Jimmy W. Crott

Associate Professor, Boston University Chobanian & Avedisian School of Medicine

Biography

Jimmy Crott, PhD, Pathology & Laboratory Medicine, studies the interaction between diet, gut microbiome, colon tumorigenesis and aging. His ongoing projects involve identifying the active component of a chemoprotective bacterium, understanding the role of gut barrier integrity and tight junction proteins in aging and understanding the role of the gut microbiome in colon cancer prevention by a Mediterranean diet. He came to BU/BMC in February 2022 from Tufts University, where he served in a variety of roles over 20 years, most recently as the leader of the Microbiome and Aging Program at the Jean Mayer USDA Human Nutrition Research Center on Aging and strategic initiative advisor in the Office of the Vice Provost of Research.

Publications

  • Published 6/22/2026

    Shnayder S, Do V, Wang J, Machado L, Rosa S, Kusaku L, Kuo B, Hutchinson J, Ogden G, Majeti N, Guo W, Beck S, McVey M, Crott JW. Lifelong Consumption of Freeze-Dried Parabacteroides Distasonis Improves Gut Barrier Integrity and Extends Lifespan and Health Span in Drosophila Melanogaster. Aging Dis. 2026 Jun 22. PMID: 42372240.

    Read at: PubMed

  • Published 3/28/2026

    Guo W, Carretero Santos L, Yee Koh G, Malamy M, Hawley A, Beachy H, Whelpley B, Wang J, Dempsey DR, Crott JW. Identification and characterization of a lipopolysaccharide binding, anti-inflammatory protein from Parabacteroides distasonis. Gut Microbes. 2026 Dec 31; 18(1):2650007. PMID: 41904604.

    Read at: PubMed

  • Published 2/21/2025

    Gülsan EE, Nowshad F, Leigh MD, Crott JW, Park H, Martin G, Safe S, Chapkin RS, Jayaraman A, Lee K. A Chalcone Synthase-like Bacterial Protein Catalyzes Heterocyclic C-Ring Cleavage of Naringenin to Alter Bioactivity Against Nuclear Receptors in Colonic Epithelial Cells. Metabolites. 2025 Feb 21; 15(3). PMID: 40137111.

    Read at: PubMed

  • Published 2/6/2025

    Guo W, Crossland N, Crott JW. Mediterranean diet improves liver health but does not protect against azoxymethane-induced colon tumorigenesis compared to Western diet in A/J mice. Exp Mol Pathol. 2025 Mar; 141:104953. PMID: 39919552.

    Read at: PubMed

  • Published 12/15/2024

    Smith KM, Francisco SG, Zhu Y, LeRoith T, Davis ML, Crott JW, Barger K, Greenberg AS, Smith DE, Taylor A, Yeruva L, Rowan S. Dietary prevention of antibiotic-induced dysbiosis and mortality upon aging in mice. FASEB J. 2024 Dec 15; 38(23):e70241. PMID: 39655692.

    Read at: PubMed

View All 59 Publications:   View Full Profile in BUMC

Websites

Education

  • University of Adelaide, PhD
  • University of Adelaide, BSc
  • University of Adelaide, BSc

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