Matthew G. Nayor, MD, MPH
Associate Professor, Medicine
Biography
Dr. Nayor is a clinical-translational investigator and heart failure cardiologist. He received training in Internal Medicine at the Johns Hopkins Hospital Osler Medical Residency training program and Cardiology and Heart Failure and Transplantation training at Brigham and Women’s Hospital. His research background includes basic science investigations, physiologic studies, and cardiovascular epidemiology focusing on the intersection of metabolic health and cardiovascular disease. His group and collaborators have studied: 1) the effect of exercise on metabolism via assaying >500 circulating metabolites; 2) physiologic determinants of fitness; 3) novel protein biomarkers of heart failure risk through broad proteomic profiling; 4) and lifestyle contributors to cardiometabolic disease and heart failure, among other topics.
Dr. Nayor has worked closely with the Framingham Heart Study for the last 8 years and currently leads community-based studies evaluating metabolic responses to discrete physiologic perturbations, such as exercise and a dietary intervention.
Other Positions
- Assistant Professor, Preventive Medicine & Epidemiology, Medicine, Boston University Chobanian & Avedisian School of Medicine
Education
- New York University School of Medicine, MD
- Harvard School of Public Health, MPH
- University of Michigan at Ann Arbor, BA
Publications
- Published on 2/14/2025
Iyer KR, Clarke SL, Guarischi-Sousa R, Gjoni K, Heath AS, Young EP, Stitziel NO, Laurie C, Broome JG, Khan AT, Lewis JP, Xu H, Montasser ME, Ashley KE, Hasbani NR, Boerwinkle E, Morrison AC, Chami N, Do R, Rocheleau G, Lloyd-Jones DM, Lemaitre RN, Bis JC, Floyd JS, Kinney GL, Bowden DW, Palmer ND, Benjamin EJ, Nayor M, Yanek LR, Kral BG, Becker LC, Kardia SLR, Smith JA, Bielak LF, Norwood AF, Min YI, Carson AP, Post WS, Rich SS, Herrington D, Guo X, Taylor KD, Manson JE, Franceschini N, Pollard KS, Mitchell BD, Loos RJF, Fornage M, Hou L, Psaty BM, Young KA, Regan EA, Freedman BI, Vasan RS, Levy D, Mathias RA, Peyser PA, Raffield LM, Kooperberg C, Reiner AP, Rotter JI, Jun G, de Vries PS, Assimes TL. Unveiling the Genetic Landscape of Coronary Artery Disease Through Common and Rare Structural Variants. J Am Heart Assoc. 2025 Feb 18; 14(4):e036499. PMID: 39950338.
Read at: PubMed - Published on 1/7/2025
Rade JJ, Kronsberg SS, Kickler TS, Vasan RS, Xanthakis V, Nayor MG, Barton BA. Association of Systemic Thromboxane Generation With Risk of Developing Heart Failure. J Am Coll Cardiol. 2025 Jan 07; 85(1):58-70. PMID: 39779056.
Read at: PubMed - Published on 1/1/2025
Florea VV, Gajjar P, Huang S, Tang J, Zhao S, Davenport M, Mi MY, Haff M, Zhang X, Miller PE, Vasan RS, Liu CT, Lewis GD, Shah RV, Long MT, Nayor M. Hepatic Steatosis and Fibrosis, Cardiorespiratory Fitness, and Metabolic Mediators in the Community. Liver Int. 2025 Jan; 45(1):e16147. PMID: 39673712.
Read at: PubMed - Published on 12/9/2024
Perry AS, Hadad N, Chatterjee E, Jimenez-Ramos M, Farber-Eger E, Roshani R, Stolze LK, Betti MJ, Zhao S, Huang S, Martens L, Kendall TJ, Thone T, Amancherla K, Bailin S, Gabriel CL, Koethe J, Carr JJ, Terry JG, Vaitinadin NS, Freedman JE, Tanriverdi K, Alsop E, Van Keuren-Jensen K, Sauld JFK, Mahajan G, Khan SS, Colangelo L, Nayor M, Fisher-Hoch S, McCormick JB, North KE, Below JE, Wells QS, Abel ED, Kalhan R, Scott C, Guilliams M, Gamazon ER, Fallowfield JA, Banovich NE, Das S, Shah R. A prognostic molecular signature of hepatic steatosis is spatially heterogeneous and dynamic in human liver. Cell Rep Med. 2024 Dec 17; 5(12):101871. PMID: 39657669.
Read at: PubMed - Published on 11/22/2024
Perry AS, Piaggi P, Huang S, Nayor M, Freedman J, North KE, Below JE, Clish CB, Murthy VL, Krakoff J, Shah RV. Human metabolic chambers reveal a coordinated metabolic-physiologic response to nutrition. JCI Insight. 2024 Nov 22; 9(22). PMID: 39576013.
Read at: PubMed - Published on 11/15/2024
Wang MC, Awoyemi T, Allen NB, Shah R, Nayor M, Luo Y, Lima JAC, Lloyd-Jones DM, Khan SS. Latent class analysis of cardiac structure and function and association with premature cardiovascular disease: The Coronary Artery Risk Development in Young Adults (CARDIA) study. Am J Prev Cardiol. 2024 Dec; 20:100889. PMID: 39655179.
Read at: PubMed - Published on 10/16/2024
McCormick N, Joshi AD, Yokose C, Yu B, Tin A, Terkeltaub R, Merriman TR, Zeleznik O, Eliassen AH, Curhan GC, Ea HK, Nayor M, Raffield LM, Choi HK. Prediagnostic Amino Acid Metabolites and Risk of Gout, Accounting for Serum Urate: Prospective Cohort Study and Mendelian Randomization. Arthritis Care Res (Hoboken). 2024 Dec; 76(12):1666-1674. PMID: 39169570.
Read at: PubMed - Published on 10/14/2024
Lim K, Nayor M, Arroyo E, Burney HN, Li X, Li Y, Shah R, Campain J, Wan D, Ting S, Hiemstra TF, Thadhani R, Moe S, Zehnder D, Larson MG, Vasan RS, Lewis GD. Impairment of Cardiovascular Functional Capacity in Mild-to-Moderate Kidney Dysfunction. Clin J Am Soc Nephrol. 2024 Dec 01; 19(12):1547-1561. PMID: 39401313.
Read at: PubMed - Published on 9/2/2024
Perry AS, Amancherla K, Huang X, Lance ML, Farber-Eger E, Gajjar P, Amrute J, Stolze L, Zhao S, Sheng Q, Joynes CM, Peng Z, Tanaka T, Drakos SG, Lavine KJ, Selzman C, Visker JR, Shankar TS, Ferrucci L, Das S, Wilcox J, Patel RB, Kalhan R, Shah SJ, Walker KA, Wells Q, Tucker N, Nayor M, Shah RV, Khan SS. Clinical-transcriptional prioritization of the circulating proteome in human heart failure. Cell Rep Med. 2024 Sep 17; 5(9):101704. PMID: 39226894.
Read at: PubMed - Published on 8/8/2024
Eromosele OB, Shapira-Daniels A, Yuan A, Lukan A, Akinrimisi O, Chukwurah M, Nayor M, Benjamin EJ, Lin H. The association of exhaled carbon monoxide with atrial fibrillation and left atrial size in the Framingham Heart Study. Am Heart J Plus. 2024 Sep; 45:100439. PMID: 39234302.
Read at: PubMed
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