-
Published 4/21/2025
Wen J, Campbell S, Moore J, Lehman W, Rynkiewicz M. Screening single nucleotide changes to tropomyosin to identify novel cardiomyopathy mutants. J Mol Cell Cardiol. 2025 Jun; 203:82-90. PMID: 40268117.
-
Published 3/8/2025
Ramachandran B, Rynkiewicz M, Lehman W. Velcro-binding by cardiac troponin-I traps tropomyosin on actin in a low-energy relaxed state. Biochem Biophys Res Commun. 2025 Apr 09; 757:151595. PMID: 40088678.
-
Published 3/6/2025
Barry ME, Rynkiewicz MJ, Wen J, Tu AY, Regnier M, Lehman W, Moore JR. Dual role of Tropomyosin-R160 in thin filament regulation: Insights into phosphorylation-dependent cardiac relaxation and cardiomyopathy mechanisms. Arch Biochem Biophys. 2025 Jun; 768:110380. PMID: 40057222.
-
Published 1/16/2025
Doran MH, Rynkiewicz MJ, Despond E, Viswanathan MC, Madan A, Chitre K, Fenwick AJ, Sousa D, Lehman W, Dawson JF, Cammarato A. The hypertrophic cardiomyopathy-associated A331P actin variant enhances basal contractile activity and elicits resting muscle dysfunction. iScience. 2025 Feb 21; 28(2):111816. PMID: 39981516.
-
Published 12/16/2024
Halder SS, Rynkiewicz MJ, Kim L, Barry ME, Zied AG, Sewanan LR, Kirk JA, Moore JR, Lehman WJ, Campbell SG. Distinct mechanisms drive divergent phenotypes in hypertrophic and dilated cardiomyopathy-associated TPM1 variants. J Clin Invest. 2024 Dec 16; 134(24). PMID: 39436707.