Nancy Kopell, PhD
Professor, Mathematics and Statistics
Biography
Nancy Kopell received her B.A. from Cornell University in 1963 and her Ph.D. from Berkeley in 1967. She is currently the William Fairfield Warren Distinguished Professor at Boston University, and co-director of the Center for Computational Neuroscience and Neural Technology (CompNet). She organized and directs the Cognitive Rhythms Collaborative (CRC), a group of over two dozen labs, mostly in the Boston Area, working on brain dyanmics and their cognitive implications.
Kopell’s Ph.D. training was in pure mathematics, but she transitioned to applied mathematics shortly after receiving her degree. In the first part of her career, she worked on pattern formation in chemical systems, oscillating systems and problems involving the geometry of systems with multiple time scales. For the last two decades, she has worked on mathematical problems in neuroscience. Her current interests parallel the themes of the CRC: how does the brain produce its dynamics (physiological mechanisms), how do brain rhythms take part in cognition (sensory processing, attention, memory, motor control), and how can pathologies of brain dynamics help to understand symptoms of neurological diseases (Parkinson’s disease, schizophrenia, epilepsy) as well as alternate states of consciousness (anesthesia). She collaborates widely with experimentalists and clinicians.
Kopell is a member of the National Academy of Sciences and the American Academy of Arts and Sciences. She was recently selected to be an honorary member of the London Mathematical Society, a distinction given to one or two mathematicians per year worldwide. She has been awarded Sloan Guggenheim, and McArthur Fellowships, and has an honory Ph.D. from the New Jersey Institute of Technology. She has given the Weldon Memorial Prize Lecture (Oxford), the von Neumann Lecture (SIAM) and the Josiah Willard Gibbs Lecture (AMS, as well as multiple other named lectureships.
Other Positions
- Professor, Pharmacology, Physiology & Biophysics, Boston University Chobanian & Avedisian School of Medicine
- Co-Director, Engineering, Boston University
Education
- University of California, Berkeley, PhD
- University of California, Berkeley, MA
- Cornell University, AB
Publications
- Published on 11/26/2024
Cattani A, Arnold DB, McCarthy M, Kopell N. Basolateral amygdala oscillations enable fear learning in a biophysical model. Elife. 2024 Nov 26; 12. PMID: 39590510.
Read at: PubMed - Published on 5/20/2024
Adam E, Kowalski M, Akeju O, Miller EK, Brown EN, McCarthy MM, Kopell N. Ketamine can produce oscillatory dynamics by engaging mechanisms dependent on the kinetics of NMDA receptors. Proc Natl Acad Sci U S A. 2024 May 28; 121(22):e2402732121. PMID: 38768339.
Read at: PubMed - Published on 4/5/2024
Adam E, Kowalski M, Akeju O, Miller EK, Brown EN, McCarthy MM, Kopell N. Ketamine can produce oscillatory dynamics by engaging mechanisms dependent on the kinetics of NMDA receptors. bioRxiv. 2024 Apr 05. PMID: 38617266.
Read at: PubMed - Published on 2/28/2024
Murdock MH, Yang CY, Sun N, Pao PC, Blanco-Duque C, Kahn MC, Kim T, Lavoie NS, Victor MB, Islam MR, Galiana F, Leary N, Wang S, Bubnys A, Ma E, Akay LA, Sneve M, Qian Y, Lai C, McCarthy MM, Kopell N, Kellis M, Piatkevich KD, Boyden ES, Tsai LH. Multisensory gamma stimulation promotes glymphatic clearance of amyloid. Nature. 2024 Mar; 627(8002):149-156. PMID: 38418876.
Read at: PubMed - Published on 6/14/2023
Soplata AE, Adam E, Brown EN, Purdon PL, McCarthy MM, Kopell N. Rapid thalamocortical network switching mediated by cortical synchronization underlies propofol-induced EEG signatures: a biophysical model. J Neurophysiol. 2023 Jul 01; 130(1):86-103. PMID: 37314079.
Read at: PubMed - Published on 4/28/2023
Cattani A, Arnold DB, McCarthy M, Kopell N. Basolateral amygdala oscillations enable fear learning in a biophysical model. bioRxiv. 2023 Apr 28. PMID: 37163011.
Read at: PubMed - Published on 1/31/2023
Aussel A, Fiebelkorn IC, Kastner S, Kopell NJ, Pittman-Polletta BR. Interacting rhythms enhance sensitivity of target detection in a fronto-parietal computational model of visual attention. Elife. 2023 Jan 31; 12. PMID: 36718998.
Read at: PubMed - Published on 1/4/2023
Quast KB, Reh RK, Caiati MD, Kopell N, McCarthy MM, Hensch TK. Rapid synaptic and gamma rhythm signature of mouse critical period plasticity. Proc Natl Acad Sci U S A. 2023 Jan 10; 120(2):e2123182120. PMID: 36598942.
Read at: PubMed - Published on 5/6/2022
Hass J, Ardid S, Sherfey J, Kopell N. Constraints on persistent activity in a biologically detailed network model of the prefrontal cortex with heterogeneities. Prog Neurobiol. 2022 Aug; 215:102287. PMID: 35533813.
Read at: PubMed - Published on 5/2/2022
Adam EM, Brown EN, Kopell N, McCarthy MM. Deep brain stimulation in the subthalamic nucleus for Parkinson's disease can restore dynamics of striatal networks. Proc Natl Acad Sci U S A. 2022 May 10; 119(19):e2120808119. PMID: 35500112.
Read at: PubMed
View 202 more publications: View full profile at BUMC