Mary Fisher, MD, PhD

Associate Professor, Pharmacology, Physiology & Biophysics

Mary Fisher


Dr. Fisher’s work has been instrumental in establishing the zebrafish as a model organism for the study of skeletal dysplasias, including her identical for a zebrafish model for Osteogenesis Imperfection and publication of the first osteoblast markers. She pioneered the use of zebrafish to analyze transcriptional and regulatory elements from the human genome, and has identified and studied dozens of enhancers associated with skeletal genes. Her most recent efforts are focused on skull development, an area of tremendous clinical relevance not well studied in zebrafish.

Other Positions

  • Member, Genome Science Institute, Boston University
  • Graduate Faculty (Primary Mentor of Grad Students), Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences


  • Johns Hopkins University School of Medicine, MD
  • Johns Hopkins University School of Medicine, PhD
  • Purdue University, BS

Classes Taught

  • GMSFC715


  • Published on 6/10/2016

    Brinkley JF, Fisher S, Harris MP, Holmes G, Hooper JE, Jabs EW, Jones KL, Kesselman C, Klein OD, Maas RL, Marazita ML, Selleri L, Spritz RA, van Bakel H, Visel A, Williams TJ, Wysocka J, Chai Y. The FaceBase Consortium: a comprehensive resource for craniofacial researchers. Development. 2016 Jul 15; 143(14):2677-88. PMID: 27287806.

    Read at: PubMed
  • Published on 3/16/2016

    Kague E, Roy P, Asselin G, Hu G, Simonet J, Stanley A, Albertson C, Fisher S. Osterix/Sp7 limits cranial bone initiation sites and is required for formation of sutures. Dev Biol. 2016 May 15; 413(2):160-72. PMID: 26992365.

    Read at: PubMed
  • Published on 9/11/2014

    Esteves FF, Springhorn A, Kague E, Taylor E, Pyrowolakis G, Fisher S, Bier E. BMPs regulate msx gene expression in the dorsal neuroectoderm of Drosophila and vertebrates by distinct mechanisms. PLoS Genet. 2014 Sep; 10(9):e1004625. PMID: 25210771.

    Read at: PubMed
  • Published on 7/1/2013

    Costa AM, Pereira-Castro I, Ricardo E, Spencer F, Fisher S, da Costa LT. GRG5/AES interacts with T-cell factor 4 (TCF4) and downregulates Wnt signaling in human cells and zebrafish embryos. PLoS One. 2013; 8(7):e67694. PMID: 23840876.

    Read at: PubMed
  • Published on 11/14/2012

    Kague E, Gallagher M, Burke S, Parsons M, Franz-Odendaal T, Fisher S. Skeletogenic fate of zebrafish cranial and trunk neural crest. PLoS One. 2012; 7(11):e47394. PMID: 23155370.

    Read at: PubMed
  • Published on 7/20/2012

    Hu G, Codina M, Fisher S. Multiple enhancers associated with ACAN suggest highly redundant transcriptional regulation in cartilage. Matrix Biol. 2012 Jul; 31(6):328-37. PMID: 22820679.

    Read at: PubMed
  • Published on 10/19/2011

    Maragh S, Miller RA, Bessling SL, McGaughey DM, Wessels MW, de Graaf B, Stone EA, Bertoli-Avella AM, Gearhart JD, Fisher S, McCallion AS. Identification of RNA binding motif proteins essential for cardiovascular development. BMC Dev Biol. 2011 Oct 19; 11:62. PMID: 22011202.

    Read at: PubMed
  • Published on 7/29/2011

    Hu G, Goll MG, Fisher S. FC31 integrase mediates efficient cassette exchange in the zebrafish germline. Dev Dyn. 2011 Sep; 240(9):2101-7. PMID: 21805532.

    Read at: PubMed
  • Published on 5/17/2011

    Knopf F, Hammond C, Chekuru A, Kurth T, Hans S, Weber CW, Mahatma G, Fisher S, Brand M, Schulte-Merker S, Weidinger G. Bone regenerates via dedifferentiation of osteoblasts in the zebrafish fin. Dev Cell. 2011 May 17; 20(5):713-24. PMID: 21571227.

    Read at: PubMed
  • Published on 7/16/2010

    Kague E, Weber C, Fisher S. Mosaic zebrafish transgenesis for evaluating enhancer sequences. J Vis Exp. 2010 Jul 16; (41). PMID: 20679998.

    Read at: PubMed

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