Louis C. Gerstenfeld, PhD
Professor, Orthopaedic Surgery
Biography
My expertise is in the area of skeletal tissue biology. I have studied skeletal biology for more than 30 years and have broad knowledge across many areas in the field, including metabolic bone disease and orthopedic-related diseases. I have carried out numerous pre-clinical assessments of pharmacological compounds as they relate to safety and efficacy in the treatment of fracture and osteoporosis. I have expertise in skeletal tissue structure and the histomorphometric assessment of skeletal tissues, skeletal tissue cell biology and skeletal tissue transcriptomics. I was among the first four labs in the United States to develop in vitro osteoblast cultures and helped to establish the standard time dependent sequence of osteogenic differentiation in vitro. My laboratory also was one of four to initially isolate the proteins and clone the major extracellular matrix proteins of bone. I have served on the NIH IRG for Orthopedics, NASA and DOD review panels for orthopedic related research and worked on Special Emphasis Review Panels for the FDA. My current work focuses on relating genomic variants that define human bone quality to transcriptomic phenotypes of ostoeblasts and osteoclasts. Other studies in laboratory are focused on developing serum based diagnostics to follow the progression of fracture healing and define delayed and failed healing in humans.
Other Positions
- Research Professor, Biochemistry & Cell Biology, Boston University Chobanian & Avedisian School of Medicine
- Professor, Pulmonary, Allergy, Sleep & Critical Care Medicine, Medicine, Boston University Chobanian & Avedisian School of Medicine
- Member, Center for Regenerative Medicine, Boston University
- Member, Evans Center for Interdisciplinary Biomedical Research, Boston University
- Graduate Faculty (Primary Mentor of Grad Students), Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences
Education
- Boston University School of Medicine, PhD
- Pennsylvania State University, BA
- Pennsylvania State University, BS
Publications
- Published on 10/18/2024
Jaber M, Schmidt J, Kalkhof S, Gerstenfeld L, Duda GN, Checa S. OMIBONE: Omics-driven computer model of bone regeneration for personalized treatment. Bone. 2025 Jan; 190:117288. PMID: 39426580.
Read at: PubMed - Published on 6/11/2024
Blank K, Ekanayake D, Cooke M, Bragdon B, Hussein A, Gerstenfeld L. Relationships between matrix mineralization, oxidative metabolism, and mitochondrial structure during ATDC5 murine chondroprogenitor cell line differentiation. J Cell Physiol. 2024 Aug; 239(8):e31285. PMID: 38860464.
Read at: PubMed - Published on 1/30/2023
Liu Y, Ilinski A, Gerstenfeld LC, Bragdon B. Prx1 cell subpopulations identified in various tissues with diverse quiescence and activation ability following fracture and BMP2 stimulation. Front Physiol. 2023; 14:1106474. PMID: 36793419.
Read at: PubMed - Published on 1/23/2023
Hussein AI, Carroll D, Bui M, Wolff A, Matheny H, Hogue B, Lybrand K, Cooke M, Bragdon B, Morgan E, Demissie S, Gerstenfeld L. Oxidative metabolism is impaired by phosphate deficiency during fracture healing and is mechanistically related to BMP induced chondrocyte differentiation. Bone Rep. 2023 Jun; 18:101657. PMID: 37425193.
Read at: PubMed - Published on 11/23/2022
Al-Barghouthi BM, Rosenow WT, Du KP, Heo J, Maynard R, Mesner L, Calabrese G, Nakasone A, Senwar B, Gerstenfeld L, Larner J, Ferguson V, Ackert-Bicknell C, Morgan E, Brautigan D, Farber CR. Transcriptome-wide association study and eQTL colocalization identify potentially causal genes responsible for human bone mineral density GWAS associations. Elife. 2022 Nov 23; 11. PMID: 36416764.
Read at: PubMed - Published on 7/13/2022
Abood A, Mesner L, Rosenow W, Al-Barghouthi BM, Horowitz N, Morgan EF, Gerstenfeld LC, Farber CR. Identification of Known and Novel Long Noncoding RNAs Potentially Responsible for the Effects of Bone Mineral Density (BMD) Genomewide Association Study (GWAS) Loci. J Bone Miner Res. 2022 Aug; 37(8):1500-1510. PMID: 35695880.
Read at: PubMed - Published on 7/8/2022
Karagianni A, Matsuura S, Gerstenfeld LC, Ravid K. Inhibition of Osteoblast Differentiation by JAK2V617F Megakaryocytes Derived From Male Mice With Primary Myelofibrosis. Front Oncol. 2022; 12:929498. PMID: 35880162.
Read at: PubMed - Published on 5/13/2022
Nakasone A, Guang Y, Wise A, Kim L, Babbin J, Rathod S, Mitchell AJ, Gerstenfeld LC, Morgan EF. Structural features of subchondral bone cysts and adjacent tissues in hip osteoarthritis. Osteoarthritis Cartilage. 2022 Aug; 30(8):1130-1139. PMID: 35569801.
Read at: PubMed - Published on 3/26/2022
Bragdon BC, Bennie A, Molinelli A, Liu Y, Gerstenfeld LC. Post natal expression of Prx1 labels appendicular restricted progenitor cell populations of multiple tissues. J Cell Physiol. 2022 May; 237(5):2550-2560. PMID: 35338481.
Read at: PubMed - Published on 12/10/2021
Lu D, Demissie S, Horowitz NB, Gower AC, Lenburg ME, Alekseyev YO, Hussein AI, Bragdon B, Liu Y, Daukss D, Page JM, Webster MZ, Schlezinger JJ, Morgan EF, Gerstenfeld LC. Temporal and Quantitative Transcriptomic Differences Define Sexual Dimorphism in Murine Postnatal Bone Aging. JBMR Plus. 2022 Feb; 6(2):e10579. PMID: 35229061.
Read at: PubMed
View 206 more publications: View full profile at BUMC