Michael J. Rynkiewicz, PhD

Instructor, Boston University Chobanian & Avedisian School of Medicine

Biography

I am a protein crystallographer with extensive experience in computational structural analysis. My work over the years has encompassed a broad range of techniques, including protein crystallography, kinetic assays, organic synthesis, NMR and ultraviolet spectroscopy, small molecule structure-based drug design, epitope mapping of antibodies, and molecular dynamics calculations.

Publications

  • Published 12/22/2025

    Chitre K, Karpicheva OE, King CJ, Rynkiewicz MJ, Fenwick AJ, Dawson JF, Foster DB, Lehman W, Cammarato A. Pseudo-acetylation of ACTC1 K326 and K328 promotes dysinhibition of reconstituted human cardiac thin filaments. J Mol Cell Cardiol. 2026 Mar; 212:10-15. PMID: 41443503.

    Read at: PubMed

  • Published 6/17/2025

    Halder SS, Bellitto JG, Rynkiewicz MJ, Cheung F, Liu D, Firlar I, Bongiorno A, Barry ME, Sewanan LR, Moore JR, Lehman W, Campbell SG. Evaluating Pathogenicity of TPM1 Variants of Unknown Significance Using In-silico and In-vitro Models. J Precis Med (Amst). 2025 Jul; 2. PMID: 42238220.

    Read at: PubMed

  • Published 4/21/2025

    Wen J, Campbell S, Moore J, Lehman W, Rynkiewicz M. Screening single nucleotide changes to tropomyosin to identify novel cardiomyopathy mutants. J Mol Cell Cardiol. 2025 Jun; 203:82-90. PMID: 40268117.

    Read at: PubMed

  • Published 3/8/2025

    Ramachandran B, Rynkiewicz M, Lehman W. Velcro-binding by cardiac troponin-I traps tropomyosin on actin in a low-energy relaxed state. Biochem Biophys Res Commun. 2025 Apr 09; 757:151595. PMID: 40088678.

    Read at: PubMed

  • Published 3/6/2025

    Barry ME, Rynkiewicz MJ, Wen J, Tu AY, Regnier M, Lehman W, Moore JR. Dual role of Tropomyosin-R160 in thin filament regulation: Insights into phosphorylation-dependent cardiac relaxation and cardiomyopathy mechanisms. Arch Biochem Biophys. 2025 Jun; 768:110380. PMID: 40057222.

    Read at: PubMed

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Websites

Education

  • Boston University School of Medicine, PhD
  • Massachusetts Institute of Technology, BS

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