Michael J. Rynkiewicz, PhD
Instructor, Pharmacology, Physiology & Biophysics
Biography
I am a protein crystallographer with extensive experience in computational structural analysis. My work over the years has encompassed a broad range of techniques, including protein crystallography, kinetic assays, organic synthesis, NMR and ultraviolet spectroscopy, small molecule structure-based drug design, epitope mapping of antibodies, and molecular dynamics calculations.
Education
- Boston University School of Medicine, PhD
- Massachusetts Institute of Technology, BS
Publications
- Published on 1/16/2025
Doran MH, Rynkiewicz MJ, Despond E, Viswanathan MC, Madan A, Chitre K, Fenwick AJ, Sousa D, Lehman W, Dawson JF, Cammarato A. The hypertrophic cardiomyopathy-associated A331P actin variant enhances basal contractile activity and elicits resting muscle dysfunction. iScience. 2025 Feb 21; 28(2):111816. PMID: 39981516.
Read at: PubMed - Published on 12/16/2024
Halder SS, Rynkiewicz MJ, Kim L, Barry ME, Zied AG, Sewanan LR, Kirk JA, Moore JR, Lehman WJ, Campbell SG. Distinct mechanisms drive divergent phenotypes in hypertrophic and dilated cardiomyopathy-associated TPM1 variants. J Clin Invest. 2024 Dec 16; 134(24). PMID: 39436707.
Read at: PubMed - Published on 8/30/2024
Creso JG, Gokhan I, Rynkiewicz MJ, Lehman W, Moore JR, Campbell SG. In silico and in vitro models reveal the molecular mechanisms of hypocontractility caused by TPM1 M8R. Front Physiol. 2024; 15:1452509. PMID: 39282088.
Read at: PubMed - Published on 4/12/2024
Rynkiewicz MJ, Childers MC, Karpicheva OE, Regnier M, Geeves MA, Lehman W. Myosin's powerstroke transitions define atomic scale movement of cardiac thin filament tropomyosin. J Gen Physiol. 2024 May 06; 156(5). PMID: 38607351.
Read at: PubMed - Published on 1/22/2024
Barry ME, Rynkiewicz MJ, Pavadai E, Viana A, Lehman W, Moore JR. Glutamate 139 of tropomyosin is critical for cardiac thin filament blocked-state stabilization. J Mol Cell Cardiol. 2024 Mar; 188:30-37. PMID: 38266978.
Read at: PubMed - Published on 11/27/2023
Lewkowicz E, Nakamura MN, Rynkiewicz MJ, Gursky O. Molecular modeling of apoE in complexes with Alzheimer's amyloid-ß fibrils from human brain suggests a structural basis for apolipoprotein co-deposition with amyloids. Cell Mol Life Sci. 2023 Nov 27; 80(12):376. PMID: 38010414.
Read at: PubMed - Published on 8/6/2023
Lewkowicz E, Nakamura MN, Rynkiewicz MJ, Gursky O. Molecular modeling of apoE in complexes with Alzheimer's amyloid-ß fibrils from human brain suggests a structural basis for apolipoprotein co-deposition with amyloids. bioRxiv. 2023 Aug 06. PMID: 37577501.
Read at: PubMed - Published on 5/30/2023
Lehman W, Rynkiewicz MJ. Troponin-I-induced tropomyosin pivoting defines thin-filament function in relaxed and active muscle. J Gen Physiol. 2023 Jul 03; 155(7). PMID: 37249525.
Read at: PubMed - Published on 1/21/2023
Halder SS, Rynkiewicz MJ, Creso JG, Sewanan LR, Howland L, Moore JR, Lehman W, Campbell SG. Mechanisms of pathogenicity in the hypertrophic cardiomyopathy-associated TPM1 variant S215L. PNAS Nexus. 2023 Mar; 2(3):pgad011. PMID: 36896133.
Read at: PubMed - Published on 1/12/2023
Doran MH, Rynkiewicz MJ, Rassici D, Bodt SML, Barry ME, Bullitt E, Yengo CM, Moore JR, Lehman W. Conformational changes linked to ADP release from human cardiac myosin bound to actin-tropomyosin. J Gen Physiol. 2023 Mar 06; 155(3). PMID: 36633586.
Read at: PubMed
View 51 more publications: View full profile at BUMC