Lauren E Brown
Research Associate Professor, Chemistry
Other Positions
- Research Assistant Professor, Pharmacology, Physiology & Biophysics, Boston University Chobanian & Avedisian School of Medicine
Websites
Education
- University of California, Santa Cruz, PhD
- University of Southern California, BS
Publications
- Published on 9/1/2023
Millimaci AM, Trilles RV, McNeely JH, Brown LE, Beeler AB, Porco JA. Synthesis of Neocannabinoids Using Controlled Friedel-Crafts Reactions. J Org Chem. 2023 Sep 15; 88(18):13135-13141. PMID: 37657122.
Read at: PubMed - Published on 3/7/2023
Naineni SK, Cencic R, Robert F, Brown LE, Haque M, Scott-Talib J, Sénéchal P, Schmeing TM, Porco JA, Pelletier J. Exploring the targeting spectrum of rocaglates among eIF4A homologs. RNA. 2023 Jun; 29(6):826-835. PMID: 36882295.
Read at: PubMed - Published on 1/23/2023
Kavouris JA, McCall LI, Giardini MA, De Muylder G, Thomas D, Garcia-Pérez A, Cantizani J, Cotillo I, Fiandor JM, McKerrow JH, De Oliveira CI, Siqueira-Neto JL, González S, Brown LE, Schaus SE. Discovery of pyrazolopyrrolidinones as potent, broad-spectrum inhibitors of Leishmania infection. Front Trop Dis. 2023; 3. PMID: 36818551.
Read at: PubMed - Published on 10/31/2022
Shaashua L, Ben-Shmuel A, Pevsner-Fischer M, Friedman G, Levi-Galibov O, Nandakumar S, Barki D, Nevo R, Brown LE, Zhang W, Stein Y, Lior C, Kim HS, Bojmar L, Jarnagin WR, Lecomte N, Mayer S, Stok R, Bishara H, Hamodi R, Levy-Lahad E, Golan T, Porco JA, Iacobuzio-Donahue CA, Schultz N, Tuveson DA, Lyden D, Kelsen D, Scherz-Shouval R. BRCA mutational status shapes the stromal microenvironment of pancreatic cancer linking clusterin expression in cancer associated fibroblasts with HSF1 signaling. Nat Commun. 2022 Oct 31; 13(1):6513. PMID: 36316305.
Read at: PubMed - Published on 10/12/2022
Brown LE, Seitz S, Kondas AV, Marcyk PT, Filone CM, Hossain MM, Schaus SE, Olson VA, Connor JH. Identification of Small Molecules with Improved Potency against Orthopoxviruses from Vaccinia to Smallpox. Antimicrob Agents Chemother. 2022 Nov 15; 66(11):e0084122. PMID: 36222522.
Read at: PubMed - Published on 9/6/2022
Lehman SL, Wechsler T, Schwartz K, Brown LE, Porco JA, Devine WG, Pelletier J, Shankavaram UT, Camphausen K, Tofilon PJ. Inhibition of the Translation Initiation Factor eIF4A Enhances Tumor Cell Radiosensitivity. Mol Cancer Ther. 2022 Sep 06; 21(9):1406-1414. PMID: 35732578.
Read at: PubMed - Published on 6/18/2022
Praditya DF, Klöhn M, Brüggemann Y, Brown LE, Porco JA, Zhang W, Kinast V, Kirschning A, Vondran FWR, Todt D, Steinmann E. Identification of structurally re-engineered rocaglates as inhibitors against hepatitis E virus replication. Antiviral Res. 2022 Aug; 204:105359. PMID: 35728703.
Read at: PubMed - Published on 11/3/2021
Xu W, Brown LE, Porco JA. Divergent, C-C Bond Forming Macrocyclizations Using Modular Sulfonylhydrazone and Derived Substrates. J Org Chem. 2021 12 03; 86(23):16485-16510. PMID: 34730970.
Read at: PubMed - Published on 7/10/2021
Chatterjee S, Yabaji SM, Rukhlenko OS, Bhattacharya B, Waligurski E, Vallavoju N, Ray S, Kholodenko BN, Brown LE, Beeler AB, Ivanov AR, Kobzik L, Porco JA, Kramnik I. Channeling macrophage polarization by rocaglates increases macrophage resistance to Mycobacterium tuberculosis. iScience. 2021 Aug 20; 24(8):102845. PMID: 34381970.
Read at: PubMed - Published on 3/4/2021
Viarengo-Baker LA, Brown LE, Rzepiela AA, Whitty A. Defining and navigating macrocycle chemical space. Chem Sci. 2021 Mar 04; 12(12):4309-4328. PMID: 34163695.
Read at: PubMed
View 33 more publications: View full profile at BUMC