variant causes inflammatory dysregulation shaped by broader genetic context in common variable immunodeficiency. JCI Insight. 2026 Mar 23; 11(6). PMID: 41869721.

    Read at: PubMed

  • Published 2/19/2025

    Faugno E, Galbraith AA, Walsh K, Maglione PJ, Farmer JR, Ong MS. Experiences with diagnostic delay among underserved racial and ethnic patients: a systematic review of the qualitative literature. BMJ Qual Saf. 2025 Feb 19; 34(3):190-200. PMID: 39496473.

    Read at: PubMed

  • Published 2/12/2025

    Gutzeit C, Grasset EK, Matthews DB, Maglione PJ, Britton GJ, Miller H, Magri G, Tomalin L, Stapylton M, Canales-Herrerias P, Sominskaia M, Guzman M, Pybus M, Tejedor Vaquero S, Radigan L, Tachó-Piñot R, Martín Nalda A, García Prat M, Martinez Gallo M, Dieli-Crimi R, Clemente JC, Mehandru S, Suarez-Farinas M, Faith JJ, Cunningham-Rundles C, Cerutti A. Gut IgA functionally interacts with systemic IgG to enhance antipneumococcal vaccine responses. Sci Adv. 2025 Feb 14; 11(7):eado9455. PMID: 39937896.

    Read at: PubMed

View All 51 Publications:   View Full Profile in BUMC

Other Positions

  • Member, Pulmonary Center
    Boston University
  • Graduate Medical Sciences Educator and Mentor (Primary Mentor of Graduate Students)
    Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences

Websites

Education

  • University of Rochester, BS
  • Albert Einstein College of Medicine, MD/PhD

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