Joseph Kaserman, MD
Assistant Professor, Medicine
Biography
Dr. Kaserman is an Assistant Professor of Medicine at the Chobanian and Avedisian School of Medicine and a member of the Pulmonary, Allergy, Sleep and Critical Care Medicine section as well as a researcher in the Wilson Lab at the Center for Regenerative Medicine of Boston University and Boston Medical Center. His research has focused on studying the biological underpinnings of the genetic disease alpha-1 antitrypsin deficiency using pluripotent stem cell models combined with gene editing technology in order to rationally develop potential future disease modifying and curative therapies.
Other Positions
- Member, Pulmonary Center, Boston University
- Member, Center for Regenerative Medicine, Boston University
Education
- University of Vermont College of Medicine, MD
- Cornell University, BS
Publications
- Published on 10/29/2024
Soares De Oliveira L, Kaserman JE, Van Der Spek AH, Lee NJ, Undeutsch HJ, Werder RB, Wilson AA, Hollenberg AN. Thyroid hormone receptor beta (THRß1) is the major regulator of T3 action in human iPSC-derived hepatocytes. Mol Metab. 2024 Dec; 90:102057. PMID: 39481850.
Read at: PubMed - Published on 10/1/2024
Hu Y, Soares De Oliveira L, Falize K, Paul van Trotsenburg AS, Fliers E, Kaserman JE, Wilson AA, Hollenberg AN, Bruinstroop E, Boelen A. Disturbed function of TBL1X has a differential effect on T3-regulated gene expression in two human liver cell models. Eur Thyroid J. 2024 Oct 01; 13(5). PMID: 39316725.
Read at: PubMed - Published on 12/6/2022
Kaserman JE, Werder RB, Wang F, Matte T, Higgins MI, Dodge M, Lindstrom-Vautrin J, Bawa P, Hinds A, Bullitt E, Caballero IS, Shi X, Gerszten RE, Brunetti-Pierri N, Liesa M, Villacorta-Martin C, Hollenberg AN, Kotton DN, Wilson AA. Human iPSC-hepatocyte modeling of alpha-1 antitrypsin heterozygosity reveals metabolic dysregulation and cellular heterogeneity. Cell Rep. 2022 Dec 06; 41(10):111775. PMID: 36476855.
Read at: PubMed - Published on 9/8/2022
Scoon WA, Mancio-Silva L, Suder EL, Villacorta-Martin C, Lindstrom-Vautrin J, Bernbaum JG, Mazur S, Johnson RF, Olejnik J, Flores EY, Mithal A, Wang F, Hume AJ, Kaserman JE, March-Riera S, Wilson AA, Bhatia SN, Mühlberger E, Mostoslavsky G. Ebola virus infection induces a delayed type I IFN response in bystander cells and the shutdown of key liver genes in human iPSC-derived hepatocytes. Stem Cell Reports. 2022 Oct 11; 17(10):2286-2302. PMID: 36084636.
Read at: PubMed - Published on 6/24/2022
Hume AJ, Heiden B, Olejnik J, Suder EL, Ross S, Scoon WA, Bullitt E, Ericsson M, White MR, Turcinovic J, Thao TTN, Hekman RM, Kaserman JE, Huang J, Alysandratos KD, Toth GE, Jakab F, Kotton DN, Wilson AA, Emili A, Thiel V, Connor JH, Kemenesi G, Cifuentes D, Mühlberger E. Correction: Recombinant Lloviu virus as a tool to study viral replication and host responses. PLoS Pathog. 2022 Jun; 18(6):e1010659. PMID: 35749346.
Read at: PubMed - Published on 2/4/2022
Hume AJ, Heiden B, Olejnik J, Suder EL, Ross S, Scoon WA, Bullitt E, Ericsson M, White MR, Turcinovic J, Thao TTN, Hekman RM, Kaserman JE, Huang J, Alysandratos KD, Toth GE, Jakab F, Kotton DN, Wilson AA, Emili A, Thiel V, Connor JH, Kemenesi G, Cifuentes D, Mühlberger E. Recombinant Lloviu virus as a tool to study viral replication and host responses. PLoS Pathog. 2022 02; 18(2):e1010268. PMID: 35120176.
Read at: PubMed - Published on 7/2/2021
Werder RB, Kaserman JE, Packer MS, Lindstrom-Vautrin J, Villacorta-Martin C, Young LE, Aratyn-Schaus Y, Gregoire F, Wilson AA. Adenine base editing reduces misfolded protein accumulation and toxicity in alpha-1 antitrypsin deficient patient iPSC-hepatocytes. Mol Ther. 2021 11 03; 29(11):3219-3229. PMID: 34217893.
Read at: PubMed - Published on 7/2/2020
Kaserman JE, Hurley K, Dodge M, Villacorta-Martin C, Vedaie M, Jean JC, Liberti DC, James MF, Higgins MI, Lee NJ, Washko GR, San Jose Estepar R, Teckman J, Kotton DN, Wilson AA. A Highly Phenotyped Open Access Repository of Alpha-1 Antitrypsin Deficiency Pluripotent Stem Cells. Stem Cell Reports. 2020 07 14; 15(1):242-255. PMID: 32619491.
Read at: PubMed - Published on 9/15/2018
Kaserman JE, Wilson AA. Patient-Derived Induced Pluripotent Stem Cells for Alpha-1 Antitrypsin Deficiency Disease Modeling and Therapeutic Discovery. Chronic Obstr Pulm Dis. 2018 Sep 15; 5(4):258-266. PMID: 30723783.
Read at: PubMed - Published on 6/5/2018
Segeritz CP, Rashid ST, de Brito MC, Serra MP, Ordonez A, Morell CM, Kaserman JE, Madrigal P, Hannan NRF, Gatto L, Tan L, Wilson AA, Lilley K, Marciniak SJ, Gooptu B, Lomas DA, Vallier L. hiPSC hepatocyte model demonstrates the role of unfolded protein response and inflammatory networks in a1-antitrypsin deficiency. J Hepatol. 2018 Oct; 69(4):851-860. PMID: 29879455.
Read at: PubMed
View 2 more publications: View full profile at BUMC