Lauren E Brown
Research Associate Professor, Chemistry
Other Positions
- Research Assistant Professor, Pharmacology, Physiology & Biophysics, Boston University Chobanian & Avedisian School of Medicine
Websites
Education
- University of California, Santa Cruz, PhD
- University of Southern California, BS
Publications
- Published on 8/6/2024
Keiser PT, Zhang W, Ricca M, Wacquiez A, Grimins A, Cencic R, Patten JJ, Shah P, Padilha E, Connor JH, Pelletier J, Lyons SM, Saeed M, Brown LE, Porco JA, Davey RA. Amidino-Rocaglates (ADRs), a class of synthetic rocaglates, are potent inhibitors of SARS-CoV-2 replication through inhibition of viral protein synthesis. Antiviral Res. 2024 Aug 06; 105976. PMID: 39117283.
Read at: PubMed - Published on 5/3/2024
Thirman HL, Hayes MJ, Brown LE, Porco JA, Irish JM. Single Cell Profiling Distinguishes Leukemia-Selective Chemotypes. bioRxiv. 2024 May 03. PMID: 38826485.
Read at: PubMed - Published on 4/23/2024
Volegova MP, Brown LE, Banerjee U, Dries R, Sharma B, Kennedy A, Porco JA, George RE. The MYCN 5' UTR as a therapeutic target in neuroblastoma. Cell Rep. 2024 May 28; 43(5):114134. PMID: 38662542.
Read at: PubMed - Published on 4/19/2024
Goldstein SI, Fan AC, Wang Z, Naineni SK, Lengqvist J, Chernobrovkin A, Garcia-Gutierrez SB, Cencic R, Patel K, Huang S, Brown LE, Emili A, Porco JA. Proteomic Discovery of RNA-Protein Molecular Clamps Using a Thermal Shift Assay with ATP and RNA (TSAR). bioRxiv. 2024 Apr 19. PMID: 38659867.
Read at: PubMed - Published on 2/20/2024
Fallah S, Duncan D, Reichl KD, Smith MJ, Wang W, Porco JA, Brown LE, Whitesell L, Robbins N, Cowen LE. A chemical screen identifies structurally diverse metal chelators with activity against the fungal pathogen Candida albicans. Microbiol Spectr. 2024 Apr 02; 12(4):e0409523. PMID: 38376363.
Read at: PubMed - Published on 9/1/2023
Millimaci AM, Trilles RV, McNeely JH, Brown LE, Beeler AB, Porco JA. Synthesis of Neocannabinoids Using Controlled Friedel-Crafts Reactions. J Org Chem. 2023 Sep 15; 88(18):13135-13141. PMID: 37657122.
Read at: PubMed - Published on 3/7/2023
Naineni SK, Cencic R, Robert F, Brown LE, Haque M, Scott-Talib J, Sénéchal P, Schmeing TM, Porco JA, Pelletier J. Exploring the targeting spectrum of rocaglates among eIF4A homologs. RNA. 2023 Jun; 29(6):826-835. PMID: 36882295.
Read at: PubMed - Published on 1/23/2023
Kavouris JA, McCall LI, Giardini MA, De Muylder G, Thomas D, Garcia-Pérez A, Cantizani J, Cotillo I, Fiandor JM, McKerrow JH, De Oliveira CI, Siqueira-Neto JL, González S, Brown LE, Schaus SE. Discovery of pyrazolopyrrolidinones as potent, broad-spectrum inhibitors of Leishmania infection. Front Trop Dis. 2023; 3. PMID: 36818551.
Read at: PubMed - Published on 10/31/2022
Shaashua L, Ben-Shmuel A, Pevsner-Fischer M, Friedman G, Levi-Galibov O, Nandakumar S, Barki D, Nevo R, Brown LE, Zhang W, Stein Y, Lior C, Kim HS, Bojmar L, Jarnagin WR, Lecomte N, Mayer S, Stok R, Bishara H, Hamodi R, Levy-Lahad E, Golan T, Porco JA, Iacobuzio-Donahue CA, Schultz N, Tuveson DA, Lyden D, Kelsen D, Scherz-Shouval R. BRCA mutational status shapes the stromal microenvironment of pancreatic cancer linking clusterin expression in cancer associated fibroblasts with HSF1 signaling. Nat Commun. 2022 Oct 31; 13(1):6513. PMID: 36316305.
Read at: PubMed - Published on 10/12/2022
Brown LE, Seitz S, Kondas AV, Marcyk PT, Filone CM, Hossain MM, Schaus SE, Olson VA, Connor JH. Identification of Small Molecules with Improved Potency against Orthopoxviruses from Vaccinia to Smallpox. Antimicrob Agents Chemother. 2022 Nov 15; 66(11):e0084122. PMID: 36222522.
Read at: PubMed
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