Michael J. Rynkiewicz, PhD

Instructor, Boston University Chobanian & Avedisian School of Medicine

Biography

I am a protein crystallographer with extensive experience in computational structural analysis. My work over the years has encompassed a broad range of techniques, including protein crystallography, kinetic assays, organic synthesis, NMR and ultraviolet spectroscopy, small molecule structure-based drug design, epitope mapping of antibodies, and molecular dynamics calculations.

Publications

  • Published 4/21/2025

    Wen J, Campbell S, Moore J, Lehman W, Rynkiewicz M. Screening single nucleotide changes to tropomyosin to identify novel cardiomyopathy mutants. J Mol Cell Cardiol. 2025 Jun; 203:82-90. PMID: 40268117.

    Read at: PubMed

  • Published 3/8/2025

    Ramachandran B, Rynkiewicz M, Lehman W. Velcro-binding by cardiac troponin-I traps tropomyosin on actin in a low-energy relaxed state. Biochem Biophys Res Commun. 2025 Apr 09; 757:151595. PMID: 40088678.

    Read at: PubMed

  • Published 3/6/2025

    Barry ME, Rynkiewicz MJ, Wen J, Tu AY, Regnier M, Lehman W, Moore JR. Dual role of Tropomyosin-R160 in thin filament regulation: Insights into phosphorylation-dependent cardiac relaxation and cardiomyopathy mechanisms. Arch Biochem Biophys. 2025 Jun; 768:110380. PMID: 40057222.

    Read at: PubMed

  • Published 1/16/2025

    Doran MH, Rynkiewicz MJ, Despond E, Viswanathan MC, Madan A, Chitre K, Fenwick AJ, Sousa D, Lehman W, Dawson JF, Cammarato A. The hypertrophic cardiomyopathy-associated A331P actin variant enhances basal contractile activity and elicits resting muscle dysfunction. iScience. 2025 Feb 21; 28(2):111816. PMID: 39981516.

    Read at: PubMed

  • Published 12/16/2024

    Halder SS, Rynkiewicz MJ, Kim L, Barry ME, Zied AG, Sewanan LR, Kirk JA, Moore JR, Lehman WJ, Campbell SG. Distinct mechanisms drive divergent phenotypes in hypertrophic and dilated cardiomyopathy-associated TPM1 variants. J Clin Invest. 2024 Dec 16; 134(24). PMID: 39436707.

    Read at: PubMed

Education

  • Boston University School of Medicine, PhD
  • Massachusetts Institute of Technology, BS