Matthew G. Nayor, MD, MPH

Associate Professor, Boston University Chobanian & Avedisian School of Medicine

Biography

Dr. Nayor is a clinical-translational investigator and heart failure cardiologist. He received training in Internal Medicine at the Johns Hopkins Hospital Osler Medical Residency training program and Cardiology and Heart Failure and Transplantation training at Brigham and Women's Hospital. His research background includes basic science investigations, physiologic studies, and cardiovascular epidemiology focusing on the intersection of metabolic health and cardiovascular disease. His group and collaborators have studied: 1) the effect of exercise on metabolism via assaying >500 circulating metabolites; 2) physiologic determinants of fitness; 3) novel protein biomarkers of heart failure risk through broad proteomic profiling; 4) and lifestyle contributors to cardiometabolic disease and heart failure, among other topics.

Dr. Nayor has worked closely with the Framingham Heart Study for the last 8 years and currently leads community-based studies evaluating metabolic responses to discrete physiologic perturbations, such as exercise and a dietary intervention.

Publications

  • Published 2/17/2026

    Perry AS, O'Connor C, Pavicic M, Sheng Q, Farber-Eger E, Sarkar A, Lin P, Evans P, Tanriverdi K, Risitano A, Peters AE, Chen H, Upadhya B, Whellan DJ, Pastva A, Mentz RJ, Bertoni A, Semelka C, Brubaker PH, Molina AJA, Newland R, Nelson B, Lane M, Sullivan KA, Townsend A, Vlot A, Nsoh B, Allen PD, Wells Q, Reeves GR, Jacobson D, Kitzman DW, Gamazon ER, Nayor M, Shah RV. A multi-layered approach to elucidate mechanisms of physical function in response to rehabilitation in heart failure with preserved ejection fraction. medRxiv. 2026 Feb 17. PMID: 41757200.

    Read at: PubMed

  • Published 2/12/2026

    Davis DN, Gajjar P, Xanthakis V, Lloyd-Jones D, Nayor M. Refined Heart Failure Stages Incorporating Cardiorespiratory Fitness Are Differentially Associated With Heart Failure Risk in the Community. J Am Heart Assoc. 2026 Feb 17; 15(4):e045791. PMID: 41676947.

    Read at: PubMed

  • Published 10/31/2025

    Landman JM, Highland HM, Perry AS, Howard AG, Sheng Q, Lorenz A, Palmer AB, Zhao S, Zhu W, Zhang X, Buchanan VL, Frankel EG, Roshani R, Scartozzi A, Farber-Eger EH, Anwar MY, Sprinkles JK, Breidenbach A, Wang TC, Ballard CA, Nayor M, Tamaroff J, Gutierrez A, Petty LE, Petty AS, Lippi B, Fernandez-Rhodes L, Chen HH, Krishnan M, Graff M, Meyer KA, Lee M, Young KL, Wells Q, Freedman JE, Gamazon ER, McCormick JB, Fisher-Hoch SP, Gordon-Larsen P, Below JE, North KE, Shah RV. Proteomic signatures of pediatric cardiovascular and cardiometabolic traits demonstrate long-term modifiable drivers of adult disease. medRxiv. 2025 Oct 31. PMID: 41282792.

    Read at: PubMed

  • Published 8/23/2025

    Jha M, Dong Z, Ruda MM, Prescott B, Xanthakis V, Nayor M, Gajjar P, Larson MG, Benjamin EJ, Vasan RS, Mitchell GF, Tsao CW. Associations of cardiovascular health with arterial health in adults free of cardiovascular disease. Am J Prev Cardiol. 2025 Sep; 23:101083. PMID: 40918934.

    Read at: PubMed

  • Published 7/26/2025

    Lindman BR, Perry AS, Lance ML, Amancherla K, Kim N, Sheng Q, Lin P, Pfeiffer RD, Farber-Eger E, Fearon WF, Kapadia S, Kumbhani DJ, Gillam L, Mallugari RR, Gupta DK, Miller FJ, Vatterott A, Jackson N, Su YR, Tomasek K, Absi T, Freedman JE, Nayor M, Das S, Wells QS, Dweck MR, Gerszten RE, Gamazon ER, Tucker NR, Shah R, Elmariah S. Integrated multiomics of pressure overload in the human heart prioritizes targets relevant to heart failure. Nat Commun. 2025 Jul 26; 16(1):6889. PMID: 40715126.

    Read at: PubMed

View All 102 Publications:   View Full Profile in BUMC

Other Positions

  • Assistant Professor, Medicine
    Boston University Chobanian & Avedisian School of Medicine

Websites

Education

  • New York University School of Medicine, MD
  • Harvard School of Public Health, MPH
  • University of Michigan at Ann Arbor, BA

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